Depot Neuroleptic Therapy: Clinical Considerations

Gj, Remington; Me, Adams

doi:10.1177/070674379504003s02

Cited by 33 publications

(2 citation statements)

References 50 publications

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“…The more consistent 12 and higher 13 bioavailability of LAIA in comparison to oral antipsychotics might result in LAIA having higher true plasma level and load than their calculated chlorpromazine equivalence. The lack of the association between the chlorpromazine equivalence and the reduction of HoNOS scores can be explained by the significant individual variations in augmenting antipsychotics which efficacy were not adequately expressed by the chlorpromazine equivalence.…”

Section: Discussionmentioning

confidence: 99%

Predictors of functioning and clinical outcomes in inpatient with schizophrenia on clozapine augmented with antipsychotics

Mukherjee

Sazhin

2021

Australas Psychiatry

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Objective: We aimed at exploring predictors of improvement in clinical and functional outcomes of patients on clozapine with chronic treatment-resistant schizophrenia admitted into rehabilitation wards. Method In a cross-sectional study of 62 patients on clozapine augmented with oral and parenteral antipsychotics, predictors of HoNOS (Health of the Nation Outcome Scales) scores were analysed using ordinal logistic regression. Result: Augmentation with parenteral antipsychotics was associated with lower psychotic symptom scores (OR 0.38 [95%CI 0.15, 0.99]) and activity of daily living scores (OR 0.36 [95%CI, 0.13, 0.96]) compared with oral antipsychotics. Increased age was a predictor of behavioural disturbances, physical illness and cognitive problems for all clozapine patients, and female gender was associated with the increase in depression scores. Conclusion: The addition of parental antipsychotics to clozapine in patients with treatment-resistant schizophrenia might have potential benefits for clinical and functional outcomes and needs a further investigation.

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Section: Discussionmentioning

confidence: 99%

Predictors of functioning and clinical outcomes in inpatient with schizophrenia on clozapine augmented with antipsychotics

Mukherjee

Sazhin

2021

Australas Psychiatry

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“…Given the potential benefits of atypical antipsychotics, it is disturbing that 59 percent of patients on conventional antipsychotics never received a trial on an atypical agent. Possible explanations for this may be prior nonadherence or substance abuse, because 56 subjects (72%) were on a depot preparation either as monotherapy or in combination with oral conventional antipsychotics, which are commonly used to manage nonadherence (Glazer and Kane 1992).…”

Section: Discussionmentioning

confidence: 99%

Who Are Patients on Conventional Antipsychotics?

Valenti¹,

Narendran²,

Pristach³

2003

Schizophrenia Bulletin

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The advent of atypical antipsychotics presented psychiatrists with an effective way of treating psychosis without the many side effects associated with conventional agents. Given the superiority of atypical antipsychotics, we examined demographic information and treatment histories of patients currently treated with conventional antipsychotics, especially in regard to treatment with atypical agents. Medication histories and demographic information for 276 patients admitted to an urban hospital were obtained by patient/family interviews and review of medical records. Chi-square and logistic regression tests were used to analyze data for possible predictive factors of which patients within the sample were still receiving conventional antipsychotics for treatment. Seventy-eight (28%) patients were currently being treated with conventional antipsychotics. More than half of them had never received a trial of an atypical agent. African-Americans, who are more likely to suffer adverse effects from conventional antipsychotics, and substance abusers were overrepresented in this group. It is unclear to what extent ethnic or cultural bias played a role in determining medication choice. Because conventional antipsychotics are associated with more side effects and greater medication nonadherence, these patients should be evaluated for appropriateness of a trial with an atypical agent even if they are currently stable with a conventional antipsychotic.

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Synthèse à partir de cinq études sur l'efficacité et la tolérance de la rispéridone à action prolongée

Vincent

2006

Annales Médico-psychologiques, revue psychiatrique

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Depot Neuroleptic Therapy: Clinical Considerations

Cited by 33 publications

References 50 publications

Predictors of functioning and clinical outcomes in inpatient with schizophrenia on clozapine augmented with antipsychotics

Predictors of functioning and clinical outcomes in inpatient with schizophrenia on clozapine augmented with antipsychotics

Who Are Patients on Conventional Antipsychotics?

Synthèse à partir de cinq études sur l'efficacité et la tolérance de la rispéridone à action prolongée

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