Depression and substance use disorders: Clinical comorbidity and shared neurobiology

Calarco, Cali A.; Lobo, Mary Kay

doi:10.1016/bs.irn.2020.09.004

Cited by 33 publications

(21 citation statements)

References 241 publications

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“…A wealth of literature has sought to uncover how stress drives increased susceptibility to substance use, and the neurobiological underpinnings of comorbid stress and substance use disorders [For recent reviews see: Newman et al (2018) and Calarco and Lobo (2020) ]. Psychosocial stress is of particular interest as it is thought to more closely mimic human stressors.…”

Section: Introductionmentioning

confidence: 99%

“…Numerous brain regions are sensitive to both drugs and stress, including the nucleus accumbens (NAc) ( Hollon et al, 2015 ; Newman et al, 2018 ; Calarco and Lobo, 2020 ). Indeed, both chronic stress and opioid exposure cause structural changes in the NAc that are thought to drive stress-susceptibility or increased drug intake ( Matsubara et al, 1999 ; Robinson et al, 2002 ; Spiga et al, 2005 ; Diana et al, 2006 ; Christoffel et al, 2011a , b ; Golden et al, 2013 ; Pal and Das, 2013 ; Graziane et al, 2016 ; Guegan et al, 2016 ; Kobrin et al, 2016 ; Francis et al, 2017 ; Cahill et al, 2018 ; Geoffroy et al, 2019 ; Fox et al, 2020a , b ).…”

Section: Introductionmentioning

confidence: 99%

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Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice

Franco

Wulff

Lobo

et al. 2022

Front. Behav. Neurosci.

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Chronic stress can increase the risk of developing a substance use disorder in vulnerable individuals. Numerous models have been developed to probe the underlying neurobiological mechanisms, however, most prior work has been restricted to male rodents, conducted only in rats, or introduces physical injury that can complicate opioid studies. Here we sought to establish how chronic psychosocial stress influences fentanyl consumption in male and female C57BL/6 mice. We used chronic social defeat stress (CSDS), or the modified vicarious chronic witness defeat stress (CWDS), and used social interaction to stratify mice as stress-susceptible or resilient. We then subjected mice to a 15 days fentanyl drinking paradigm in the home cage that consisted of alternating forced and choice periods with increasing fentanyl concentrations. Male mice susceptible to either CWDS or CSDS consumed more fentanyl relative to unstressed mice. CWDS-susceptible female mice did not differ from unstressed mice during the forced periods, but showed increased preference for fentanyl over time. We also found decreased expression of nucleus accumbens Rho GTPases in male, but not female mice following stress and fentanyl drinking. We also compare fentanyl drinking behavior in mice that had free access to plain water throughout. Our results indicate that stress-sensitized fentanyl consumption is dependent on both sex and behavioral outcomes to stress.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice

Franco

Wulff

Lobo

et al. 2022

Front. Behav. Neurosci.

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“…Comorbidity between SUDs and depression is markedly frequent (Hasin et al., 2018), with research suggesting that many of the same neurobiological circuits and molecular mechanisms regulate the reward pathways that are disrupted in both types of nosological entities (Calarco & Lobo, 2021). Furthermore, individuals who have faced adverse childhood experiences are more likely to exhibit comorbid SUD and depression (Philogene‐Khalid et al., 2020), and such co‐occurrence is related to a significant increase in suicide risk (Hawton, Casañas i Comabella, Haw, & Saunders, 2013).…”

Section: Discussionmentioning

confidence: 99%

The mediating role of tolerance for psychological pain in the relationship of childhood trauma to suicidal ideation in individuals with a substance use disorder

