Deposit of glass fragments during femtosecond laser penetrating keratoplasty

Nuzzo, Valeria; Plamann, Karsten; Savoldelli, Michéle; Aptel, Florent; Reynier, Bertrand; Pailloux, F.; Cabioc’h, Thierry; Albert, O.; Legeais, Jean‐Marc

doi:10.1007/s00417-008-0948-7

Cited by 5 publications

(2 citation statements)

References 26 publications

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“…The observation of periodical structures was recurrent in a series of five corneas analysed in this respect. The period, measured from TEM photographs, ranges between about 0.3 and 0.5 μm: the structures have features with subwavelength dimensions, however no clear dependency on focusing NA, wavelength or pulse energy could be established [180][181][182].…”

Section: Nonlinear Side Effectsmentioning

confidence: 99%

Ultrashort pulse laser surgery of the cornea and the sclera

Plamann¹,

Aptel²,

Arnold³

et al. 2010

J. Opt.

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The strongly localized interaction process of ultrashort laser pulses with tissue makes femtosecond lasers a powerful tool for eye surgery. These lasers are now routinely used in refractive surgery and other forms of surgery of the anterior segment of the eye. Several clinical laser systems also offer options for corneal grafting and the potential use of ultrashort pulse lasers in glaucoma surgery has been the object of several recent studies which have shown promising results. While devices aimed for interventions in clear tissue may be based on available solid state or fibre laser technology, the development of tools for surgery in more strongly scattering tissue has to account for the compromised tissular transparency and requires the development of optimized laser sources. The present paper focuses on surgery of clear and pathological cornea as well as sclera. It aims to give an overview over typical medical indications for ultrashort pulse laser surgery, the optics of the tissues involved, the available laser technology, the laser–tissue interaction process, and possible future developments.

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Section: Nonlinear Side Effectsmentioning

confidence: 99%

Ultrashort pulse laser surgery of the cornea and the sclera

Plamann¹,

Aptel²,

Arnold³

et al. 2010

J. Opt.

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“…32 The shape and the precise size of the disrupted tissue is mainly studied on histological sections by optical and electron transmission microscopy. 33,34 It has been proven that OCT imaging can perform interesting information for glaucoma surgery 35 or for corneal surgery 36 but with a few micrometers resolution. The use of an imaging technique, that provides a 1 ϫ 1.5-m resolution, to improve the laser surgery and to achieve a better cut of the cornea for corneal graft is of great interest for the surgeon, providing information on the interface quality and also imaging tiny changes of the tissue structure and the presence of small cavitation bubbles.…”

Section: Introductionmentioning

confidence: 99%

Human graft cornea and laser incisions imaging with micrometer scale resolution full-field optical coherence tomography

et al. 2010

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Micrometer scale resolution full-field optical coherence tomography (FF-OCT) is developed for imaging human graft corneas. Three-dimensional (3-D) images with ultrahigh resolution (respectively, 1 and 1.5 μm in the axial and transverse directions), comparable to traditional histological sections, are obtained allowing the visualization of the cells and the precise structure of the different layers that compose the tissue. The sensitivity of our device enables imaging the entire thickness of the cornea, even in edematous corneas more than 800 μm thick. Furthermore, we provide tomographic 3-D images of laser incisions inside the tissue at various depths without slicing the studied corneas. The effects of laser ablations can be observed, along various optical sections, directly in the bulk of the sample with high accuracy, providing information on the interface quality and also imaging tiny changes of the tissue structure. FF-OCT appears to be a powerful tool for subcellular imaging of the corneal structure and pathologies on the entire thickness of the tissue as well as interface quality and changes in the collagen structure due to laser incisions on ex vivo human cornea.

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