Most European cities are characterized by very large areas, often formed by buildings of low quality, from a series of perspectives (architectural, technological, materials, technical systems, etc.). The possibility of renovating them is strategic to improve both the quality of life and to the possibility of economic recovery for building companies. In the last decades, the attention of the scientific community has been addressed to the energy renovation, thanks to the strong activities of the European Community in this field. However, since a relevant part of the EC territory is at risk of earthquake, the possibility to combine both energy and seismic renovation actions may be strategic for many countries. In particular, Italy and Romania are linked by a common social tradition that springs from the Roman Empire. Nowadays, this link is stronger, thanks to common interests in social, cultural and business fields. Therefore, the investigation of possible synergies for seismic and energy renovation strategies may be really interesting for both countries. In this paper, after an overview of regulations and common practices for buildings with reinforced concrete structures, in both states, some key combined renovation interventions will be described and discussed, as well as advantages and perspectives of integrated renovation approaches. The outcomes of this work are to show the way to transform existing energy-consuming and seismic-prone buildings into energy-efficient and seismic-resistant ones.