Depressed Function in Remote Myocardium After Myocardial Infarction: Influence of Orotic Acid

Cochrane, Andrew; Pathik, Shobhna; Smolich, Joseph J.; Conyers, R. A. J.; Rosenfeldt, Franklin

doi:10.1016/s0003-4975(96)00673-x

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…In the first few days after major acute m cardial infarction, the non-infarcted myocardium, rem from the infarct, manifests depressed contractility [3] a biochemical perturbations including decreased levels glycogen [4] and high energy phosphates [5,6]. Thus, the presence of recent infarction the surviving myocardiu when subjected to a period of cardioplegic arrest w impaired contractile function and depleted energy stor is highly vulnerable to ischemic injury.…”

Section: Introductionmentioning

confidence: 99%

Aspartate improves recovery of the recently infarcted rat heart after cardioplegic arrest

Rosenfeldt

Korchazhkina²,

Richards

et al. 1998

European Journal of Cardio-Thoracic Surgery

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Background:We have previously shown that aspartate improves the tolerance of normal hearts to cardioplegia. The aim of this st was to investigate whether aspartate is also beneficial in the recently infarcted heart. Methods: Myocardial infarction was produced in by left coronary artery ligation. Twenty hours later their hearts were perfused on an isolated working rat heart apparatus and underw cardioplegic arrest for 30 min at 37°C with or without 20 mM aspartate in the cardioplegic solution (n = 11 per group). Functional recov and myocardial high energy phosphate levels were measured at the end of arrest and after 30 min of reperfusion. Results: There was difference in pre-arrest pump function between the untreated and aspartate-treated groups. However, after reperfusion the aspartate gr generated more power (3.4 ± 0.2 mJ/s per g) than the untreated group (2.5 ± 0.3 mJ/s per g; P Ͻ 0.05) such that the percentage recovery pre-arrest power in the aspartate group (67.7 ± 3.5%) was greater than in the untreated group (53.6 ± 4.9%; P Ͻ 0.05). The aspartate gr also showed increases in aortic flow and myocardial oxygen consumption compared to the untreated group (P Ͻ 0.05). There were between-group differences in high energy phosphate levels at the end of arrest or after reperfusion. Conclusion: Aspartate impro functional recovery of the recently infarcted heart during cardioplegic arrest, and therefore has potential as a useful adjunct to myocard protection in patients with recent myocardial infarction undergoing cardiac surgery.

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Section: Introductionmentioning

confidence: 99%

Aspartate improves recovery of the recently infarcted rat heart after cardioplegic arrest

Rosenfeldt

Korchazhkina²,

Richards

et al. 1998

European Journal of Cardio-Thoracic Surgery

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Repair Of postmyocardial infarct ventricular free wall rupture using an onlay pericardial patch

Roubos

Mariani

Miller

et al. 1999

The Asia Pacific Heart Journal

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Rosenfeldt

1998

Cardiovascular Drugs and Therapy

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Orotic acid (OA), a naturally occurring substance, is a key intermediate in the biosynthetic pathway of pyrimidines. Previous investigations in the heart suggest that orotate can protect recently infarcted hearts against a further ischemic stress and may be beneficial in certain types of experimental cardiomyopathy. At the Hamburg symposium on magnesium orotate, a number of studies of this form of metabolic supplementation were presented that indicate orotic acid and its magnesium salt have a modest beneficial effect on the myocardium under conditions of stress ranging from myocardial infarction to severe physical exercise. The following conclusions can be drawn: (1) Orotic acid can improve the energy status of the recently infarcted myocardium (rat hearts). (2) Orotic acid may improve myocardial purine and pyrimidine levels by stimulating hepatic release of uridine into the bloodstream, which in turn augments depleted myocardial pyrimidines and purines (rat heart). (3) Orotic acid improves the tolerance of the recently infarcted heart to global ischemia (rats). (4) Magnesium orotate may reduce the severity of chronic myocardial dysfunction and structural damage in cardiomyopathy (cardiomyopathic hamsters). (5) Magnesium orotate may improve exercise tolerance in patients with coronary artery disease and in trained athletes (humans). (6) Magnesium orotate has only a weak inotropic effect, if any, on normal hearts (rats). (7) Further clinical testing is indicated to determine if the effects described could be of significant clinical benefit in the treatment of heart disease.

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Depressed Function in Remote Myocardium After Myocardial Infarction: Influence of Orotic Acid

Cited by 3 publications

References 27 publications

Aspartate improves recovery of the recently infarcted rat heart after cardioplegic arrest

Aspartate improves recovery of the recently infarcted rat heart after cardioplegic arrest

Repair Of postmyocardial infarct ventricular free wall rupture using an onlay pericardial patch

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