Depletion study of three formulations of flumequine in edible tissues and drug transfer into chicken feathers

Cornejo, Javiera; Lapierre, Lisette; Iragüen, D.; Pizarro, Nieves; Hidalgo, Héctor; Martín, Betty San

doi:10.1111/j.1365-2885.2010.01208.x

Cited by 32 publications

(22 citation statements)

References 31 publications

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“…There is a need for methods that are able to detect the use of antibiotics administered over the entire life span of an animal, including treatments administered during the first days of the animals’ lives. In previous research focusing on the excretion of oxytetracycline [ 7 ], multiple fluoroquinolones (enrofloxacin, its metabolite ciprofloxacin [ 8 ], and flumequin [ 9 ]) and florfenicol and its metabolite florfenicol amine [ 10 ] to feathers, it has already been shown that antibiotic residues can still be detected in feathers long after treatment. In another study, different antibiotics in feather meal, originating from different countries, were detected, including antibiotics that are registered as banned substances in the country of origin [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

The analysis of tetracyclines, quinolones, macrolides, lincosamides, pleuromutilins, and sulfonamides in chicken feathers using UHPLC-MS/MS in order to monitor antibiotic use in the poultry sector

et al. 2017

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In The Netherlands, all antibiotic treatments should be registered at the farm and in a central database. To enforce correct antibiotic use and registration, and to enforce prudent use of antibiotics, there is a need for methods that are able to detect antibiotic treatments. Ideally, such a method is able to detect antibiotic applications during the entire lifespan of an animal, including treatments administered during the first days of the animals’ lives. Monitoring tissue, as is common practice, only provides a limited window of opportunity, as residue levels in tissue soon drop below measurable quantities. The analysis of feathers proves to be a promising tool in this respect. Furthermore, a qualitative confirmatory method was developed for the analyses of six major groups of antibiotics in ground chicken feathers, aiming for a detection limit as low as reasonably possible. The method was validated according to Commission Decision 2002/657/EC. All compounds comply with the criteria and, as a matter of fact, 58% of the compounds could also be quantified according to regulations. Additionally, we demonstrated that a less laborious method, in which whole feathers were analyzed, proved successful in the detection of applied antibiotics. Most compounds could be detected at levels of 2 μg kg−1 or below with the exception of sulfachloropyridazine, tylosin, and tylvalosin. This demonstrates the effectiveness of feather analysis to detect antibiotic use to allow effective enforcement of antibiotic use and prevent the illegal, off-label, and nonregistered use of antibiotics.

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Section: Introductionmentioning

confidence: 99%

The analysis of tetracyclines, quinolones, macrolides, lincosamides, pleuromutilins, and sulfonamides in chicken feathers using UHPLC-MS/MS in order to monitor antibiotic use in the poultry sector

et al. 2017

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“…In 2012, Love et al, 29 designed a study to build up on previous findings reported in 2007 and 2011 by San Martin et al 9 and Cornejo et al, 10 respectively, regarding the presence of antimicrobials in chicken feathers. Love et al 29 decided to sample feather meals sourced from several states in the USA.…”

Section: Discussionmentioning

confidence: 99%

“…San Martin et al, 9 found that feathers had higher concentrations of enrofloxacin and its metabolite ciprofloxacin than muscle, liver and kidney tissues from birds that had been treated with enrofloxacin. Later on, Cornejo et al, 10 found higher antimicrobial concentration levels in feather matrix than in liver and muscle samples, after the calculated withdrawal period for their formulation had elapsed. Likewise, they found that flumequine was eliminated from feathers more slowly than from other tissues.…”

Section: Introductionmentioning

confidence: 99%

In-House Validation of HPLC-MS/MS Methods for Detection and Quantification of Tetracyclines in Edible Tissues and Feathers of Broiler Chickens

