Depression and anxiety symptoms among people with rifampicin-resistant tuberculosis receiving in-patient care in the National Pulmonology Reference Institute in Romania

Abstract

Mental health comorbidities are common among tuberculosis patients, with higher prevalence among people with rifampicin-resistant/multidrug-resistant (RR/MDR) tuberculosis. TB and depression share common risk factors adding to the overall disease burden. There is limited evidence about prevalence of depression and anxiety symptoms among tuberculosis patients in Romania. We assessed the prevalence of depression and anxiety symptoms and their evolution over the course of the treatment in RR/MDR-TB patients receiving in-patient care at the National Institute of Pneumonology (NIP) “Marius Nasta” in Romania during May-September 2020. We conducted a cohort study and used the Hospital Anxiety and Depression Scale (HADS) to assess the prevalence of depression and anxiety (defined as score≥ 8) symptoms at admission (baseline) and the second month of in-patient treatment (follow-up). Difference between baseline and follow-up depression and anxiety symptoms were assessed using McNemar test. Binary logistic regression was used to evaluate the association between sociodemographic and clinical characteristics with the presence of depression and anxiety symptoms at baseline. The cohort included 46 patients, 63% were male, mean age was 46 (±13.3) years. The prevalence of depression and anxiety in our cohort was 46% and 43% at baseline respectively, and 50% and 39%, at the follow-up respectively. About one third (7/25) of patients who had normal HADS depression score at baseline, had an increase above the threshold at the second month of treatment. No statistical difference in prevalence of depression or anxiety was found between the baseline and second month of treatment. Unadjusted analysis showed that odds of depression at baseline was lower in patients with education above 8th grade compared to patients with education below 8th grade (odds ratio=0.2, 95% confidence interval: 0.1,0.8, p=0.026). The study revealed high prevalence of depression and anxiety among RR/MDR-TB patients admitted to the NIP, underlining the necessity of evaluating the mental health of TB patients and linking them to appropriate care.

Anxiety and depression level of patients with multidrug-resistant tuberculosis (MDR-TB) in two hospitals in Banten province, Indonesia

“…This wide variation, globally and locally, is not surprising concerning the use of different instruments, and cut-off points for defining depression, disease stages, treatment stages, and other differences in study settings. Regarding anxiety, previous global studies show different prevalences ranging from 12%--54% [ [27] , [28] , [29] , [30] ]. In Indonesia, Fitrianur, Soeharto, and Supriati [ 31 ] found a 62% prevalence of anxiety in a hospital-setting population in East Java.…”

Spatio‐Temporal Pattern of Tuberculosis Distribution in Romania and Particulate Matter Pollution Associated With Risk of Infection

“…Another research direction of our study aims to analyze age‐gender paternity in the frequency of tuberculosis cases. Most studies point out that the main factors that induce an increase in tuberculosis cases are malnutrition, poverty, diabetes, smoking and air pollution, with no correlation identified with gender or age (Lee et al., 2020 ; Noubiap et al., 2019 ; Reid et al., 2019 ; Stoichita et al., 2021 ). The statistically analyzed data show a distribution of pulmonary tuberculosis cases in favor of men, similar to other studies in the literature, probably as a result of the social characteristics that the male sex has: involvement in heavy work, choice of jobs involving longer commutes, excluding a genetic determinism component in the increased prevalence (Shaweno et al., 2021 ).…”

Pathogenesis, Prophylaxis, and Treatment of Candida auris

“…A significant increase in new instances of colonization and infection has been detected as a result of the coronavirus disease 2019 (COVID-19) pandemic, which has altered the landscape of C. auris illness [ 2 , 17 ]. This increase is mostly attributable to the overburden of global healthcare systems and the resulting weakening of infection prevention and control procedures [ 2 , 18 ].…”