Depression and anxiety in relation to cancer incidence and mortality: a systematic review and meta-analysis of cohort studies

Wang, Yunhe; Li, Jinqiao; Shi, Jufang; Que, Jian-Yu; Li, Jiajia; Lappin, Julia; Leung, Janni; Ravindran, Arun; Chen, Wanqing; Qiao, You‐Lin; Shi, Jie; Lü, Lin; Bao, Yanping

doi:10.1038/s41380-019-0595-x

Cited by 493 publications

(388 citation statements)

References 91 publications

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“…The burden of disease in terms of years lived with disability (YLD) attributable to anxiety disorders relatively increased by 14.8% from 2005 to 2015, ranking ninth in the world ( GBD 2015 Disease and Injury Incidence and Prevalence Collaborators, 2016 ). In addition, anxiety disorders may increase the risk of cancer, cardiovascular disease, and even mortality ( Batelaan et al, 2016 ; Miloyan et al, 2016 ; Wang et al, 2019 ). Previous study has revealed individuals with high health anxiety are prone to misinterpreting harmless bodily sensations and changes as evidence that they are infected in the context of a viral outbreak or pandemic, this will, in turn, increase their anxiety, influence their ability to make rational decisions, and impact their behavior ( Asmundson and Taylor, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and factors for anxiety during the coronavirus disease 2019 (COVID-19) epidemic among the teachers in China

Miao

Zeng

et al. 2020

Journal of Affective Disorders

211

192

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Highlights The overall prevalence of anxiety was 13.67% during the Coronavirus Disease 2019 epidemic among the teachers in China. The prevalence was higher for women than men (13.89% vs. 12.93%). After adjusting for potential confounders, age, sex, education status, type of teachers, school location, information source, worried level, fear level, and behavior status were found to be associated with anxiety.

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Section: Introductionmentioning

confidence: 99%

Prevalence and factors for anxiety during the coronavirus disease 2019 (COVID-19) epidemic among the teachers in China

Miao

Zeng

et al. 2020

Journal of Affective Disorders

211

192

View full text Add to dashboard Cite

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“…[2][3][4] A meta-analysis of 70 studies involving 10 071 individuals with cancer in oncological and hematological settings reported that the prevalence of major depression as defined by Diagnostic and Statistical Manual of Mental Disorders criteria (assessed in 52 of the studies) was 14.9% (95% confidence interval [CI] 12.2-17.7). 3 Importantly, depression in patients with cancer is associated with an elevated risk of cancer mortality 5 and an up to 24-fold greater risk of suicide or death by external injury, particularly in the first week after cancer diagnosis. 6,7 Depression also reduces adherence to cancer treatments, 8 is a psychological burden on the family, 9 and increases healthcare utilization, including hospitalizations.…”

Section: Introductionmentioning

confidence: 99%

Risk of major depressive disorder in Japanese cancer patients: A matched cohort study using employer‐based health insurance claims data

et al. 2020

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Objective: Patients with cancer are at high risk of depression. However, the risk of major depressive disorder (MDD) after cancer diagnosis has not been studied in a population setting in Japan. This cohort study used a Japanese medical claims database to examine time to MDD in cancer patients and the risk of MDD (hazard ratio; HR) compared with matched cancer-free controls. Methods: Primary endpoint was time to MDD (starting 6 months before cancer diagnosis) in adult (18-74 years) cancer patients; secondary endpoint was time to MDD (6 months before to 12 months after cancer diagnosis) in a matched cohort of cancer patients and cancer-free controls. Multivariate analyses were performed to determine HRs for all cancers and for each cancer site. Results: Of 35 008 cancer patients (mean age, 53.3 years), 2201 (6.3%) were diagnosed with MDD within 66 months. Matched cancer patients (n = 30 372) had an elevated risk of MDD compared with cancer-free controls (n = 303 720; HR [95% confidence interval] 2.96 [2.77-3.16]). MDD risk was highest in patients with multiple cancers, pancreatic cancer, and brain cancer. Compared with middle-aged patients, risk was higher in patients <40 years old and lower in patients ≥65 years old; risk tended to be higher in women than in men. Conclusions: Compared with cancer-free individuals, Japanese patients with cancer, mostly <65 years old, had an almost threefold higher risk of developing MDD within 12 months of cancer diagnosis. Physicians should watch for MDD in cancer patients and treat when necessary.

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“…Evidence regarding the association between psychiatric disorders and subsequent onset of ovarian cancer remains controversial. A recent meta-analysis aggregating 3 cohorts reported a null association of depression and anxiety with ovarian cancer incidence (RR = 1.08, 95%CI: 0.93-1.24); [39] while a prospective study aggregating two US cohorts identi ed depression assessed 2-4 years before cancer diagnosis is associated with an increased risk of ovarian cancer (HR = 1.30, 95%CI: 1.05-1.60). [40] Our MR found no evidence for an association of depression/anxiety with risk of either overall or serous ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

Do Psychiatric Disorders Influence the Risk of Female Cancer? Results From a Genetic Study

Zhu

Zhang

Niu

et al. 2020

Preprint

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Background: Depression and anxiety contribute to an increased global burden of disease and affect women more often than men. Despite evidence from experimental data showing a shared biological mechanism involved in both mental health disorders and female hormone-dependent cancers, results from epidemiological investigations remain inconsistent.Methods: We aim to understand a putative causal relationship between psychological distress and female malignancy by conducting a two-sample Mendelian randomization (MR) analysis. We used summary statistics from the hitherto largest genome-wide association studies (GWAS) performed in depression (Ncase=246,363), anxiety (Ncase=44,465), breast (Ncase=122,977) and ovarian (Ncase=25,509) cancer. We constructed strong instruments using the 102 depression-associated SNPs, the 6 anxiety-associated SNPs, and applied several MR approaches.Results: We found that genetic predisposition to depression significantly increased the risk of both overall breast cancer (OR [95%CI] = 1.10 [1.03-1.18]) and its estrogen receptor (ER)- subtype (1.12 [1.01-1.24]), while a borderline significance was observed for ER+ subtype (1.08 [0.99-1.18]). These findings were corroborated by our genetic correlation analysis where a significantly shared genetic basis was observed for depression and breast cancer. On the contrary, we did not identify any causal association of anxiety with breast cancer. None of the mental health traits were associated with the onset of ovarian cancer or its serous subtype. Sensitivity analyses using different sets of instruments revealed consistent results.Conclusions: Our findings suggest that poor mental health condition such as major depression disorder is likely to be causally associated with the development of breast cancer, providing evidence supporting for the potential deleterious consequence of mental illness on cancer onset.

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Depression and anxiety in relation to cancer incidence and mortality: a systematic review and meta-analysis of cohort studies

Cited by 493 publications

References 91 publications

Prevalence and factors for anxiety during the coronavirus disease 2019 (COVID-19) epidemic among the teachers in China

Prevalence and factors for anxiety during the coronavirus disease 2019 (COVID-19) epidemic among the teachers in China

Risk of major depressive disorder in Japanese cancer patients: A matched cohort study using employer‐based health insurance claims data

Do Psychiatric Disorders Influence the Risk of Female Cancer? Results From a Genetic Study

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