Martins

Campos

Morujão

2021

British J Clinic Psychol

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Objectives The association between childhood trauma and suicidal ideation has been well documented in several populations, including individuals with a substance use disorder (SUD). However, a gap still exists in the literature regarding the mechanisms by which childhood trauma later impacts suicide risk. This cross‐sectional study tested the effect of childhood trauma on suicidal ideation, as well as the mediating effect of tolerance for psychological pain (managing the pain and enduring the pain) in that relationship, controlling for the effect of depressive symptoms, in individuals with a SUD. Methods A sample of 102 adults with a SUD participated in the study. Path analysis by structural equation modelling tested a mediation model. Results Depressive symptoms and lower levels of managing the pain were found to fully mediate the association between childhood trauma and suicidal ideation. Conclusions Our results suggest that depressive symptoms and a lack of ability to manage psychological pain contribute towards explaining why traumatic childhood experiences may result in suicidal cognitions in individuals with SUDs. Moreover, they have relevant implications for prevention and clinical interventions regarding suicidal ideation in this population. Practitioner points Childhood trauma relates to suicidal ideation in individuals with a substance use disorder. Depressive symptoms contribute towards explaining why traumatic childhood experiences may result in suicidal cognitions. A lack of ability to manage psychological pain also contributes towards explaining this relationship. The obtained results have relevant implications for the prevention of and clinical intervention for suicidal ideation in SUD individuals.

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“…Since anhedonia and reduced motivation are associated with substance use and dependence (Hatzigiakoumis et al, 2011), we included stress-susceptibility as a factor in our analysis. Finally, we examined how exposure to stress and fentanyl alters expression of dendritic complexity molecules in the Nucleus Accumbens (NAc), a region that is sensitive to both drugs and stress (Hollon et al, 2015;Newman et al, 2018;Calarco and Lobo, 2020). Here we show fentanyl preference after stress is dependent on sex and stress-phenotype, and is associated with altered expression of cytoskeleton-related molecules in the NAc.…”

Section: Introductionmentioning

confidence: 97%

“…A wealth of literature has sought to uncover how stress drives increased susceptibility to substance use, and the neurobiological underpinnings of comorbid stress and substance use disorders (For recent reviews see: (Newman et al, 2018;Calarco and Lobo, 2020). Psychosocial stress is of particular interest as it is thought to more closely mimic human stressors.…”

Section: Introductionmentioning

confidence: 99%

Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice

Franco

Wulff

Lobo

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Chronic stress can increase the risk of developing a substance use disorder in vulnerable individuals. Numerous models have been developed to probe the underlying neurobiological mechanisms, however most prior work has been restricted to male rodents, conducted only in rats, or introduces physical injury that can complicate opioid studies. Here we sought to establish how chronic psychosocial stress influences fentanyl consumption in male and female C57BL/6 mice. We used chronic social defeat stress (CSDS), or the modified vicarious chronic witness defeat stress (CWDS), and used social interaction to stratify mice as stress-susceptible or resilient. We then subjected mice to a 15 day fentanyl drinking paradigm in the home cage that consisted of alternating forced and choice periods with increasing fentanyl concentrations. Male mice susceptible to either CWDS or CSDS consumed more fentanyl relative to unstressed mice, and exhibited increased preference for fentanyl. CWDS-susceptible female mice did not differ from unstressed mice during the forced periods, but showed increased preference for fentanyl. We also found decreased expression of nucleus accumbens Rho GTPases in male, but not female mice following stress and fentanyl drinking. We also compare fentanyl drinking behavior in mice that had free access to plain water throughout. Our results indicate that stress-sensitized fentanyl consumption is dependent on both sex and behavioral outcomes to stress.

show abstract

Depression and substance use disorders: Clinical comorbidity and shared neurobiology

Cited by 33 publications

References 241 publications

Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice

Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice

The mediating role of tolerance for psychological pain in the relationship of childhood trauma to suicidal ideation in individuals with a substance use disorder

Chronic Physical and Vicarious Psychosocial Stress Alter Fentanyl Consumption and Nucleus Accumbens Rho GTPases in Male and Female C57BL/6 Mice

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