Depression and anxiety in patients with hepatitis C: prevalence, detection rates and risk factors

The effects of HCV infection and management on health-related quality of life

“…In this study, 92 (58.6%) patients had clinical evidence of depression, resulting in significantly lower scores in all 8 domains of the SF-36 compared with patients without depression. 22 Similar to the findings of Golden et al, 41 these results point to the deleterious effect of depression on well-being in patients with CHC. 22 Cognitive Impairment.…”

“…In addition, depression was associated with lower work and social adjustment, lower acceptance of illness, higher illness-related stigma, worsened illness-related memory and concentration, and higher rates of subjective physical symptoms (all P Ͻ 0.05). 41 These results were confirmed by Gallegos-Orozco et al, 22 who assessed HRQL and depression in 157 treatment-naïve patients with CHC who were aware of their HCV serostatus. In this study, 92 (58.6%) patients had clinical evidence of depression, resulting in significantly lower scores in all 8 domains of the SF-36 compared with patients without depression.…”

“…Depression is another common feature of CHC that, like fatigue, may affect HRQL. To determine rates of depression and other mood disorders, Golden et al 41 administered the Structured Clinical Interview for DSM-IV Axis I Disorders: Clinician Version to 90 HCV-positive patients awaiting IFN therapy. Rates of depression (28%) and anxiety disorders (24%) were higher in study patients than in the general population.…”

Review article: depression and the use of antidepressants in patients with chronic liver disease or liver transplantation

“…21,22 Even accounting for these neuropsychiatric symptoms, depression per se is more prevalent in hepatitis C patients than in the general population. Major depression has been reported in 15-49.5% of patients with chronic HCV infection, independent of the use of anti-viral treatment, [23][24][25][26] with a mean prevalence of 38% found in a review across 10 studies. 27 Of these patients, a significant proportion (up to 72%) had not been identified as having depression previously.…”

“…27 Of these patients, a significant proportion (up to 72%) had not been identified as having depression previously. 26 Multi-variate regression analysis of a large cohort of patients with chronic liver disease of different aetiologies (HCV, hepatitis B (HBV), alcohol-related liver disease and non-alcoholic fatty liver disease (NAFLD), both cirrhotic and noncirrhotic), who were screened for depression using the Patient Health Questionnaire-9 (PHQ-9) questionnaire, identified HCV only as an independent risk factor for depression. 28 There are a number of potential explanations for this relationship.…”