2020
DOI: 10.1017/s0033291720003037
|View full text |Cite
|
Sign up to set email alerts
|

Depression and memory function – evidence from cross-lagged panel models with unit fixed effects in ELSA and HRS

Abstract: Background Individuals with depression are often found to perform worse on cognitive tests and to have an increased risk of dementia. The causes and the direction of these associations are however not well understood. We looked at two specific hypotheses, the aetiological risk factor hypothesis and the reverse causality hypothesis. Method We analysed observational data from two cohorts, English Longitudinal Study of Ageing (ELSA) and Health and Retirement Study (HRS), using cross-lagged … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
2
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 6 publications
(2 citation statements)
references
References 47 publications
0
2
0
Order By: Relevance
“…High depression levels in older adults during COVID-19 7 , may lead to side-effects 8 ; likewise, side-effects may lead to depression 8 . Future studies measuring these variables across time points may enable discerning causality provided suitable models are applied 9 . Experimental studies may also be revealing, e.g., comparing vaccination side-effects in a group of older adults whose depression rate was experimentally lowered (e.g., via an intervention) to a control group.…”
mentioning
confidence: 99%
“…High depression levels in older adults during COVID-19 7 , may lead to side-effects 8 ; likewise, side-effects may lead to depression 8 . Future studies measuring these variables across time points may enable discerning causality provided suitable models are applied 9 . Experimental studies may also be revealing, e.g., comparing vaccination side-effects in a group of older adults whose depression rate was experimentally lowered (e.g., via an intervention) to a control group.…”
mentioning
confidence: 99%
“…In pre‐frailty, RCF and PRCF in older adults are closely associated with depression and energy level, indicating that mental health constitutes a risk factor for CF. Research demonstrates that current depression predicts future cognitive decline, 43 as depression and cognition share common biological mechanisms such as hippocampal atrophy and nerve growth factor deficiency 44 . Depression can disrupt neural connections and damage cognitive function by elevating inflammatory cytokines and cortisol 44,45 .…”
Section: Discussionmentioning
confidence: 99%