Depression and aging with HIV: Associations with health-related quality of life and positive psychological factors

Abstract

Background: Depression is prevalent among persons living with HIV (PLWH). This study investigated the relationships between depressive symptomatology, health-related quality of life (HRQoL), and positive psychological factors in PLWH and age-matched HIV−individuals. Methods: One hundred twenty-two PLWH and 94 HIV− individuals, recruited in three age cohorts (36-45, 46-55, 56-65 years old), completed self-report questionnaires on depressive symptoms (CES-D), HRQoL, and positive psychological factors (resilience, grit, and self-rated successful aging [SRSA]). Participants were classified based on HIV status (H+ vs H−) and elevated depressive symptoms (D+ vs D−) into four groups (H+/D+; H−/D+; H+/D−; H−/D−). Results: Fifty-eight percent of PLWH had elevated depressive scores, compared to 33% of HIV-individuals (p < 0.001). The proportion of individuals reporting elevated depressive symptoms only differed among individuals 36-45 years old (H+: 61.5%; H−: 17.9%; p < 0.001). Individuals in the H+/D+ group reported the lowest HRQoL, resilience, grit, and SRSA across age cohorts. However, there were no differences on HRQoL or positive psychological factors between H+/D-and H-/ D-groups; in fact, individuals 56-65 years in the H+/D-group endorsed aging the most successfully. Limitations: Small sample size within the groups and the cross-sectional nature of the analysis limit the ability to address onset of depressive symptoms in relation to HRQoL or positive psychological factors. Conclusions: Among PLWH depressive symptoms show a strong association with HRQoL and positive psychological factors compared to HIV-individuals. In the absence of elevated depressive symptoms, however, PLWH report similar HRQoL and positive psychological factors to HIV-individuals.

Pre-frailty predicts cognitive decline at 2-year follow-up in persons living with HIV

“…Participants were 50 PLWH and 60 HIV-uninfected (HIV−) individuals enrolled in the Multi-Dimensional Successful Aging among HIV-Infected Adults study conducted at the University of California, San Diego (UCSD) (Moore et al, 2018, Rooney et al, 2019. All participants were aged 35 to 65 at baseline, consistent with study recruitment goals.…”

Social support moderates D-dimer and self-rated successful aging within people with HIV and older adults

“…Two hundred and thirty individuals (134 PWH and 96 HIVseronegative) were drawn from a longitudinal cohort study of aging at the University of California, San Diego (UC San Diego; the Multi-Dimensional Successful Aging Among HIV-Infected Adults study; Moore et al, 2018;Rooney et al, 2019). All participants were between 36 and 65 years of age at baseline and were recruited into age cohorts by decade (i.e., ages 36-45, 46-55, and 56-65 years).…”

“…While SA is important for all aging adults, in recent years, interest in understanding and promoting SA among people with HIV (PWH) has been gaining momentum (Rooney et al, 2019;Rueda, Law, & Rourke, 2014;Vance et al, 2019;Wallace et al, 2017). Following the introduction of combination antiretroviral therapy in 1996, many PWH are now approaching older adulthood and have life expectancies approximating those among individuals of the general population (Antiretroviral Therapy Cohort, 2017).…”

Prevalence and factors associated with severe depressive symptoms in older West African people living with HIV

“…Its occurrence leads to alteration of economic productivity, unemployment (20,23), social isolation, stigmatization (24), disability (25), and also high sexual risk behaviors (26). In western countries, untreated depression in PLHIV has also been related to increased cognitive complaints and negative consequences in multiple aspects of quality of life (27)(28)(29).…”