Depression and long-term prognostic outcomes following peripheral endovascular interventions in the VA Healthcare System

Smolderen, Kim G.; Plomondon, Mary E.; Armstrong, Ehrin J.; Hess, Edward; Waldo, Stephen W.; Tsai, Thomas T.; Maddox, Thomas M.

doi:10.1177/1358863x18770275

Cited by 12 publications

(5 citation statements)

References 21 publications

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“…In addition, the occurrence of ISR not only makes the patient feel physical pain but also increases the negative psychological mood and reduces happiness. Depression is a common negative psychological mood in patients with arterial disease 14 . Resting pain leads to poor sleep at night, causing anxiety, fear, and other bad emotions 15 .…”

Section: Discussionmentioning

confidence: 99%

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Quality of life for patients with in-stent restenosis after interventional therapy of peripheral artery disease

Zhu,

Xu,

Liu

et al. 2023

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: The aim of this study was to investigate the quality of life for patients with in-stent restenosis after interventional therapy of peripheral artery disease and the influencing factors. METHODS: A total of 72 in-stent restenosis patients after interventional therapy of peripheral artery disease were enrolled, whose general data were obtained. SF-12 scale was used to evaluate the quality of life. Tilburg Frailty Scale was used to assess senile debilitation. Pittsburgh Quality Index Scale was used to evaluate sleep quality. Activity of Daily Living Scale was used to evaluate the self-care ability. The general data and in-stent restenosis-related indicators were compared between patients with low and high quality of life, respectively. Multivariate regression analysis was made on the factors affecting quality of life. RESULTS: The average total quality of life score of 72 patients was 74.06±19.26 points. The gender, Fontaine stage and smoking, Activity of Daily Living Scale score, painless walking distance, senile debilitation score, sleep quality score, white blood cells, and C-reactive protein had significant differences between the two groups, respectively (p<0.05). Multivariate regression analysis showed that the female gender, low Fontaine stage (OR=0.186), low senile debilitation score (OR=0.492), and high sleep quality score (OR=0.633) were the protective factors for high quality of life (all p<0.05), and the low Activity of Daily Living score (OR=1.282) was the risk factor for high quality of life (p<0.05). CONCLUSION: Quality of life of in-stent restenosis patients after interventional therapy of peripheral artery disease is low. Gender, Fontaine stage, senile debilitation, sleep quality, and Activity of Daily Living score are the influencing factors of quality of life for in-stent restenosis patients.

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Section: Discussionmentioning

confidence: 99%

“…The questionnaire with SF-12 scale showed that the lowest, highest, and average PCS scores of 72 ISR patients were 20.24, 54.84, and 35.97±10 14. points, respectively, and the lowest, highest, and average MCS scores were 19.37, 59.78, and 38.09±10.53 points, respectively.…”

mentioning

confidence: 97%

Quality of life for patients with in-stent restenosis after interventional therapy of peripheral artery disease

Zhu,

Xu,

Liu

et al. 2023

Rev. Assoc. Med. Bras.

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“…24 Looking at the same VA population but focusing only on patients undergoing catheter-based peripheral vascular intervention, Smolderen et al found that the incidence of depression was almost same as ours, around 33%. 11 In our cohort we also included patients undergoing bypass operation, and this constituted about 32% of the total population, which is significant given that this patient population usually has a higher disease burden and is more functionally impaired.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5] Surgical intervention is indicated for patients with life-limiting short distance claudication after failure of medical management, rest pain, and/or tissue loss. 3 In previous publications, depression has been identified as a significant risk factor for development of PAD, also affecting the functional performance on this population, 6,7 and is associated with worse outcomes after intervention [8][9][10][11][12] ;however, these studies were conducted on patients from the Veterans Affairs (VA) system which is not representative of the population on a "real world" vascular practice.…”

