Depression and anxiety symptoms are associated with white blood cell count and red cell distribution width: A sex-stratified analysis in a population-based study

Shafiee, Mojtaba; Tayefi, Maryam; Hassanian, Seyed Mahdi; Ghaneifar, Zahra; Parizadeh, Mohammad Reza; Avan, Amir; Rahmani, Farzad; Khorasanchi, Zahra; Azarpajouh, Mahmoud Reza; Safarian, Hamideh; Moohebati, Mohsen; Heidari‐Bakavoli, Alireza; Esmaeili, Habib; Nematy, Mohsen; Safarian, Mohammad; Ebrahimi, Mahmoud; Ferns, Gordon A.; Mokhber, Naghmeh

doi:10.1016/j.psyneuen.2017.06.021

Cited by 99 publications

(64 citation statements)

References 63 publications

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“…Moreover, an elevated RDW is also observed in non‐hematological diseases that may interfere with red blood cell production because of alteration in overall inflammatory status. Such changes are seen with inflammatory bowel disease, systemic lupus erythematosus, hepatobiliary disease, and Behçet's disease …”

Section: Introductionmentioning

confidence: 99%

“…Such changes are seen with inflammatory bowel disease, 13 systemic lupus erythematosus, 14 hepatobiliary disease, 15 and Behçet's disease. 7,16 There are several studies showing that an increased RDW is related to CVD complications. 17,18 RDW at the upper limit of normal range is associated with a significantly increased risk of CVD and its mortality.…”

Section: Introductionmentioning

confidence: 99%

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The diagnostic and prognostic value of red cell distribution width in cardiovascular disease; current status and prospective

et al. 2019

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The red blood cell distribution width (RDW) is an index of the heterogeneity of circulating red blood cell size, which along with other standard complete blood count (CBC) parameters are used to identify hematological system diseases. Besides hematological disorders, several clinical studies have shown that an increased in the RDW may be associated with other diseases including acute pancreatitis, chronic kidney disease, gastrointestinal disorders, cancer, and of special interest in this review, cardiovascular disease (CVD). The diagnostic and prognostic value of RDW in different CVD (acute coronary syndrome, ischemic cerebrovascular disease, peripheral artery disease, atrial fibrillation, heart failure, and acute ischemic stroke) has been reviewed in this article, to provide an understanding how its measurement may be applied to improve the management of these conditions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The diagnostic and prognostic value of red cell distribution width in cardiovascular disease; current status and prospective

et al. 2019

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“…Depression is a prevalent mental disorder and the second leading cause of global disability, with a high prevalence estimated at 350 million people worldwide [1]. Depression is characterized by a range of symptoms, including a loss of interest in daily activities for more than 2 weeks [1].…”

Section: Introductionmentioning

confidence: 99%

“…Depression is characterized by a range of symptoms, including a loss of interest in daily activities for more than 2 weeks [1]. The outcomes associated with depressive disorders include a negative impact on relationships, families, and work.…”

Section: Introductionmentioning

confidence: 99%

“…The outcomes associated with depressive disorders include a negative impact on relationships, families, and work. It has been estimated that depressive disorders are a significant cause of disease burden in both men and women [1, 2]. Several epidemiological studies have reported that a low serum 25-hydroxy-vitamin D level is a risk factor for depression [3, 4].…”

Section: Introductionmentioning

confidence: 99%

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A High-Protein/Low-Fat Diet May Interact with Vitamin D-Binding Protein Gene Variants to Moderate the Risk of Depression in Apparently Healthy Adults

et al. 2018

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Background: Recent studies have shown that depression is inversely correlated with high protein and low fat intake and positively correlated with vitamin D-binding protein (VDBP). Therefore, the aim of this study was to examine the interaction between protein/fat dietary patterns and VDBP genotypes with regard to the risk of depression in apparently healthy adults who have not been diagnosed with any chronic disease. Methods: In this study, 265 individuals (126 males and 139 females) aged 18–55 years were recruited from the communities of central and west Tehran based on convenience sampling. Body composition was measured with a body composition analyzer and depression symptoms were categorized as normal, moderate depression, or severe depression using the Depression Anxiety Stress Scales 21 (DASS-21) questionnaire. Dietary patterns were determined by a semiquantitative food frequency questionnaire to assess typical food intake during the 12-month period. Blood samples were collected from and biochemical measurements performed on all participants. An analysis of two polymorphisms (rs7041 and rs4588) in the GC gene, which encodes VDBP, was performed by polymerase chain reaction-restriction fragment length polymorphism. Results: A statistically significant association was found between depression and diet (p = 0.03) after having categorized the participants into three groups: a high-protein/low-fat (HP/LF) group, a moderate-protein/moderate-fat (MP/MF) group, and a low-protein/high-fat (LP/HF) group. Moreover, the findings demonstrated that depression was related to both the rs7041 and the rs4588 polymorphism (p = 0.05 and p = 0.02, respectively). We next used multinomial logistic modeling to investigate the risk of depression. A significant interaction was observed between HP/LF diet and the rs7041 polymorphism in the moderate- and severe-depression groups (β = –0.30, p = 0.05, and β = –0.48, p = 0.01, respectively). Conclusion: This study showed that an HP/LF diet interacts with the rs7041 polymorphism, with T allele carriers having a greater prevalence of moderate and severe depression.

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Therapeutic potency of crocin in the treatment of inflammatory diseases: Current status and perspective

Pashirzad

Shafiee

Rezayi

et al. 2019

Journal Cellular Physiology

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Crocin is the major component of saffron, which is used in phytomedicine for the treatment of several diseases including diabetes, fatty liver, depression, menstruation disorders, and, of special interest in this review, inflammatory diseases. Promising selective anti‐inflammatory properties of this pharmacological active component have been observed in several studies. Saffron has been shown to exert anti‐inflammatory properties against several inflammatory diseases and can be used as a novel therapeutic agent for the treatment of inflammatory diseases either alone or in combination with other standard anti‐inflammatory agents. This review summarizes the protective role of saffron and its pharmacologically active constituents in the pathogenesis of inflammatory diseases including digestive diseases, dermatitis, asthma, atherosclerosis, and neurodegenerative diseases for a better understanding and hence a better management of these diseases.

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Depression and anxiety symptoms are associated with white blood cell count and red cell distribution width: A sex-stratified analysis in a population-based study

Abstract: Our results suggest that higher depression and anxiety scores are associated with an enhanced inflammatory state, as assessed by higher hematological inflammatory markers including WBC and RDW, even after adjusting for potential confounders.

Cited by 99 publications

References 63 publications

The diagnostic and prognostic value of red cell distribution width in cardiovascular disease; current status and prospective

The diagnostic and prognostic value of red cell distribution width in cardiovascular disease; current status and prospective

A High-Protein/Low-Fat Diet May Interact with Vitamin D-Binding Protein Gene Variants to Moderate the Risk of Depression in Apparently Healthy Adults

Therapeutic potency of crocin in the treatment of inflammatory diseases: Current status and perspective

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