Depression and Mortality

Rovner, Barry W.; German, Pearl S.; Brant, Larry J.; Clark, Rebecca; Burton, Lynda; Folstein, Marshal F.

doi:10.1001/jama.1991.03460080063033

Cited by 306 publications

(26 citation statements)

References 31 publications

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“…(16, 49, 51, 52, 56, 59) In comparison to community dwelling older adults, nursing home residents have a higher rate of falling(51, 67) and mood disorders. (68, 69)…”

Section: Resultsmentioning

confidence: 99%

Cause or Effect? Selective Serotonin Reuptake Inhibitors and Falls in Older Adults: A Systematic Review

Gebara

Lipsey

Karp

et al. 2015

The American Journal of Geriatric Psychiatry

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A 2012 update of the Beers criteria categorizes selective serotonin reuptake inhibitors (SSRIs) as potentially inappropriate medications in all older adults based on fall risk. The application of these recommendations, not only to frail nursing home residents, but also to all older adults, may lead to changes in health policy or clinical practice with harmful consequences. A systematic review of studies on the association between SSRIs and falls in older adults was conducted to examine the evidence for causation. Twenty-six studies met the inclusion criteria. The majority of studies were observational and suggest an association between SSRIs and falls. The direction of the relationship – causation or effect- cannot be discerned from this type of study. Standardized techniques for determining likely causation were then used to see if there was support for the hypothesis that SSRI’s lead to falls. This analysis did not suggest causation was likely. There is no Level 1 evidence that SSRIs cause falls. Therefore, changes in the current treatment guidelines or policies on the use of SSRIs in older adults based on fall risk may not be justified at this time given the lack of an established evidence base. Given its significance to public health, well-designed experimental studies are required to address this question definitively.

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“…(16, 49, 51, 52, 56, 59) In comparison to community dwelling older adults, nursing home residents have a higher rate of falling(51, 67) and mood disorders. (68, 69)…”

Section: Resultsmentioning

confidence: 99%

Cause or Effect? Selective Serotonin Reuptake Inhibitors and Falls in Older Adults: A Systematic Review

Gebara

Lipsey

Karp

et al. 2015

The American Journal of Geriatric Psychiatry

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“…Over the course of this 4-year experiment, 56% of the monkeys in the highest quartile of depression died (5/9), whereas there was only one (11%) or two (22%) deaths in each of the other quartiles. Depression is also associated with non suicide mortality in the human population (Bradvik and Berglund, 2001; Kouzis et al, 1995; Rovner et al, 1991; von Ammon Cavanaugh et al, 2001). …”

Section: Direct Comparisons Between Social Subordination Stress and Dmentioning

confidence: 99%

Behavioral and neurobiological characteristics of social stress versus depression in nonhuman primates

Shively¹,

Willard²

2012

Experimental Neurology

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The focus of the review is on the behavioral and physiological manifestations of stress versus depression. The purpose of the review is to evaluate the conceptual approach of using stress models as surrogates for depression. Social stress and depression have many characteristics in common and promote each other. Both have adverse effects on social relationships and the quality of life, and increase risk of other diseases. However, they are not the same constructs. In human and nonhuman primates, the behavior and neurobiology of stressed individuals differ from that of depressed individuals. Some similarities in stress physiology in socially stressed and depressed individuals have been used to support the use of stressed animals as models of depression, and much has been learned from stress models of depression. However, the studies reviewed here also suggest that the depressed state also has different characteristics than the stressed state, and studying the differences may be important to furthering our understanding of each of these constructs as well as their mutual relationship.

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“…Some authors have reported that the predictors of persistent headaches include the presence of major depression,79 while others have reported that depression did not predict the persistence of CDH 28. Depression is associated with increased personal suffering, mortality (suicide is the most common cause of death in patients with major depression), utilization of healthcare services, decreased functioning, and reduced quality of life 123–125. Other studies report that levels of emotional functioning and perception of stress, independent of the level of pain at baseline, were predictive of frequency, intensity, and duration of headaches 83,126.…”

Section: Prognosismentioning

confidence: 99%

Psychiatric comorbidity and suicide risk in patients with chronic migraine

Pompili¹,

Serafini²,

Cosimo³

et al. 2010

NDT

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The aim of this study was to explore the impact of mental illness among patients with migraine. We performed MedLine and PsycINFO searches from 1980 to 2008. Research has systematically documented a strong bidirectional association between migraine and psychiatric disorders. The relationship between migraine and psychopathology has often been clinically discussed rather than systematically studied. Future research should include sound methodologically-based studies focusing on the interplay of factors behind the relationship between migraine, suicide risk, and mental illness.

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Depression and Mortality

Cited by 306 publications

References 31 publications

Cause or Effect? Selective Serotonin Reuptake Inhibitors and Falls in Older Adults: A Systematic Review

Cause or Effect? Selective Serotonin Reuptake Inhibitors and Falls in Older Adults: A Systematic Review

Behavioral and neurobiological characteristics of social stress versus depression in nonhuman primates

Psychiatric comorbidity and suicide risk in patients with chronic migraine

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