Depolarization of the Atrial Subepicardium in Rats with Experimentally Induced Pulmonary Hypertension

Smirnova, Svetlana; Roshchevskaya, I. M.

doi:10.1007/s10517-021-05145-z

Cited by 2 publications

(8 citation statements)

References 11 publications

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“…Contudo, no tecido afetado dos animais com HP-MCT, ocorre a geração quase simultânea de duas ondas de despolarização: uma próxima à entrada da veia cava e outra na área das junções das veias pulmonares no AE. 12 …”

Section: Discussionunclassified

“… 11 Vários estudos sugerem que a assinatura estrutural, molecular e funcional do átrio direito (AD) e do AE pode ser diferente na HP. 5 , 12 - 14 …”

Section: Introductionunclassified

“… 11 Several studies suggest that the structural, molecular and functional signature of the right atrium (RA) and LA may be different in PH. 5 , 12 - 14 …”

Section: Introductionmentioning

confidence: 99%

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Estudo Morfofuncional do Átrio Esquerdo Isolado de um Modelo Experimental de Hipertensão Pulmonar em Ratos

Teixeira-Fonseca,

Joviano-Santos,

Machado

et al. 2023

Arquivos Brasileiros De Cardiologia

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Section: Discussionunclassified

“… 11 Vários estudos sugerem que a assinatura estrutural, molecular e funcional do átrio direito (AD) e do AE pode ser diferente na HP. 5 , 12 - 14 …”

Section: Introductionunclassified

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Estudo Morfofuncional do Átrio Esquerdo Isolado de um Modelo Experimental de Hipertensão Pulmonar em Ratos

Teixeira-Fonseca,

Joviano-Santos,

Machado

et al. 2023

Arquivos Brasileiros De Cardiologia

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“…To investigate the effects of PAH-induced remodelling on atrial electrical activity, we identified relative changes in atrial remodelling from experimental data in MCT-induced PAH rats [18,[25][26][27][28], dogs [20,29], rabbits [11] and humans [7][8][9][30][31][32][33][34][35][36][37][38][39]. These experimental data encompass changes in the expression of ion channel-related genes, Ca 2+ -handling-related genes, connexin genes, fibrosis-related genes and inflammasome-related genes [9,[12][13][14][15]18,19,40] (figure 1a).…”

Section: Methodsmentioning

confidence: 99%

“…Prolonged APD/ERP has been consistently observed in the RA of animals and humans [7][8][9]18,[25][26][27][28][30][31][32][33][34][35][36][37][38][39]. The prolonged APD can be attributed to PAH-induced remodelling of atrial potassium (K + ) currents, including reductions in Kcnj2, Kcna5 and Kcnq1.…”

Section: Mechanism Of Pah-induced Af Due To Ap Prolongation In the Ramentioning

confidence: 99%

Mechanisms of pulmonary arterial hypertension-induced atrial fibrillation: insights from multi-scale models of the human atria

Bai,

Lo,

Kennelly

et al. 2023

Interface Focus.

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This study aimed to use multi-scale atrial models to investigate pulmonary arterial hypertension (PAH)-induced atrial fibrillation mechanisms. The results of our computer simulations revealed that, at the single-cell level, PAH-induced remodelling led to a prolonged action potential (AP) (ΔAPD: 49.6 ms in the right atria (RA) versus 41.6 ms in the left atria (LA)) and an increased calcium transient (CaT) (ΔCaT: 7.5 × 10 −2 µM in the RA versus 0.9 × 10 −3 µM in the LA). Moreover, heterogeneous remodelling increased susceptibility to afterdepolarizations, particularly in the RA. At the tissue level, we observed a significant reduction in conduction velocity (CV) (ΔCV: −0.5 m s –1 in the RA versus −0.05 m s –1 in the LA), leading to a shortened wavelength in the RA, but not in the LA. Additionally, afterdepolarizations in the RA contributed to enhanced repolarization dispersion and facilitated unidirectional conduction block. Furthermore, the increased fibrosis in the RA amplified the likelihood of excitation wave breakdown and the occurrence of sustained re-entries. Our results indicated that the RA is characterized by increased susceptibility to afterdepolarizations, slow conduction, reduced wavelength and upregulated fibrosis. These findings shed light on the underlying factors that may promote atrial fibrillation in patients with PAH.

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Depolarization of the Atrial Subepicardium in Rats with Experimentally Induced Pulmonary Hypertension

Cited by 2 publications

References 11 publications

Estudo Morfofuncional do Átrio Esquerdo Isolado de um Modelo Experimental de Hipertensão Pulmonar em Ratos

Estudo Morfofuncional do Átrio Esquerdo Isolado de um Modelo Experimental de Hipertensão Pulmonar em Ratos

Mechanisms of pulmonary arterial hypertension-induced atrial fibrillation: insights from multi-scale models of the human atria

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