Depression and Other Mental Health Diagnoses Increase Mortality Risk After Ischemic Stroke

Williams, Linda S.; Ghose, Sushmita Shoma; Swindle, Ralph

doi:10.1176/appi.ajp.161.6.1090

Cited by 272 publications

(198 citation statements)

References 43 publications

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“…PSD is associated with worse functional outcomes, quality of life, and increased post-stroke mortality. [6][7][8][9] Our prior work has demonstrated that these effects are present in veterans with PSD, as we found that those with a new depression diagnosis post-stroke had a 25% increase in mortality 9 and health care utilization 10 post-stroke.…”

Section: Introductionsupporting

confidence: 50%

Pre-post Evaluation of Automated Reminders May Improve Detection and Management of Post-stroke Depression

Williams

Ofner

et al. 2011

J GEN INTERN MED

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Section: Introductionsupporting

confidence: 50%

Pre-post Evaluation of Automated Reminders May Improve Detection and Management of Post-stroke Depression

Williams

Ofner

et al. 2011

J GEN INTERN MED

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“…Poststroke depression (PSD) has been recognized as a common sequela of stroke, with an increased morbidity and mortality (Williams, Ghose, & Swindle, 2004). PSD are approximately 85% of patients with strokes (Robinson & Jorge, 2016), and are associated with more serious functional dysfunction (Cully et al., 2005), delayed rehabilitation outcomes (Gillen, Tennen, McKee, Gernert‐Dott, & Affleck, 2001), as well as social withdrawal after stroke (Feibel & Springer, 1982; Robinson, Starr, Kubos, & Price, 1983).…”

Section: Introductionmentioning

confidence: 99%

The association between lesion location, sex and poststroke depression: Meta‐analysis

et al. 2017

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BackgroundPoststroke depression (PSD) is a common form of stroke patients. Whether the risk of PSD is influenced by the stroke lesion location and sex remains a matter of debate. The objective of this study was to examine the association between the risk of PSD and the stroke lesion location and sex by performing a systematic meta‐analysis.MethodsSubgroup analyses were performed according to the time interval after stroke onset to assessment for PSD. A total of 31 reports involving 5,309 subjects (for lesion location analysis) and 5,489 subjects (for sex analysis) suffering from stroke were included in this meta‐analysis.ResultsThe pooled odds ratio (OR) of PSD after a left‐hemisphere stroke, compared with a right‐hemisphere stroke was 1.11 (95% confidence interval [CI] 0.82–1.49) and OR of PSD after a male stroke, compared with a female stroke was 0.68 (95% CI 0.58–0.81). Subacute poststroke subgroup (1–6 months) significantly favored PSD occurring after a left hemisphere stroke (OR = 1.50, 95% CI 1.21–1.87). Furthermore, there was a statistically significant association between PSD and female stroke for studies with acute poststroke group (OR = 0.73, 95% CI 0.62–0.86) and subacute poststroke stroke phase (OR = 0.69, 95% CI 0.56–0.86).ConclusionsThis systematic review suggests that patients with left hemisphere stroke may be more susceptible to PSD during subacute phase of stroke and female stroke may be more susceptible to PSD during acute and subacute phase of stroke.

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“…Depression is a common complication after stroke and is associated with increased mortality [1], poor functional outcome [2], and decreased quality of life [3]. Over the past 20 years conflicting findings have been reported regarding the association between cognitive impairment and depressive pathology after stroke.…”

Section: Introductionmentioning

confidence: 99%

Early cognitive impairment predicts long-term depressive symptoms and quality of life after stroke

Nys¹,

Zandvoort²,

Worp³

et al. 2006

Journal of the Neurological Sciences

263

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Objective: The aim of the present study was to examine the predictive value of cognitive impairment in the acute phase after stroke as a risk factor for long-term (six to ten months after stroke) depressive symptoms (DS) and a reduced quality of life (QOL), independent of demographic and neurological predictors. Methods: We evaluated 143 patients within the first 3 weeks post-stroke. Predictor variables included domain-specific cognitive function, demographic data, vascular risk factors, lesion characteristics, and clinical factors. Predictor variables associated with long-term DS (Montgomery Å sberg Depression Rating Scale ! 7) and QOL (Stroke-Specific Quality of Life Scale) were identified with multiple logistic and linear regression. Results: Long-term DS were independently predicted by cognitive impairment at baseline, DS at baseline, female sex, diabetes mellitus, and previous TIA(s). Cognitive impairment, increasing age, and functional dependence predicted a reduced QOL, whereas hypercholesterolaemia predicted a better QOL. Among all cognitive disorders, unilateral neglect was the greatest risk factor for DS after 6 months, whereas a disorder in visual perception and construction affected QOL the most. Conclusions: Cognitive impairment and vascular risk factors are important predictors of long-term DS and QOL after stroke. The prognostic value of cognition suggests a reactive component in the development or continuation of long-term DS. D

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Depression and Other Mental Health Diagnoses Increase Mortality Risk After Ischemic Stroke

Cited by 272 publications

References 43 publications

Pre-post Evaluation of Automated Reminders May Improve Detection and Management of Post-stroke Depression

Pre-post Evaluation of Automated Reminders May Improve Detection and Management of Post-stroke Depression

The association between lesion location, sex and poststroke depression: Meta‐analysis

Early cognitive impairment predicts long-term depressive symptoms and quality of life after stroke

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