Pokrant

Maddaleno

Araya

et al. 2017

J. Braz. Chem. Soc.

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For the detection of tetraciclines in feathers, muscle and liver, an internal protocol was designed for in-house validation of two methods, through high performance liquid chromatography with tandem mass spectrometric (HPLC-MS/MS) techniques. This protocol was based on the recommendation of the decision 2002/657/EC from the European Community as well as the food and drug administration (FDA) VICHGL49. Limit of detection (LOD) was set at 20 μg kg -1 and the limit of quantification (LOQ) ranged from 21.5 to 24.2, 21.2 to 21.6, and 25.0 to 27.7 μg kg -1 in feahers, muscle and liver samples, respectively, for all analytes. The calibrations curves show a coefficient of determination (R 2 ) above 0.98, 0.99 and 0.96 for feathers, muscle and liver samples, respectively. Analyte recovery ranged from 92 to 108%. In conclusion, these methods can be deemed accurate and reliable, and their validation is a fundamental step to be performed in depletion studies on these matrices.

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“…Consequently, there was a need for matrices in which antibiotics could be detected over a longer time span. For the monitoring of antibiotic use in poultry, the analysis of feathers provided a means to detect antibiotic residues with a long detection window, even after they were excreted fully from muscle and liver (San Martín et al 2007;Cornejo et al 2011b;Berendsen et al 2013;Cornejo et al 2017;Pokrant et al 2018;Církva et al 2019;Maddaleno et al 2019). Using such a noninvasive method, antibiotic use during almost the whole lifespan of a broiler can be monitored, making it possible to better enforce registration of antibiotics use aiming for prudent application (Jansen et al 2016(Jansen et al , 2017.…”

Section: Introductionmentioning

confidence: 99%

The vertical transmission of antibiotic residues from parent hens to broilers

Jansen

Berentsen

Arends

et al. 2020

Food Additives & Contaminants: Part A

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Imprudent and superfluous use of antibiotics contributes to the selection of resistant bacteria, which is a large threat to human health. Therefore analytical procedures have been implemented in the poultry production sector to check if antibiotic treatments are registered, aiming to achieve more prudent use of antibiotics. These methods rely on the analysis of feathers, a matrix in which antibiotic residues persist. However, other routes besides direct administration, through which poultry feathers could contain antibiotic residues, should also be taken into account. In this research the vertical transmission from parent hen to broiler was investigated through a controlled animal study for the antibiotics enrofloxacin, doxycycline and sulfachlorpyridazine. Vertical transmission was observed for all antibiotics to both egg and egg shell. Also it is demonstrated that the transferred antibiotics from parent hen to chick are subsequently excreted via the chick's droppings. Through this route, the broilers' environment is contaminated. If eggs are hatched that were taken during treatment of the parent hen, this indirect route and/or the direct vertical transmission can eventually result in the detection of low concentrations of antibiotic residues in the broilers' feathers at greater age: <50 µg kg −1 for freely extractable residues and <10 µg kg −1 for non-freely extractable residues. No antibiotics were detected in the broilers' muscle or kidney from 4 weeks of age. This research provides relevant information regarding the possible amount of residues originating from vertical transmission when monitoring matrices such as feathers and broiler droppings in order to stimulate correct use and registration of antibiotics in the poultry sector.

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Depletion study of three formulations of flumequine in edible tissues and drug transfer into chicken feathers

Cited by 32 publications

References 31 publications

The analysis of tetracyclines, quinolones, macrolides, lincosamides, pleuromutilins, and sulfonamides in chicken feathers using UHPLC-MS/MS in order to monitor antibiotic use in the poultry sector

The analysis of tetracyclines, quinolones, macrolides, lincosamides, pleuromutilins, and sulfonamides in chicken feathers using UHPLC-MS/MS in order to monitor antibiotic use in the poultry sector

In-House Validation of HPLC-MS/MS Methods for Detection and Quantification of Tetracyclines in Edible Tissues and Feathers of Broiler Chickens

The vertical transmission of antibiotic residues from parent hens to broilers

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