2020
DOI: 10.1016/j.jddst.2019.101404
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Depot lidocaine-loaded microemulsion for prolonged local anesthesia: Different efficacy model studies

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Cited by 10 publications
(10 citation statements)
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“…A centrifugation study was carried out by centrifuging the microemulsions at 3500 rpm for 30 min. The microemulsions stayed clear and transparent after centrifugation, which confirmed the mechanical stability of the microemulsion (Zhao et al, 2020). Thermodynamic stability data of the microemulsion system is demonstrated in Table 1.…”
Section: Characterization Of Microemulsionssupporting
confidence: 61%
“…A centrifugation study was carried out by centrifuging the microemulsions at 3500 rpm for 30 min. The microemulsions stayed clear and transparent after centrifugation, which confirmed the mechanical stability of the microemulsion (Zhao et al, 2020). Thermodynamic stability data of the microemulsion system is demonstrated in Table 1.…”
Section: Characterization Of Microemulsionssupporting
confidence: 61%
“…This outer layer of skin is made up of keratinized, stratified squamous epithelial cells that form a permeability barrier that prevents the movement of water [ 14 ]. Recently, lidocaine has been applied to various topical delivery dosage forms, such as microneedles and depots [ 15 , 16 ]. However, these dosage forms are difficult to use for hemorrhoids.…”
Section: Introductionmentioning
confidence: 99%
“…Ex-vivo permeation studies were carried out using rabbit ear skin obtained from local slaughterhouse and vertical diffusion Franz cells for 7 h at 37 • C. This temperature value was selected according to the results reported in literature [39,40]. The receptor solutions were maintained at 37 • C in order to assure a temperature of skin surface loaded in diffusion cell in the range 32-35 • C.…”
Section: Ex-vivo Permeation Studiesmentioning
confidence: 99%