Depression

McCarron, Robert M.; Shapiro, Bryan; Rawles, Jody; Luo, John

doi:10.7326/aitc202105180

Cited by 265 publications

(137 citation statements)

References 59 publications

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“…Depression is a prevalent mental condition that is characterized by depressed mood, anhedonia, fatigue or loss of energy, weight loss, psychomotor retardation or agitation ( 1 , 2 ). It affects 15-18% of the population and is generally more prevalent in women ( 3-5 ).…”

Section: Introductionmentioning

confidence: 99%

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Effects of chronic folate deficiency and sex differences on depression‑like behavior in mice

Sun

Qing

et al. 2022

Exp Ther Med

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Although previous studies have reported that serum folate levels are negatively associated with depression in women but not men, it remains unclear whether folate deficiency can directly lead to depression and whether sex difference serves a role in this condition, since the potential mechanism remains elusive. Therefore, the present study aimed to investigate whether folate deficiency results in differences in parameters associated with depression between males and females. CD-1 mice received either a standard control diet or a folate-deficient diet from 10 to 38 weeks of age, following which behavioral assays, such as an open field test, sucrose preference test and forced swim test were performed throughout week 38. Serum and cerebral cortex samples were subsequently collected for assessment. Serum folate, homocysteine, estradiol (E2) and testosterone levels were measured using chemiluminescence, enzymatic cycling assay and electrochemiluminescence immunoassays. The cerebral cortex was used for western blot analysis, to detect the expression levels of estrogen receptor β (ERβ), PI3K/AKT pathway and caspase-3. The results revealed that compared with those in female mice that received standard control diet, female mice that received folate-deficient diet exhibited lower E2 concentrations, lower sucrose preferences (as determined through the sucrose preference test), longer durations of immobility (as determined in the forced swim test) and less time spent in the central areas of the open field test. Western blotting demonstrated that the expression levels of ERβ and the phosphorylation levels of PI3K and AKT were decreased, whilst the expression levels of cleaved caspase-3 were increased, in the cerebral cortex of female mice that received folate-deficient diet. However, no differences in E2 concentration, behavioral assay parameters or protein levels of ERβ, phosphorylated (p-)PI3K, p-AKT and cleaved caspase-3 could be observed in male mice regardless of whether they received standard control or folate-deficient diets. Collectively, these results revealed that folate deficiency only led to depression-like behavior in female mice. This may be associated with reduced E2 levels, which may inhibit the PI3K/AKT pathway and upregulate the expression of cleaved caspase-3 to promote neuronal apoptosis.

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Section: Introductionmentioning

confidence: 99%

“…Depression is a leading cause of reduction in the quality of life. Furthermore, the World Health Organization projected that depression would rank as the leading contributor to the global burden of disease by 2030 ( 1 , 2 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of chronic folate deficiency and sex differences on depression‑like behavior in mice

Sun

Qing

et al. 2022

Exp Ther Med

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“…Our findings showed that the incidence of SLE patients with anxiety was 22%, much higher than that of normal adults (10-14%) (26) and more likely to have symptoms of fatigue and depression. Anxiety, depression, and fatigue often co-exist as manifestations of each other (27,28). Previous studies have shown that fatigue is strongly associated with anxiety and depression in SLE and RA patients (29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

Relevant Characteristics Analysis Using Natural Language Processing and Machine Learning Based on Phenotypes and T-Cell Subsets in Systemic Lupus Erythematosus Patients With Anxiety

Jin

et al. 2021

Front. Psychiatry

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Anxiety is frequently observed in patients with systemic lupus erythematosus (SLE) and the immune system could act as a trigger for anxiety. To recognize abnormal T-cell and B-cell subsets for SLE patients with anxiety, in this study, patient disease phenotypes data from electronic lupus symptom records were extracted by using natural language processing. The Hospital Anxiety and Depression Scale (HADS) was used to distinguish patients, and 107 patients were selected to meet research requirements. Then, peripheral blood was collected from two patient groups for multicolor flow cytometry experiments. The characteristics of 75 T-cell and 15 B-cell subsets were investigated between SLE patients with- (n = 23) and without-anxiety (n = 84) groups by four machine learning methods. The findings showed 13 T-cell subsets were significantly different between the two groups. Furthermore, BMI, fatigue, depression, unstable emotions, CD27+CD28+ Th/Treg, CD27−CD28− Th/Treg, CD45RA−CD27− Th, and CD45RA+HLADR+ Th cells may be important characteristics between SLE patients with- and without-anxiety groups. The findings not only point out the difference of T-cell subsets in SLE patients with or without anxiety, but also imply that T cells might play the important role in patients with anxiety disorder.

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“…The number of global depression cases increased from 172 million in 1990 to 258 million in 2017 ( 2 ). The common risk factors for depression include serious or chronic diseases, personal or family histories of depression, and traumatic or stressful events ( 3 ). Sleep is also a useful marker for the occurrence of depression ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Sleep Efficiency May Predict Depression in a Large Population-Based Study

et al. 2022

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Objectives:The purpose of our study was to investigate the effect of objective sleep characteristics on the incidence of depression.MethodsThe participants of our study (1,595 men and 1,780 women with 63.1 ± 10.7 years) were selected from the Sleep Heart Health Study (SHHS) datasets. Depression was defined as the first occurrence between SHHS visit 1 and visit 2. Objective sleep characteristics, including sleep efficiency (SE), wake after sleep onset (WASO), sleep fragmentation index (SFI) and arousal index (ArI), were monitored by polysomnography. Multivariable logistic regression was used to explore the relationship between sleep characteristics and depression.ResultsA total of 248 patients with depression (7.3%) were observed between SHHS visits 1 and 2. After adjusting for covariates, SE (odds ratio [OR], 0.891; 95% confidence interval [CI] 0.811–0.978; P = 0.016) and WASO (OR, 1.021; 95% CI 1.002–1.039; P = 0.026) were associated with the incidence of depression. Moreover, the relationship between SE and depression was more pronounced in men (OR, 0.820; 95% CI 0.711–0.946; P = 0.007) than in women (OR, 0.950; 95% CI 0.838–1.078; P = 0.429) in subgroup analysis (Pinteraction < 0.05).ConclusionsSE and WASO may be markers for the incidence of depression. The association between SE and depression was intensified in men.

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Depression

Cited by 265 publications

References 59 publications

Effects of chronic folate deficiency and sex differences on depression‑like behavior in mice

Effects of chronic folate deficiency and sex differences on depression‑like behavior in mice

Relevant Characteristics Analysis Using Natural Language Processing and Machine Learning Based on Phenotypes and T-Cell Subsets in Systemic Lupus Erythematosus Patients With Anxiety

Sleep Efficiency May Predict Depression in a Large Population-Based Study

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