Deposition of functionalized calcium phosphate nanoparticles on functionalized polymer surfaces

Abstract

Calcium phosphate nanoparticles were functionalized using two polymeric additives: polyallylamine hydrochloride, PAH, giving them a positive charge, and polyacrylic acid, PAA, giving them a negative charge. These particles were deposited on surface-functionalized polymers (polyethylene terephthalate track-etch membranes; PET) by dip-coating. If the charge of the nanoparticles and the charge of the polymer membrane had an opposite sign, efficient adsorption was observed, whereas on unfunctionalized polymer surfaces, no adsorption occurred.Keywords: Nanoparticles; membranes; polymers; surface modification Calciumphosphat-Nanopartikel wurden mit zwei Polymeren funktionalisiert: Poly(allylamin hydrochlorid), PAH (führte zu positiv geladenen Partikeln), und Poly(acrylsäure), PAA (führte zu negativ geladenen Partikeln). Die Abscheidung auf auf oberflächen-funktionalisierten Polymeren (Polyethylenterephthalat-Kernspurmembranen; PET) erfolgte durch Dip-Coating. Eine effektive Adsorption wurde nur beobachtet, wenn Nanopartikel und Polymeroberfläche entgegengesetzte Ladungen aufwiesen. Auf unfunktionalisierten Polymeroberflächen erfolgte keine Adsorption.

Calcium phosphate nanoparticles as efficient carriers for photodynamic therapy against cells and bacteria

“…Due to their similarity to the mineral in human bone and teeth [21], they are generally non-toxic [22]. We have shown earlier how they can be functionalized with nucleic acids [23,24], polymers [25,26], and functionalized porphyrins [27]. We have now extended these studies to photosensitizers which can easily be included into the outer polymer layer around a particle.…”

“…The PSS functionalized and stabilized the emerging calcium phosphate nanoparticles [26]. The pH of the calcium and phosphate solutions was previously adjusted to 10 with ammonia solution.…”

Diffusion of aniline through a polyethylene terephthalate track-etched membrane

“…A high track to bulk etch rate ratio (>10 3 in the case of etching in 0.2 mol/L NaOH) allowed us to assume that the pores are practically cylindrical [23]. The carboxylic group density on the etched surface of such membranes is about 0.3 nm −2 [24]. Pore density (4 × 10 9 cm −2 ) was determined by scanning electron microscope.…”

Bone-targeted nanoplatform enables efficient modulation of bone tumor microenvironment for prostate cancer bone metastasis treatment

“…However, the CaP nanoparticle often precipitated rapidly due to its poor colloidal stability, which restricted its treatment effect (Huang et al., 2019 ). CaP can be functionalized by PEGylation, cationic polymers, natural polymers, cell-penetrating peptides, and biodegradable lipids, and these functionalizations would increase the stability of CaP nanoparticles (Urch et al., 2006 ; Chen et al., 2016 ; Chu et al., 2017 ; Khalifehzadeh & Arami, 2020 ). The lipid-coated CaP (LCP) is a non-viral gene delivery vehicle, which has been extensively studied by Huang (Li et al., 2012 ; Tang et al., 2018 ).…”