Depression- and anxiogenic-like behaviors induced by lipopolysaccharide in mice are reversed by a selenium-containing indolyl compound: Behavioral, neurochemical and computational insights involving the serotonergic system

Short- and Long-Term Repeated Forced Swim Stress Induce Depressive-Like Phenotype in Mice: Effectiveness of 3-[(4-Chlorophenyl)Selanyl]-1-Methyl-1H-Indole

“…In the same way, the antidepressant-like effect elicited by CMI has been already shown by our research group. These studies demonstrated the antidepressant-like effect of CMI in the inflammatory model and acute restraint stress model (Casaril et al, 2017(Casaril et al, , 2019a. The persistent investigation of new molecules to depressive symptoms is necessary because the depression precipitated by stress occurs in the general population (Yang et al, 2015).…”

“…Other studies demonstrated that CMI treatment regulates the oxidative stress, for example, acute treatment with CMI reversed oxidative stress in the prefrontal cortices and hippocampi of mice subjected to acute restraint stress (Casaril et al, 2019a); CMI pre-treatment prevented RS production induced by lipopolysaccharide in cerebral cortex of mice (Casaril et al, 2017); Birmann et al (2019) show that CMI also decreased the levels of RS and lipid peroxidation in frontal cortices and hippocampi and plasma levels of corticosterone in mice presenting depressive-like behavior induced by partial sciatic nerve ligation.…”

“…Subsequent studies showed its antidepressant-like propriety in the inflammatory model with the involvement of oxidative stress and reduction of neuroinflammation (Casaril et al, 2017 ) and its antinociceptive effect mediated by the monoaminergic, opioidergic, and adenosinergic systems (Birmann et al, 2018 ). In the previous results, the serotonergic system was suggested as a mechanism of the effect of CMI in the depression—anxiety comorbidity (Casaril et al, 2019b ). More recently, CMI reversed behavioral and biochemical alterations in the dyad pain—depression induced by partial sciatic nerve ligation and possibly modulation of the oxidative system (Birmann et al, 2019 ), and CMI treatment also attenuates depression and cognitive impairment in 4T1 tumor-bearing mice (Maria Casaril et al, 2019 ).…”

Antioxidant Potential of Psychotropic Drugs: From Clinical Evidence to In Vitro and In Vivo Assessment and toward a New Challenge for in Silico Molecular Design

“…The overview thus far gives a quite good picture of how already existing compounds can have tandem beneficial effects in treating major mental disorders and reducing oxidative stress levels. The employment of machine learning algorithms developed in the last few years to the possible use of antipsychotic or antidepressant drugs as effective antioxidants has also seen a decisive contribution of many researchers [ 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 ]. However, many of the studies performed so far made use of statistical or classical mechanics-based methodologies (like QSAR, molecular docking and molecular dynamics) [ 126 , 127 , 128 ].…”

Interactions between the cannabinoid and the serotonergic systems in modulation of pain perception

“…The serotonergic system has been traditionally associated with mood disorders (Casaril et al 2019), motor control (Kawashima 2018), and even potentially life threatening conditions (Koleva and Nikolov 2018). Implication of the serotonergic system in pain control has also been demonstrated.…”