Deprenyl prevents MPP+-induced oxidative damage in PC12 cells by the upregulation of Nrf2-mediated NQO1 expression through the activation of PI3K/Akt and Erk

Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity

“…*P b 0.05, compared with each other. cells (Xiao et al, 2011). In contrast, our results demonstrate that exercise did not reduce the glutathione level or increase the ratio of GSSG: total glutathione (Fig.…”

ERK5/KLF4 signaling as a common mediator of the neuroprotective effects of both nerve growth factor and hydrogen peroxide preconditioning

“…The beststudied members of this family, ERK1/2, have been considered critical in promoting cell survival against oxidative stress in cultured primary neurons (Hota, Hota et al 2012;Sanchez et al 2012) as well as PC12 cells (Wruck et al 2007;Xiao et al 2011). However, these studies utilized the pharmacological inhibitors U0126 and PD98059, which have been previously used as selective inhibitors of the ERK1/2 signaling pathway but recently reported to effectively inhibit ERK5 signaling pathway as well (Suzaki et al 2004;Su et al 2011).…”

FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation

“…Oxidative stress as indicated by overproduction of H 2 O 2 , and a decrease in glutathione levels has been found in MPP þ -induced dopaminergic neurodegeneration [2,3]. Antioxidants reduce oxidative stress and demonstrate neuroprotective action against MPP þ toxicity [4][5][6]. Moreover, low levels of brain-derived neurotrophic growth factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) have been found in the SN of persons with PD and animals treated with MPP þ [7,8].…”