Deposition of PLA/CDHA composite coating via electrospraying

Zhou, Huan; Bhaduri, Sarit B.

doi:10.1080/09205063.2012.714726

Cited by 8 publications

(4 citation statements)

References 24 publications

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“…During electrospinning, the organic solvent, which could be toxic to cells, will be completely evaporated due to its high volatility [22]. Electrospraying has similar preparation process to electrospinning but is usually used with higher voltage and lower polymer density, which makes the polymer solution more easily broken up into droplets [23, 24]. The concept of electrospraying process was used to increase layer-to-layer adhesion, which could avoid drug-storing layer cracking and separating from backing layer during the stent expending.…”

Section: Resultsmentioning

confidence: 99%

Prototype of biliary drug-eluting stent with photodynamic and chemotherapy using electrospinning

et al. 2014

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BackgroundThe combination of biliary stent with photodynamic and chemotherapy seemed to be a beneficial palliative treatment of unresectable cholangiocarcinoma. However, by intravenous delivery to the target tumor the distribution of the drug had its limitations and caused serious side effect on non-target organs. Therefore, in this study, we are going to develop a localized eluting stent, named PDT-chemo stent, covered with gemcitabine (GEM) and hematoporphyrin (HP).MethodsThe prototype of PDT-chemo stent was made through electrospinning and electrospraying dual-processes with an electrical charge to cover the stent with a drug-storing membrane from polymer liquid. The design of prototype used PU as the material of the backing layer, and PCL/PEG blends in different molar ratio of 9:1 and of 1:4 were used in two drug-storing layers with GEM and HP loaded respectively.ResultsThe optical microscopy revealed that the backing layer was formed in fine fibers from electrospinning, while drug-storing layers, attributed to the droplets from electrospraying process. The covered membrane, the morphology of which was observed by scanning electron microscopy (SEM), covered the stent surface homogeneously without crack appearances. The GEM had almost 100% of electrosprayed efficiency than 70% HP loaded on the covered membrane due to the different solubility of drug in PEG/PCL blends. Drug release study confirmed the two-phased drug release pattern by regulating in different molar ratio of PEG/PCL blends polymer.ConclusionsThe result proves that the PDT-chemo stent is composed of a first burst-releasing phase from HP and a later slow-releasing phase from GEM eluting. This two-phase of drug eluting stent may provide a new prospect of localized and controlled release treatment for cholangiocarcinoma disease.

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Section: Resultsmentioning

confidence: 99%

Prototype of biliary drug-eluting stent with photodynamic and chemotherapy using electrospinning

et al. 2014

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“…Using the surface modification of physical deposition technique and wet chemical deposition technique to form the calcium phosphate (CaP) or HA coatings is a very attractive approach because BPs have a marked affinity to the substances [ 91 ]. Alternatively, the polymer coatings, including layer-by-layer (LBL), polymer brushes, dip coating, Langmuir–Blodgett, spin, and plasma-based coating methods, are also capable of loading BPs [ 92 , 93 ]. In this section, we focus on the mechanism of fabricating BP-coated implants ( Table 1 ) .…”

Section: Methods Of Fabricating Bp-coated Implantsmentioning

confidence: 99%

“…After 24 h, samples without PCL coating released >75% of ALN, and those with the PCL coating released approximately 50%. Moreover, composite coatings composed of CDHA, polylactic acid (PLA), and ALN were deposited on implants via electrospraying, which can control the slow release of ALN and promote osteogenesis [ 93 ]. Due to the prevention of the initial burst release of the PCL coating, the TCP-ALN-PCL composite coating scaffolds inhibited OC activity and promoted higher bone formation [ 228 ].…”

Section: Role Of Bps As Coatings To Promote Osseointegrationmentioning

confidence: 99%

Bisphosphonate-incorporated coatings for orthopedic implants functionalization

Zhang

Bai

et al. 2023

Materials Today Bio

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“…It is reported that ZnO particles deposited 'on' PLA fibers surface are more efficient against microbiological tests than that of type 'in' mats which were mainly seen in the fibers bulk. Zhou et al [201] found that PLA/CDHA coatings performed by electrospraying are PLA/CDHA coatings are favored by osteoblast cells and promoted bone formation while delivering the drugs locally. With PLA/HA as electrospun nanocomposites, Prabhakaran et al [170] have studied and demonstrated that ECM production, mineralization and subsequent tissue regeneration properties have improved to a larger extent.…”

Section: Electrospun Polymeric and Nanocomposite Particles For Ammentioning

confidence: 99%

Additive manufacturing technologies: an overview of challenges and perspective of using electrospraying

et al. 2018

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Additive manufacturing (AM) is integrated into almost each industry, with an objective to improve product functionality and decrease costs. Ever since from its introduction four decades ago, AM technologies have used numerous kinds of materials in polymers and composite materials to create complex 3D structures which were almost impossible to manufacture through conventional techniques. However, many concerns remain for widespread applications of 3D-printed materials, which include inhomogeneous distribution of particles, unavailability of spherical particles, poor surface finish, inadequate accuracy, shrinkage in the material, and mismatch in desired mechanical properties. To meet the high standards of part quality, immediate emphasize should be given to these pertaining issues and challenges needs to addressed from the grassroots level. It is understood that, electrospraying, a powder particle production technique, may hold great potential to address these challenges and needs of AM by synthesizing fine spherical particles of any material with high scalability and reproducibility. A comprehensive review has been done to discuss the necessity of electrospraying for AM by providing an extensive summary/insight in current material advances and also attempted to bring the connection between the electrospraying and commercialized AM methods. This article also encourages the readers in obtaining an understanding the leading-edge technology electrospraying and makes them to contribute toward the future generations more effectively.

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Deposition of PLA/CDHA composite coating via electrospraying

Cited by 8 publications

References 24 publications

Prototype of biliary drug-eluting stent with photodynamic and chemotherapy using electrospinning

Prototype of biliary drug-eluting stent with photodynamic and chemotherapy using electrospinning

Bisphosphonate-incorporated coatings for orthopedic implants functionalization

Additive manufacturing technologies: an overview of challenges and perspective of using electrospraying

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