Section: Introductionmentioning

confidence: 99%

Preoperative Depression is Associated with Worse Outcomes after The Lower Extremity Revascularization

et al. 2022

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Objective This retrospective study sought to describe the association between preoperative diagnosis of depression and major adverse events after infrainguinal bypass surgery or peripheral vascular intervention (PVI). Methods We retrospectively analyzed a consecutive series of all patients undergoing PVI and/or infrainguinal bypass surgery at a single tertiary institution between 2010 and 2019. Propensity matching and Cox regression analysis were conducted to examine the impact of comorbid depression on the incidence of major adverse events (MAEs), defined as re-intervention, major amputation, or death, within 2 years of surgery. Results Of all patients ( n = 512) undergoing intervention at our institution, 166 (32.4%) suffered an MAE and 169 (33.0%) patients had a preoperative diagnosis of depression. After propensity score matching, univariate (HR, 1.7; 95% CI, 1.1–2.7) and multivariable hazard analyses (aHR, 1.50; [1.1–2.2]) demonstrate that there is a statistically significant relationship between the diagnosis of depression and increased MAE. Conclusion Over one-third of our lower extremity revascularization patients were noted to have a preoperative diagnosis of depression. After intervention, these patients had worse outcomes compared to patients without depression; this finding was more evident in patients who underwent PVI mainly due to high overall mortality rate. Prospective studies are necessary to better understand this association and to ascertain if early intervention can improve post-procedure vascular outcomes.

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“…Treatment for PAD emphasize improving quality of life and decreasing the risk of new cardiovascular disease events, mainly through pharmacotherapy and revascularization procedures [11] . Recently in a study of 797 consecutive patients undergoing peripheral vascular intervention across 33 Veterans Affairs centers, depressed patients had higher rates of non-fatal cardiovascular events compared to patients without depression [12] . In addition to increasing the risk of PAD, depression also appears to impact the functional status and symptoms of patients with PAD.…”

Section: Discussionmentioning

confidence: 99%

Risk factors of depression in type 2 diabetes mellitus with lower extremity arterial disease in China

Chai

Zhang

Yuan

et al. 2020

Preprint

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BackgroundWe aimed to evaluate the prevalence and risk factors of depression in type 2 diabetes mellitus with lower extremity arterial disease. Methods: Four hundred and forty-one patients with type 2 diabetes mellitus were recruited from Peking University of International Hospital. All patients completed the Self-rating Depression Scale, which includes 20 items, using a 4-point scale. Univariable and multivariable logistic regression was conducted to investigate risk factors of depression in patients with lower extremity arterial disease. Results: The prevalence of depression in lower extremity arterial disease group was significantly higher than that in non- lower extremity arterial disease group(25% vs 16%, P = 0.018). In lower extremity arterial disease group(n = 215), depression score(46.18 ± 7.38 vs 44.03 ± 6.53, P = 0.003) significantly increased compared with non lower extremity arterial disease group(n = 226). Compared with male depressive patients, the proportion of female depressive patients(38% vs 15%, P = 0.003) was significantly higher in lower extremity arterial disease group. The depression score of female depressive patients(57.83 ± 3.29 vs 55.26 ± 1.59, P = 0.003) was significantly higher than that of male depressive patients. An increased risk of depression in female patients(crude OR: 2.50, 95% CI: 1.38–4.54, P = 0.003; adjusted OR: 2.34, 95% CI: 1.26–4.36, P = 0.008) and in patients with low body mass index(crude OR: 0.88, 95% CI: 0.80–0.96, P = 0.005; adjusted OR: 0.89, 95% CI: 0.81–0.97, P = 0.011) was detected. Conclusion: Both low body mass index and female are risk factors for depression.

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Depression and long-term prognostic outcomes following peripheral endovascular interventions in the VA Healthcare System

Cited by 12 publications

References 21 publications

Quality of life for patients with in-stent restenosis after interventional therapy of peripheral artery disease

Quality of life for patients with in-stent restenosis after interventional therapy of peripheral artery disease

Preoperative Depression is Associated with Worse Outcomes after The Lower Extremity Revascularization

Risk factors of depression in type 2 diabetes mellitus with lower extremity arterial disease in China

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