Depression and parkinson's disease: a new look at an old problem

Edwards, Emmeline; Kitt, Cheryl A.; Oliver, Eugene; Finkelstein, James D.; Wagster, Molly V.; McDonald, William M.

doi:10.1002/da.10057

Cited by 33 publications

(28 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Unfortunately, however, only 20% of all depressed PD patients receive treatment for their depression [3]. If depression is left untreated, there is an increased risk for greater disability and reduced quality of life for this PD population [4]. A better understanding of the etiology of depression in PD may lead to the selection of more effective treatments.…”

Section: Introductionmentioning

confidence: 99%

The neuropathological basis for depression in Parkinson's disease

Frisina

Haroutunian

Libow

2009

Parkinsonism & Related Disorders

128

View full text Add to dashboard Cite

Depression is found in 30-40% of all patients with Parkinson's disease (PD), but its etiology is unclear. Using neuropathology as a signpost for neurotransmitter function, we investigated the prevalence of pathological features found at postmortem and sought to uncover differences between depressed (n = 11) and non-depressed (n = 9) elderly PD patients. The results indicate a higher prevalence of pathological features in depressed compared to non-depressed PD patients, particularly in catecholamine areas of the brain; the locus coeruleus (neuronal loss: odds ratio = 7.2, p = 08; gliosis: odds ratio = 18.0, p = 008); dorsal vagus nerve (gliosis: odds ratio = 7.63, p < 0.05), and substantia nigra pars compacta (gliosis: odds ratio 2.85, ns). However, neuropathological differences were absent in the dorsal raphe nuclei, amygdala, and cortical regions. Our evidence suggests that depression in PD is related more to catecholaminergic than serotonergic system dysfunction.

show abstract

Section: Introductionmentioning

confidence: 99%

The neuropathological basis for depression in Parkinson's disease

Frisina

Haroutunian

Libow

2009

Parkinsonism & Related Disorders

128

View full text Add to dashboard Cite

show abstract

“…The mean age of developing the disease is 58 years, and PD affects men more frequently than women /1.6:1/ (Edwards, et al, 2002, Nelson, 2002. The main cause of PD is the degeneration of dopaminergic neurons of substantia nigra in the nigro-striatal system of the brain.…”

Section: Late -Onset Hypogonadism and Parkinson's Diseasementioning

confidence: 99%

“…Yet numerous symptoms resulting from the deficiency of such sex hormones as testosterone in men and progesterone-estrogen group in women, may co-exist with motor and other PD symptoms. These include impotence, lowered joy of life, lack of energy and mental depression (Edwards, et al, 2002, Nelson, 2002. Experimental studies have shown that estrogens can protect hippocampus neurons against beta-amyloid protein, which is implicated in the development of PD.…”

Section: Late -Onset Hypogonadism and Parkinson's Diseasementioning

confidence: 99%

Late - Onset Hypogonadism - New Point of View

Gomuła¹

2012

Sex Hormones

View full text Add to dashboard Cite

“…A doença de Parkinson (DP) é uma doença progressiva e crônica do sistema nervoso, envolvendo os gânglios da base e resultando em perturbações no tônus muscular, posturas anormais e movimentos involuntários 1 . Pode ser considerada a segunda doença neurodegenerativa senil mais comum, acometendo cerca de 1% a 2% da população acima dos 65 anos de idade 2 .…”

Section: Introductionunclassified

Prevalência de depressão na doença de Parkinson

Nakabayashi¹,

Chagas²,

Corrêa³

et al. 2008

Rev. psiquiatr. clín.

View full text Add to dashboard Cite

ResumoContexto: O reconhecimento da prevalência da depressão em pacientes com doença de Parkinson (DP) é necessá-rio para o desenvolvimento de práticas direcionadas ao tratamento da depressão e a melhora na qualidade de vida deles. Objetivo: Identificar na literatura indexada estudos relacionados à prevalência de depressão na DP, visto que normalmente há sub-reconhecimento e subdiagnóstico da comorbidade. Métodos: Levantamento de artigos no PubMed, LILACS e SciELO que cumpriram com as palavras-chave: prevalence, depression e Parkinson. Critérios para inclusão: artigos nos idiomas inglês, português e espanhol, sem limite de tempo. Excluíram-se artigos relacionados ao tratamento da DP e validação de escalas. Resultados: Selecionaram-se 20 artigos com taxas de prevalência de depressão de 1,8% a 68,1%. Seis estudos foram casos-controle, dois foram coortes, um, longitudinal prospectivo e 13, transversais. Quanto à técnica de avaliação, oito empregaram entrevista clínica, nove utilizaram apenas instrumentos de auto-avaliação, um empregou entrevista clínica e instrumentos de auto-avaliação e quatro consultaram bancos de dados. Conclusões: A prevalência de depressão variou de acordo com a metodologia, porém, em geral, as taxas foram bastante elevadas. Evidenciou-se a necessidade de definições mais precisas sobre depressão na DP para se estabelecer uma taxa de prevalência mais acurada.Nakabayashi TIK, et al. / Rev Psiq Clín. 2008;35(6):219-27 Palavras-chave: Prevalência, depressão, Parkinson. AbstractBackground: The recognition of depression prevalence in Parkinson's disease (PD) is necessary for the development of treatment techniques as well as the improvement in the patient's quality of life. Objective: To identify in the literature studies related to the prevalence of depression in PD. Methods: The search for articles was based on PubMed, LILACS and SciELO matching the key-words prevalence, depression and Parkinson. Inclusion criteria of articles were: papers in English, Portuguese and Spanish; without time limitation. Articles related to the treatment of PD and to the validation of scales were excluded. Results: A total of 20 studies were selected, including six casecontrol studies, 3 longitudinal (2 cohort) studies, and 43 non-sectional studies. Prevalence rates ranged from 1.8% to 68.1%. Concerning the evaluation of techniques employed, eight studies used clinical interviews, nine used just self-report instruments, one utilized clinical interviews and self-report instruments and four consulted data bases. Discussion: The prevalence of depression varied according to the methodology, however, in general, rates proved

show abstract

Depression and parkinson's disease: a new look at an old problem

Cited by 33 publications

References 39 publications

The neuropathological basis for depression in Parkinson's disease

The neuropathological basis for depression in Parkinson's disease

Late - Onset Hypogonadism - New Point of View

Prevalência de depressão na doença de Parkinson

Contact Info

Product

Resources

About