Depot-Based Delivery Systems for Pro-Angiogenic Peptides: A Review

Hove, Amy H. Van; Benoit, Danielle S. W.

doi:10.3389/fbioe.2015.00102

Cited by 51 publications

(37 citation statements)

References 165 publications

(275 reference statements)

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“…However, critical limitations to this approach include unexpected side effects influenced by off-target sites and biomolecular treatment. Blood or interstitial flow, as the primary route for molecules to reach target sites, often guides their delivery into systemic circulation 11 . VEGF induces angiogenesis as well as inflammation, and over-induction of angiogenesis may lead to tumorous progression 12 .…”

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confidence: 99%

Microchannel network hydrogel induced ischemic blood perfusion connection

et al. 2020

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Angiogenesis induction into damaged sites has long been an unresolved issue. Local treatment with pro-angiogenic molecules has been the most common approach. However, this approach has critical side effects including inflammatory coupling, tumorous vascular activation, and off-target circulation. Here, the concept that a structure can guide desirable biological function is applied to physically engineer three-dimensional channel networks in implant sites, without any therapeutic treatment. Microchannel networks are generated in a gelatin hydrogel to overcome the diffusion limit of nutrients and oxygen three-dimensionally. Hydrogel implantation in mouse and porcine models of hindlimb ischemia rescues severely damaged tissues by the ingrowth of neighboring host vessels with microchannel perfusion. This effect is guided by microchannel size-specific regenerative macrophage polarization with the consequent functional recovery of endothelial cells. Multiple-site implantation reveals hypoxia and neighboring vessels as major causative factors of the beneficial function. This technique may contribute to the development of therapeutics for hypoxia/inflammatoryrelated diseases.

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confidence: 99%

Microchannel network hydrogel induced ischemic blood perfusion connection

et al. 2020

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“…As a result of these desired properties, hydrogels have been extensively studied as engineerable ECM mimics for tissue engineering and drug delivery applications [ 98 ]. Natural proteins or polysaccharides, such as collagen, alginate, chitosan, gelatin, or hyaluronic acid (HA), can be used to form hydrogels [ 99 ]. Natural hydrogels are better suited for drug delivery applications compared to nanovesicles, mainly because of their formulation stabilities and drug administration routes.…”

Section: Nanovesicles-hydrogels Interactionsmentioning

confidence: 99%

Engineering Smart Targeting Nanovesicles and Their Combination with Hydrogels for Controlled Drug Delivery

et al. 2020

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Smart engineered and naturally derived nanovesicles, capable of targeting specific tissues and cells and delivering bioactive molecules and drugs into them, are becoming important drug delivery systems. Liposomes stand out among different types of self-assembled nanovesicles, because of their amphiphilicity and non-toxic nature. By modifying their surfaces, liposomes can become stimulus-responsive, releasing their cargo on demand. Recently, the recognized role of exosomes in cell-cell communication and their ability to diffuse through tissues to find target cells have led to an increase in their usage as smart delivery systems. Moreover, engineering “smarter” delivery systems can be done by creating hybrid exosome-liposome nanocarriers via membrane fusion. These systems can be loaded in naturally derived hydrogels to achieve sustained and controlled drug delivery. Here, the focus is on evaluating the smart behavior of liposomes and exosomes, the fabrication of hybrid exosome-liposome nanovesicles, and the controlled delivery and routes of administration of a hydrogel matrix for drug delivery systems.

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“…Although promising results were shown in experimental animal studies for pro-angiogenic factors, such results were not attained in clinical studies 27,28. Despite the fact that the challenges associated with clinical translation are specific for each therapeutic approach, many hurdles were attributed to drug delivery, such as failure to deliver the treatment to the designated target with the required amounts or for the required duration of time 29,30. Regranex gel, which contains becaplermin; a recombinant angiogenic growth factor, is the first and only US-FDA approved pro-angiogenesis product.…”

Section: Angiogenesis: Overviewmentioning

confidence: 99%

<p>Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications</p>

Darweesh

Ayoub

Nazzal

2019

IJN

109

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Angiogenesis is the formation of new blood vessels from pre-existing vessels. It is a highly regulated process as determined by the interplay between pro-angiogenic and anti-angiogenic factors. Under certain conditions the balance between angiogenesis stimulators and inhibitors is altered, which results in a shift from physiological to pathological angiogenesis. Therefore, the goal of therapeutic targeting of angiogenic process is to normalize vasculature in target tissues by enhancing angiogenesis in disease conditions of reduced vascularity and blood flow, such as tissue ischemia, or alternatively to inhibit excessive and abnormal angiogenesis in disorders like cancer. Gold nanoparticles (AuNPs) are special particles that are generated by nanotechnology and composed of an inorganic core containing gold which is encircled by an organic monolayer. The ability of AuNPs to alter vasculature has captured recent attention in medical literature as potential therapeutic agents for the management of pathologic angiogenesis. This review provides an overview of the effects of AuNPs on angiogenesis and the molecular mechanisms and biomedical applications associated with their effects. In addition, the main synthesis methods, physical properties, uptake mechanisms, and toxicity of AuNPs are briefly summarized.

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Depot-Based Delivery Systems for Pro-Angiogenic Peptides: A Review

Cited by 51 publications

References 165 publications

Microchannel network hydrogel induced ischemic blood perfusion connection

Microchannel network hydrogel induced ischemic blood perfusion connection

Engineering Smart Targeting Nanovesicles and Their Combination with Hydrogels for Controlled Drug Delivery

<p>Gold nanoparticles and angiogenesis: molecular mechanisms and biomedical applications</p>

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