Depression and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients

Grassi, Luigi; Rossi, Elena; Cobianchi, Marina; Aguiari, Letizia; Capozzo, Marianna; Martinis, Elisabetta; Nanni, Maria Giulia; Lelli, G.; Schillani, Giulia; Biancosino, Bruno; Giraldi, Tullio

doi:10.1016/j.jad.2009.12.022

Cited by 17 publications

(22 citation statements)

References 30 publications

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“…We found in a previous study that the serotonin transport polymorphism HTTLPR was associated with nausea experienced by women up to a month following breast cancer surgery (Wesmiller et al, 2014). Those results were not replicated in this study; consistent with other researchers that have reported conflicting results with HTTLPR (Aapro et al, 2012; Grassi et al, 2010; Schillani et al, 2012). The DRD2 Taq1A polymorphism was not significant for association in this study.…”

Section: Discussionsupporting

confidence: 74%

Exploring the multifactorial nature of postoperative nausea and vomiting in women following surgery for breast cancer

Wesmiller

Sereika

Bender

et al. 2017

Autonomic Neuroscience

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Background Postoperative nausea and vomiting (PONV) are two of the most frequent and distressing complications following surgical procedures, with as many as 80% of patients considered to be at risk. Despite recognition of well-established risk factors and the subsequent use of clinical guidelines, 20–30% of women do not respond to antiemetic protocols, indicating that there may be a genetic risk. Objective The purpose of this pilot study was to describe the incidence and explore the risk factors associated with PONV after surgery in women diagnosed with early stage breast cancer. Methods A prospective cohort design was employed to measure PONV in women recruited prior to surgery. DNA was extracted from saliva samples collected prior to discharge. Polymorphisms for seven candidate genes with a known role in one of the neural pathways associated with PONV were included in this study; serotonin receptor (HTR3A), serotonin transport (SLC6A4), tryptophan (TPH), dopamine receptors (DRD2/ANKK and DRD3), catechol-O-methyltransferase (COMT) and histamine (H1). Results Twenty-nine (29.8%) women experienced nausea and 10 (11%) experienced nausea and vomiting while in the PACU despite administration of multiple antiemetic medications. Women who experienced PONV had higher levels of pain and received more opioids than those women who did not experienced PONV. Odds ratios demonstrated that alleles for the COMT, DRD3, and TPH genes were associated with decreased PONV. Conclusion The understanding of the multifactorial nature of PONV and the recognition of genetic risk will ultimately lead to the development of personalized interventions to manage these frequent and often debilitating symptoms.

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Section: Discussionsupporting

confidence: 74%

Exploring the multifactorial nature of postoperative nausea and vomiting in women following surgery for breast cancer

Wesmiller

Sereika

Bender

et al. 2017

Autonomic Neuroscience

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“…The 5-HTTLPR s allele is associated with depression in head-and-neck cancer patients 57 but not in breast cancer patients. 58 Findings from our research group 59 support the latter study, which reported no associations of the 5-HTTLPR and 5-HTR2a genes with depressive disorder in Korean breast cancer patients. In terms of BDNF, data from a 1-year longitudinal study demonstrated that the met/met genotype was associated with depression 1 week after mastectomy and with persistent depression 1 year after mastectomy.…”

Section: Risk Factors For Depression In Patients With Physical Disordsupporting

confidence: 73%

Comorbidity of Depression with Physical Disorders: Research and Clinical Implications

et al. 2015

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Depression is prevalent in patients with physical disorders, particularly in those with severe disorders such as cancer, stroke, and acute coronary syndrome. Depression has an adverse impact on the courses of these diseases that includes poor quality of life, more functional impairments, and a higher mortality rate. Patients with physical disorders are at higher risk of depression. This is particularly true for patients with genetic and epigenetic predictors, environmental vulnerabilities such as past depression, higher disability, and stressful life events. Such patients should be monitored closely. To appropriately manage depression in these patients, comprehensive and integrative care that includes antidepressant treatment (with considerations for adverse effects and drug interactions), treatment of the physical disorder, and collaborative care that consists of disease education, cognitive reframing, and modification of coping style should be provided. The objective of the present review was to present and summarize the prevalence, risk factors, clinical correlates, current pathophysiological aspects including genetics, and treatments for depression comorbid with physical disorders. In particular, we tried to focus on severe physical disorders with high mortality rates, such as cancer, stroke, and acute coronary syndrome, which are highly comorbid with depression. This review will enhance our current understanding of the association between depression and serious medical conditions, which will allow clinicians to develop more advanced and personalized treatment options for these patients in routine clinical practice.

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“…A further biological factor to be mentioned regards the role of the polymorphism of the serotonin transporter-linked region (5-HTTLPR) that in psychiatry has been suggested to predict the development of depression after stress [60]. No specific support was found on this association, alone or in conjunction with life events, in the few existing studies relative to head and neck cancer [61], breast cancer [62,63] and colon cancer patients, including a recent meta-analysis [64].…”

Section: Risk Factors For Depressive Spectrum Disorders In Cancermentioning

confidence: 99%

Depressive spectrum disorders in cancer: prevalence, risk factors and screening for depression: a critical review

et al. 2017

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Depression and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients

Cited by 17 publications

References 30 publications

Exploring the multifactorial nature of postoperative nausea and vomiting in women following surgery for breast cancer

Exploring the multifactorial nature of postoperative nausea and vomiting in women following surgery for breast cancer

Comorbidity of Depression with Physical Disorders: Research and Clinical Implications

Depressive spectrum disorders in cancer: prevalence, risk factors and screening for depression: a critical review

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