Deposition and depletion of the coccidiostats toltrazuril and halofuginone in eggs

Mulder, Patrick P.J.; Balzer-Rutgers, P.; Brinke, E.M. te; Bolck, Y.J.C.; Berendsen, B.J.A.; Gerçek, H.; Schat, B.; Rhijn, J.A. van

doi:10.1016/j.aca.2004.08.017

Cited by 26 publications

(22 citation statements)

References 3 publications

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“…Data from both substances are derived from broiler chickens; no pharmacokinetic data of laying hens are available so no clear conclusions between pharmacokinetic data and transfer ratios to the egg can be made. The transfer of other coccidiostats from feed to eggs has also been investigated for ionophoric as well as for non-ionophoric coccidiostats (Mortier 2005;Mulder et al 2005;EFSA 2008aEFSA , 2008c. Mortier et al (2005) found narasin plateau concentrations of 6 and 90 mg kg À1 in whole eggs when laying hens received feed containing 2144 mg kg À1 and 40.9 mg kg À1 narasin.…”

Section: Discussionmentioning

confidence: 99%

Transfer of the coccidiostats monensin and lasalocid from feed at cross-contamination levels to whole egg, egg white and egg yolk

Vandenberge¹,

Delezie²,

Huyghebaert³

et al. 2012

Food Additives & Contaminants: Part A

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Recent legislation has addressed the unavoidable carry-over of coccidiostats and histomonostats in feed, which may lead to the presence of residues of these compounds in eggs. In this study, laying hens received cross-contaminated feed at a ratio of 2.5%, 5% and 10% of the therapeutic dose of monensin and lasalocid for broilers. The eggs were collected during the treatment and depletion period and were analysed using liquid chromatography-tandem mass spectrometry. The different egg matrices were separated and analysed during the plateau phase. High lasalocid concentrations, which exceeded the maximum residue level, and low monensin concentrations were found in whole egg. Plateau levels were reached at days 7-9 for lasalocid and at days 3-5 for monensin. For lasalocid, the highest concentrations were measured in egg yolk; residue concentrations in egg white were very low.

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Section: Discussionmentioning

confidence: 99%

Transfer of the coccidiostats monensin and lasalocid from feed at cross-contamination levels to whole egg, egg white and egg yolk

Vandenberge¹,

Delezie²,

Huyghebaert³

et al. 2012

Food Additives & Contaminants: Part A

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“…The validation method was carried out according to the Revision of Commission Decision93/256/EC [32]; therefore, instrumental linearity, specificity, recovery, precision, CCα and CCβ and robustness were studied.…”

Section: Validation Studymentioning

confidence: 99%

“…At the moment, there are few papers about toltrazuril and its metabolites in eggs or in feedstuffs [30][31][32] and, to our knowledge, there are no scientific works about these five synthetic coccidiostats and the toltrazuril metabolites all together.…”

Section: Introductionmentioning

confidence: 99%

Liquid Chromatography Tandem Mass Spectrometry Analysis of Synthetic Coccidiostats in Eggs

et al. 2017

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Abstract:Coccidiostats are synthetic drugs administered to animals, especially to poultry, to cure coccidiosis. In this paper, we present a selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to analyze residues of five synthetic coccidiostats in eggs: clazuril, diclazuril, robenidine, nicarbazin, toltrazuril and its two metabolites. The extraction efficiency was evaluated by testing several solvents, pH, different volumes and time of extraction. The clean-up procedures were optimized using different solid phase extraction cartridges and different eluants. The chromatographic separation was achieved in reversed phase using a gradient of 0.1% formic acid in water and acetonitrile, whereas the MS detection was performed in negative electrospray ionization (ESI) for all the analytes, except for the robenidine. The developed method has been validated according to Commission Decision 2002/657/CE. The validation parameters, as linearity, precision, recovery, specificity, decision limit (CCα), detection capability (CCβ), and robustness have been determined. The proposed method resulted simple, fast, and suitable for screening and confirmation purposes.

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“…As a result, few multi-residue methods have been reported in literature for these residues. Some groups have successfully developed methods to measure toltrazuril residues in eggs [370,371]. Hormazabal and Yndestad developed a complex LLP method for isolating anticoccidial residues including amprolium from tissue, plasma and egg [7].…”

Section: Anticoccidialsmentioning

confidence: 99%

Current trends in sample preparation for growth promoter and veterinary drug residue analysis

Kinsella

O’Mahony

Malone

et al. 2009

Journal of Chromatography A

181

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A comprehensive review is presented on the current trends in sample preparation for isolation of veterinary drugs and growth promotors from foods. The objective of the review is to firstly give an overview of the sample preparation techniques that are applied in field. The review will focus on new techniques and technologies, which improve efficiency and coverage of residues. The underlying theme to the paper is the developments that have been made in multi-residue methods and particularly multi-class methods for residues of licensed animal health products, which have been developed in the last couple of years. The role of multi-class methods is discussed and how they can be accommodated in future residue surveillance.

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Deposition and depletion of the coccidiostats toltrazuril and halofuginone in eggs

Cited by 26 publications

References 3 publications

Transfer of the coccidiostats monensin and lasalocid from feed at cross-contamination levels to whole egg, egg white and egg yolk

Transfer of the coccidiostats monensin and lasalocid from feed at cross-contamination levels to whole egg, egg white and egg yolk

Liquid Chromatography Tandem Mass Spectrometry Analysis of Synthetic Coccidiostats in Eggs

Current trends in sample preparation for growth promoter and veterinary drug residue analysis

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