Depression and Ischemic Heart Disease or Ischemic Heart Disease and Depression?

Abstract

This editorial highlights how difficult is the correlation between Mood Disorder and Ischemic Heart Disease. In particular, it highlights the serious problem of suicide risk. This long-standing problem, object of controversy in the scientific literature, requires insights that should avoid simple surveys entrusted to the questionnaires, and the subjectivity of the clinical judgment. The text of the Editorial suggests the opportunity for substantial insights in the study of biological markers that give greater certainty of psychiatric diagnosis. The effort of the authors, in this sense, has proved highly effective in recognizing some of the major psychiatric disorders (Major Depression, Bipolar Disorder, Obsessive Compulsive Disorder and suicidal thoughts). Much work, however, remains to be done. The further suggestion which can be obtained from the script is that the complexity of mental phenomena must be faced with complex mathematical tools, to find diagnostic certainty and not diagnosis of opinion.

Ongoing Brain Activity and Its Role in Cognition: Dual versus Baseline Models

“…Are the task-related temporal receptive windows shaped by the topographical organization of the intrinsic neural timescales in the resting state? Conducting a modeling study with a synchronization (Kuramoto) model and simulation of transcranial magnetic stimulation (TMS), Gollo and others (2017) demonstrate that regions with longer ACW, as located in DMN and central executive network, show lower and more sluggish activity changes in response to external stimuli than sensory regions with their shorter ACW that exhibit higher amplitude and faster response to external stimuli (see also Cocchi and others 2016; Kiebel and others 2008). Analogous results were observed in the modeling study by Chaudhuri and others (2015), who applied electrical stimulation to V1 in visual cortex (see also Demirtaş and others 2019).…”