Depressed Rh phenotypes

Tippett, Patricia

doi:10.1016/s0338-4535(78)80037-3

Cited by 10 publications

(5 citation statements)

References 14 publications

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“…The cells of her father (1)(2)(3)(4) showed the same reduction of reactivity with anti-C sera as those of the proposita. The cells of the father and the eldest brother (IT6) also gave weak reactions with anti-E sera (table III).…”

Section: Rh Antigens Of the Ol(a+) Family Membersmentioning

confidence: 82%

“…The same Rh gene complexes that code for the production of these Rh anti gens also code for the production of the rare antigens. Infrequent antigens as Dw(Rh23), Goa(Rh30), Rh32, Rh33, Rh35, Bea(Rh36), Evans (Rh37) and Tar (Rh40) provide examples of this mechanism [1][2][3][4][5]. However, unlinked regulator or modifying genes may also lead to an abolished [6] or reduced [7] expression of Rh antigens in people with 'normal' Rh gene complexes [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

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A Rare Blood Group Antigen, Ol^a (Oldeide), Associated with Weak Rh Antigens

Kornstad¹

1986

Vox Sanguinis

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A ‘new’, rare blood group antigen, Ol^a (Oldeide), is described. Only one Ol(a+) person was found among the 7,151 blood donors tested. Examination of the family of the proposita revealed 10 additional Ol(a+) persons. The study indicated that Ol3 is inherited as a Mendelian dominant character and segregates independently of the ABO, MNSs, P, Rh and Kidd blood group systems, of the ABH secretor genes, and of sex. Ol(a+) family members had depressed Rh antigens, while the Ol(a-) members had Rh antigens of normal strength. The depression was particularly pronounced for the C and E antigens, less marked for the D antigen. Individual antisera differed in their ability to demonstrate the presence of the antigens. Depression of the c and e antigens could not be demonstrated conclusively with the antisera available.

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Section: Rh Antigens Of the Ol(a+) Family Membersmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

A Rare Blood Group Antigen, Ol^a (Oldeide), Associated with Weak Rh Antigens

Kornstad¹

1986

Vox Sanguinis

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“…His RBCs reacted with six of seven of the immune sera that had given positive reactions with other unrelated Rh mod samples. 19…”

Section: The Presence Of E Antigen On Rbcs Of Ii-1 Was Confirmed By Adsorption and Elution Tests; Anti-e Was Eluted From Ii-1's Cells Coamentioning

confidence: 99%

Rh_mod phenotype: a parentage problem solved by denaturing gradient gel electrophoresis of genomic DNA

Steers¹,

Wallace²,

Mora

et al. 1996

Immunohematology

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Initial Rh phenotyping of a man with hemolytic anemia, his wife, and son appeared to exclude paternity. No exclusion was found in other blood groups or in the human leukocyte antigen (HLA) system; excluding Rh, the paternity index was 98.58 percent. Samples from these three family members, and two other family members, were tested with additional Rh antisera. The results indicated that the propositus has an Rhmod phenotype with expression of c, weak e, and very weak D, E, and G antigens. To support this hypothesis, DNA analysis of the RHD and RHCE genes was performed on the five family members. Polymerase chain reaction (PCR) products from exons 2 and 5 were analyzed by denaturing gradient gel electrophoresis (DGGE). The DNA results corroborated the serologic findings and refuted the exclusion of paternity.

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“…A possible explanation is that the Ola gene influences the Rh antigen expression. It is well known that there are unlinked, modifying genes that have a suppressor effect on the Rh system [1][2][3]6,7]. Ola, or a closely linked gene, might be such a modifying gene.…”

Section: -4mentioning

confidence: 99%

A Rare Blood Group Antigen, Ol^a (Oldeide), Associated with Weak Rh Antigens¹

Kornstad¹

1986

Vox Sanguinis

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A 'new', rare blood group antigen, Ola (Oldeide), is described. Only one Ol(a+) person was found among the 7,151 blood donors tested. Examination of the family of the proposita revealed 10 additional Ol(a+) persons. The study indicated that Ola is inherited as a Mendelian dominant character and segregates independently of the ABO, MNSs, P, Rh and Kidd blood group systems, of the ABH secretor genes, and of sex. Ol(a+) family members had depressed Rh antigens, while the Ol(a-) members had Rh antigens of normal strength. The depression was particularly pronounced for the C and E antigens, less marked for the D antigen. Individual antisera differed in their ability to demonstrate the presence of the antigens. Depression of the c and e antigens could not be demonstrated conclusively with the antisera available.

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Depressed Rh phenotypes

Cited by 10 publications

References 14 publications

A Rare Blood Group Antigen, Ol^a (Oldeide), Associated with Weak Rh Antigens

A Rare Blood Group Antigen, Ol^a (Oldeide), Associated with Weak Rh Antigens

Rh_mod phenotype: a parentage problem solved by denaturing gradient gel electrophoresis of genomic DNA

A Rare Blood Group Antigen, Ol^a (Oldeide), Associated with Weak Rh Antigens¹

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Depressed Rh phenotypes

Cited by 10 publications

References 14 publications

A Rare Blood Group Antigen, Ol^a (Oldeide), Associated with Weak Rh Antigens

A Rare Blood Group Antigen, Ol^a (Oldeide), Associated with Weak Rh Antigens

Rhmod phenotype: a parentage problem solved by denaturing gradient gel electrophoresis of genomic DNA

A Rare Blood Group Antigen, Ola (Oldeide), Associated with Weak Rh Antigens1

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Rh_mod phenotype: a parentage problem solved by denaturing gradient gel electrophoresis of genomic DNA

A Rare Blood Group Antigen, Ol^a (Oldeide), Associated with Weak Rh Antigens¹