Depression and Cardiovascular Disease: Role of Nitric Oxide

Pinto, Vítor Laerte; Brunini, Tatiana M.C.; Ferraz, Marcos Rochedo; Okinga, Anicet; Mendes-Ribeiro, Antônio Cláudio

doi:10.2174/187152508783955060

Cited by 34 publications

(24 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Higher ADMA levels and pulse wave velocities were shown in CAPD patients with depressive symptoms, which also have been documented in several previous studies in patients with depression who have normal renal function [34,35]. This may suggest that endothelial dysfunction [36] or abnormal nitric oxide biosynthesis [37] in patients with depression might be one potential mechanism underlying the increased prevalence of cardiovascular diseases. …”

Section: Discussionsupporting

confidence: 72%

Association between Depression Symptoms with Inflammation and Cardiovascular Risk Factors in Patients Undergoing Peritoneal Dialysis

Kim

et al. 2010

Nephron Clin Pract

View full text Add to dashboard Cite

Despite medical progress, high morbidity and mortality rates, due primarily to cardiovascular diseases, have persisted in patients with end-stage renal disease (ESRD). Recently, nontraditional risk factors, such as inflammation and malnutrition, have been emphasized in the development or progression of atherosclerosis in ESRD patients. Depression, the most common psychological problem in the ESRD population, is also known to be associated with inflammation and malnutrition, suggesting a possible link between depression with inflammation and cardiovascular diseases. The purpose of this study was to investigate the relationship between depression with cardiovascular risk factors and inflammation in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Eighty-one stable CAPD patients were enrolled. Depressive symptoms were assessed with the Beck Depression Inventory. Various cardiovascular risk factors and inflammatory markers were measured. Forty-three patients had depressive symptoms (53.8%). Patients with depressive symptoms showed significantly lower levels of albumin and IL-10, but higher levels of inflammatory markers than patients without depressive symptoms. Left ventricular hypertrophy was also found more frequently and pulse wave velocity and asymmetric dimethylarginine were all significantly increased in patients with depressive symptoms. Depression in CAPD patients was associated with inflammation and cardiovascular risk factors, and might be used as a predictor of cardiovascular diseases.

show abstract

Section: Discussionsupporting

confidence: 72%

Association between Depression Symptoms with Inflammation and Cardiovascular Risk Factors in Patients Undergoing Peritoneal Dialysis

Kim

et al. 2010

Nephron Clin Pract

View full text Add to dashboard Cite

show abstract

“…Cognitive findings Z<-2 SD: patients who had average results in at least one cognitive domain of less than two standard deviations (SD) depression (Pinto et al 2008). We suggest that nitric oxide pathway abnormalities could be related to the neuropsychiatric findings in Fabry patients.…”

Section: Discussionmentioning

confidence: 80%

Psychiatric and cognitive profile in Anderson‐Fabry patients: a preliminary study

Segal¹,

Kohn

Pollak

et al. 2010

J of Inher Metab Disea

View full text Add to dashboard Cite

Anderson-Fabry disease (AFD) is an X-linked inherited lysosomal storage disorder disease caused by a deficiency in the activity of the alpha-galactosidase enzyme. We investigated neuropsychological and psychiatric function in AFD patients. We studied 16 AFD patients, aged 7 to 61 years. Intelligence, language, vision-spatial abilities, memory, sensorimotor abilities, and attention and executive functions were tested with a computerized test battery as well as standard paper and pencil tests. The results were compared to known age-based norms. In addition, all patients were screened for lifelong DSM-IV Axis-I and Axis-II psychiatric diagnoses, and 4 were interviewed by a psychiatrist. Performance on most cognitive measures was within average range. All measures of information processing speed were significantly reduced, as were some measures of executive functions. Ten out of 16 patients met DSM-IV criteria for Axis I or Axis II diagnoses at some point in their lives. This preliminary study delineates a psychiatric and cognitive phenotype in AFD patients and contributes to the growing field of characterizing behavioral phenotypes of patients with genetic diseases. We suggest that psychiatric and neuro-psychological evaluation be included in the patient's evaluation.

show abstract

“…In depressive patients, the L-argininenitric oxide pathway seems to be impaired. Further clinical studies are needed to confirm the beneficial effects of Larginine uptake on amelioration of symptoms in patients with CAD and depression [54].…”

Section: Role Of No In Endothelial Disfunctionmentioning

confidence: 99%

Nitric Oxide and its Role in Cardiovascular Diseases

Dobutović¹

2011

TONOJ

View full text Add to dashboard Cite

Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation. NO is a free radical which reacts with various molecules to cause multiple biological effects. It is clear that the generation and actions of NO under physiological and pathophysiological conditions are exquisitely regulated and extend to almost every cell type and function within the circulation. While the molecule mediates many physiological functions, an excessive presence of NO is toxic to cells. The enzyme NOS, constitutively or inductively, catalyses the production of NO in several biological systems. NO is derived not only from NOS isoforms but also from NOS-independent sources. In mammals, to date, three distinct NOS isoforms have been identified: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). The molecular structure, enzymology and pharmacology of these enzymes have been well defined, and reveal critical roles for the NOS system in a variety of important physiological processes. This review focuses on recent advances in the understanding of the interactions between NOS enzymes and pathophysiology of cardiovascular diseases (CVD) and the role of NO agonists as potential therapeutic agents in treatment of CVD.

show abstract

Depression and Cardiovascular Disease: Role of Nitric Oxide

Cited by 34 publications

References 62 publications

Association between Depression Symptoms with Inflammation and Cardiovascular Risk Factors in Patients Undergoing Peritoneal Dialysis

Association between Depression Symptoms with Inflammation and Cardiovascular Risk Factors in Patients Undergoing Peritoneal Dialysis

Psychiatric and cognitive profile in Anderson‐Fabry patients: a preliminary study

Nitric Oxide and its Role in Cardiovascular Diseases

Contact Info

Product

Resources

About