Depression and treatment outcome in anorexia nervosa

Specialized inpatient treatment of adult anorexia nervosa: effectiveness and clinical significance of changes

“…This contrasts with previous studies which have shown that depressive symptoms are a negative predictor of treatment outcome [43]. Furthermore, Calugi et al [44] showed that there were no differences in outcome between eating disorder patients with or without a comorbid major depressive disorder. Our results should be interpreted carefully since comorbidity was not assessed by a structured clinical interview such as the Structured Clinical Interview for DSM Disorders [45], but rather based on expert opinion.…”

Heterogeneous weight restoration trajectories during partial hospitalization treatment for anorexia nervosa

“…Findings that the absence of a comorbid mood disorder was associated with rapid weight gain is in contrast to a study finding that a diagnosis of major depression did not influence the outcome of treatment for those with AN (Calugi, El Ghoch, Conti, & Dalle Grave, 2014). However, the study assessed inpatient as opposed to intensive outpatient treatment in a sample of adults rather than adolescents.…”

Network analysis of specific psychopathology and psychiatric symptoms in patients with anorexia nervosa

“…Hence, effective treatments targeting network of symptoms rather than individual symptoms are expected to focus on central nodes in order to dismantle psychopathologic and symptomatic loops that maintain AN (Costantini et al, 2014). It is still debated whether depression has (Wild et al, 2016) or does not have (Calugi, El Ghoch, Conti, & Dalle Grave, 2014) a prognostic role in determining outcome in AN (hence, any eventual prognostic implication of depressive symptoms' centrality is precluded). On the other hand, a large body of evidence suggests that psychotherapy encompassing wider than "mere" ED-core symptoms psychopathologic aspects, namely, family therapy (FT; Eisler et al, 2016) and enhanced cognitive behavioural therapy (E-CBT) in adolescents (Dalle Grave, Calugi, Doll, & Fairburn, 2013), interpersonal psychotherapy (Linardon, Fairburn, Fitzsimmons-Craft, Wilfley, & Brennan, 2017), or Maudsley model for adults (MANTRA; Schmidt et al, 2015) in adults is an effective treatment for AN.…”