Depression and anxiety symptoms are associated with prooxidant-antioxidant balance: A population-based study

Shafiee, Mojtaba; Ahmadnezhad, Mahsa; Tayefi, Maryam; Arekhi, Soheil; Vatanparast, Hassanali; Esmaeili, Habibollah; Moohebati, Mohsen; Ferns, Gordon A.; Mokhber, Naghmeh; Arefhosseini, Seyed Rafie; Ghayour‐Mobarhan, Majid

doi:10.1016/j.jad.2018.05.079

Cited by 45 publications

(29 citation statements)

References 53 publications

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“…Studies to date indicate that patients with depression have lower levels of antioxidative systems, and at the same time, they display an increased amount of oxidative stress markers when compared with healthy individuals (147,148). Some antioxidant therapeutics, like N-acetyl-cysteine, seem to show some effect in depression treatment (149).…”

Section: Oxidative Stress Depression and Curcuminmentioning

confidence: 99%

Curcumin in Depression: Potential Mechanisms of Action and Current Evidence—A Narrative Review

2020

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Major depressive disorder (MDD) is one of the most prevalent and debilitating disorders. Current available treatments are somehow limited, so alternative therapeutic approaches targeting different biological pathways are being investigated to improve treatment outcomes. Curcumin is the main active component in the spice turmeric that has been used for centuries in Ayurvedic medicine to treat a variety of conditions, including anxiety and depressive disorders. In the past decades, curcumin has drawn researchers' attention and displays a broad range of properties that seem relevant to depression pathophysiology. In this review, we break down the potential mechanisms of action of curcumin with emphasis on the diverse systems that can be disrupted in MDD. Curcumin has displayed, in a number of studies, a potency in modulating neurotransmitter concentrations, inflammatory pathways, excitotoxicity, neuroplasticity, hypothalamic–pituitary–adrenal disturbances, insulin resistance, oxidative and nitrosative stress, and endocannabinoid system, all of which can be involved in MDD pathophysiology. To date, a handful of clinical trials have been published and suggest a benefit of curcumin in MDD. With evidence that is progressively growing, curcumin appears as a promising alternative option in the management of MDD.

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Section: Oxidative Stress Depression and Curcuminmentioning

confidence: 99%

Curcumin in Depression: Potential Mechanisms of Action and Current Evidence—A Narrative Review

2020

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“…In addition to endogenous oxidative stress, reasons of exogenous oxidative stress such as smoking, emotional stress, ultraviolet exposure, some chemicals, inflammation, pollution, and genetic defects activate and accelerate this process 4,12 . Psychological disorders such as anxiety and depression may play roles in the etiopathogenesis of PHG by increasing exogenous oxidative stress 17,31 . Akın Belli et al reported that emotional stress was higher in PHG 22 .…”

Section: Discussionmentioning

confidence: 99%

“…Total oxidant status (TOS) and total antioxidant status (TAS) reflect global assessment of oxidative stress 15,16 . In addition, psychological disorders may increase oxidative stress 17 . In this study, we aimed to evaluate the oxidative stress status globally in PHG through measuring TOS and TAS in serum of individuals of PHG and emotional stress and anxiety levels.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of oxidative stress and psychoemotional status in premature hair graying

Acer

Erdoğan

Kocatürk

et al. 2020

J of Cosmetic Dermatology

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Background Hair graying is a natural process in aging and is not usually associated with a medical problem. It sometimes may occur at early age and is called premature hair graying (PHG). Pathogenesis of PHG is not clear but it was associated with various systemic diseases such as coronary artery diseases, osteopenia, and hypothyroidism. Objectives The purpose of this study was to evaluate the oxidative stress and psychoemotional status in individuals with PHG. Methods Sixty participants with PHG and 60 healthy volunteers aged between 18 and 20 years were included in the study. Total oxidant status (TOS), total antioxidant status (TAS) levels measured in serum, and oxidative stress index (OSI) were calculated. Participants were asked to complete Perceived Stress Scale (PSS) and Beck Anxiety Index (BAI). Results Total oxidant status, OSI, and PSS scores were significantly higher in the PHG group (P < .001). There was no significant difference between severity of PHG and TAS, TOS, and OSI (P > .05). There was a significant relationship between BAI scores and TOS and OSI in PHG group (P = .03, P = .049, respectively). Conclusion Oxidative and emotional stress may play a role in pathogenesis of PHG. Our study showed that serum oxidative stress and emotional stress were high in PHG. In other words, there was high systemic oxidative stress in PHG.

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“…The brain is especially susceptible to oxidative stress and antioxidants defend against the negative effects of oxidative stress in brain (Payne et al, 2012). Another underlying mechanism that may be responsible for this effect is that antioxidants have beneficial effects upon oxidative and inflammatory markers, which are often elevated during depression (Shafiee et al, 2017(Shafiee et al, , 2018Tayefi et al, 2017). A cohort study examined the relationship between high fruit and vegetable consumption and psychological behavior.…”

Section: Discussionmentioning

confidence: 99%

Dietary intake of carotenoids and fiber is inversely associated with aggression score in adolescent girls

et al. 2019

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Background: Violence and aggression are considered to be important public health issues. There is limited data on the association between dietary intake and aggression score. Aim: We aimed to examine the relationship between the dietary intake and aggressive behavior in Iranian adolescent girls. Methods: The study was carried out among 670 girls aged 12–18 years. A valid and reliable food frequency questionnaire (FFQ) containing 147 food items was used to estimate dietary intake of the study participants. Aggression score was determined using a validated Persian version of the Buss–Perry questionnaire. We analyzed our data using crude and adjusted models. Results: Participants in the fourth quartile of aggression score had significantly higher energy intake compared with those in the first quartile (2808±949 vs 2629±819, p-trend = 0.01). Dietary intakes of soluble fiber (0.42±0.37 vs 0.35±0.29, p = 0.03) and insoluble fiber (2.17±1.65 vs 1.82±1.36, p = 0.02) were significantly higher in the first quartile than in the fourth quartile. In addition, the strongest negative correlations were found between aggression score and dietary soluble fiber ( p = 0.003) and insoluble fiber intake ( p = 0.001). Moreover, aggression score was negatively correlated with dietary α-carotene ( p = 0.02) and β-carotene ( p = 0.04) intake. These associations remained significant even after adjustment for potential confounders. Conclusions: Our results indicated that dietary intakes of fiber, α-carotene, and β-carotene were inversely associated with aggression score. Moreover, a significant positive association was observed between energy intake and aggression score in adolescent girls.

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Depression and anxiety symptoms are associated with prooxidant-antioxidant balance: A population-based study

Abstract: Symptoms of depression and anxiety appear to be associated with higher degrees of oxidative stress, expressed by higher serum PAB values.

Cited by 45 publications

References 53 publications

Curcumin in Depression: Potential Mechanisms of Action and Current Evidence—A Narrative Review

Curcumin in Depression: Potential Mechanisms of Action and Current Evidence—A Narrative Review

Evaluation of oxidative stress and psychoemotional status in premature hair graying

Dietary intake of carotenoids and fiber is inversely associated with aggression score in adolescent girls

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