2017
DOI: 10.1097/yco.0000000000000350
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Depressed gut? The microbiota-diet-inflammation trialogue in depression

Abstract: The review summarizes the existent literature on this emerging research field and provides a comprehensive overview of the multifaceted links between the microbiota, diet, and depression. Several pathways linking early life trauma, pharmacological treatment effects, and nutrition to the microbiome in depression are described aiming to foster the psychotherapeutic treatment of depressed patients by interventions targeting the microbiota.

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Cited by 96 publications
(80 citation statements)
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“…An abnormally high-fat diet is associated with oesophageal acid exposure and gastro-oesophageal reflux, which elevate the risk of peptic ulcer disease 26,27 . Moreover, the unbalanced diet that is often associated with depression patients may influence the gut microbiota, which increases the risk of peptic ulcer disease 28 . On the other hand, chronic gastric pain and stress related to the disease burden of peptic ulcer disease could elevate the risk of depression.…”
Section: Discussionmentioning
confidence: 99%
“…An abnormally high-fat diet is associated with oesophageal acid exposure and gastro-oesophageal reflux, which elevate the risk of peptic ulcer disease 26,27 . Moreover, the unbalanced diet that is often associated with depression patients may influence the gut microbiota, which increases the risk of peptic ulcer disease 28 . On the other hand, chronic gastric pain and stress related to the disease burden of peptic ulcer disease could elevate the risk of depression.…”
Section: Discussionmentioning
confidence: 99%
“…Neuroinflammation can be involved in these circuits because changes in intestinal permeability facilitate the recognition of bacterial lipopolysaccharide by toll-like receptors on the surfaces of the immune cells of the intestinal mucosa. This elicits the secretion of pro-inflammatory cytokines, which in turn causes an inflammatory response in the brain [237,238]. Interestingly, alterations in the physiology of the brain-gut axis are also present in PD and AD.…”
Section: Depressionmentioning
confidence: 99%
“…These gut bacteria has coevolved with the human body to perform numerous beneficial functions ranging from being simple fermenters of food to having profound effects on the host immune development, metabolism and food preferences, brain development, stress responses, pain and behavior [1][2][3][4][5]. Consequently, disruptions or alterations in this resilient relationship is a significant factor in many diseases such as inflammatory gastrointestinal diseases, and neuropsychiatric disorders, including depression [1,[6][7][8].…”
Section: Introductionmentioning
confidence: 99%