Depression, anxiety, and dermatologic quality of life in adolescents with atopic dermatitis

Slattery, Marcia J.; Essex, Marilyn J.; Paletz, Elliott M.; Vanness, Erin; Infante, Mauricio; Rogers, Gregory M.; Gern, James E.

doi:10.1016/j.jaci.2011.05.003

Cited by 118 publications

(86 citation statements)

References 20 publications

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“…13 These children may be at higher risk of depression, anxiety, and other mental health disorders. 14 AD also has a negative effect on QoL of caregivers and parents of affected children. 15 Parents of children with moderate and severe AD spend up to 3 hours per day caring for their children' s skin.…”

Section: Effects On Quality Of Lifementioning

confidence: 99%

Atopic Dermatitis: Skin-Directed Management

Tollefson¹,

Bruckner²,

Dermatology³

2014

Pediatrics

111

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Atopic dermatitis is a common inflammatory skin condition characterized by relapsing eczematous lesions in a typical distribution. It can be frustrating for pediatric patients, parents, and health care providers alike. The pediatrician will treat the majority of children with atopic dermatitis as many patients will not have access to a pediatric medical subspecialist, such as a pediatric dermatologist or pediatric allergist. This report provides up-to-date information regarding the disease and its impact, pathogenesis, treatment options, and potential complications. The goal of this report is to assist pediatricians with accurate and useful information that will improve the care of patients with atopic dermatitis. Pediatrics 2014;134:e1735-e1744Atopic dermatitis (AD), commonly referred to as eczema, is a chronic, relapsing, and often intensely pruritic inflammatory disorder of the skin. A recent epidemiologic study using national data suggested that the pediatric prevalence is at least 10% in most of the United States. 1 AD primarily affects children, and disease onset occurs before the ages of 1 and 5 years in 65% and 85% of affected children, respectively. 1 The number of office visits for children with AD is increasing. 2 Up to 80% of children with AD are diagnosed and managed by primary care providers, often pediatricians. 3 Although medical subspecialists, such as pediatric dermatologists and/or pediatric allergists, may be suited to provide more advanced care for children with AD, lack of a sufficient number of such physicians, particularly pediatric dermatologists, 4 likely means the burden of AD care will continue to fall to primary care providers. Although consensus guidelines and practice parameters regarding the management of AD in children have been published, 5-10 considerable variability persists in clinical practice, particularly regarding the roles that bathing, moisturizing, topical medications, and allergies play in management. Inconsistencies in opinion and treatment approach as well as the chronic and relapsing nature of AD can lead to frustration for the patient, family, and primary care providers when managing AD. STATEMENT OF THE PROBLEMNew data support the theory that AD results from primary abnormalities of the skin barrier, 11 suggesting that skin-directed management of AD is of paramount importance. This clinical report reviews AD and provides an up-to-date approach to skin-directed management that is based on pathogenesis. Effectively using this information to create treatment plans

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Section: Effects On Quality Of Lifementioning

confidence: 99%

Atopic Dermatitis: Skin-Directed Management

Tollefson¹,

Bruckner²,

Dermatology³

2014

Pediatrics

111

View full text Add to dashboard Cite

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“…A recent study documents the negative psychosocial effect of AD on quality of life that occurs as the result of excessive itching, sleep loss, and social embarrassment, as well as increasing recognition of depression and anxiety in patients with this common skin disease. 83 Studies in the Journal have highlighted factors that contribute to the development and severity of AD. These include obesity, which is associated with more severe AD.…”

Section: Allergic Skin Diseasesmentioning

confidence: 99%

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2011

Sicherer

Leung

2012

Journal of Allergy and Clinical Immunology

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This review highlights some of the research advances in anaphylaxis; hypersensitivity reactions to foods, drugs, and insects; and allergic skin diseases that were reported in the Journal in 2011. Food allergy appears to be increasing in prevalence and carries a strong economic burden. Risk factors can include dietary ones, such as deficiency of vitamin D and timing of complementary foods, and genetic factors, such as filaggrin loss-of-function mutations. Novel mechanisms underlying food allergy include the role of invariant natural killer T cells and influences of dietary components, such as isoflavones. Among numerous preclinical and clinical treatment studies, promising observations include the efficacy of sublingual and oral immunotherapy, a Chinese herbal remedy showing promising in vitro results, the potential immunotherapeutic effects of having children ingest foods with baked-in milk if they tolerate it, and the use of anti-IgE with or without concomitant immunotherapy. Studies of allergic skin diseases, anaphylaxis, and hypersensitivity to drugs and insect venom are elucidating cellular mechanisms, improved diagnostics, and potential targets for future treatment. The role of skin barrier abnormalities, as well as the modulatory effects of the innate and adaptive immune responses, are major areas of investigation.

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“…5 Hastalık anksiyete, depresyon gelişimine yol açmakta ve hastaların yaşam kalitesini olumsuz yönde etkilemektedir. 6 Çalışmaların birçoğunda kızlarda erkeklere göre görülme oranı bir miktar daha fazla olarak bulunmuştur. Hastalık çev-resel ve genetik faktörlerin etkileşimi sonucu gelişmektedir.…”

Section: Epidemiyolojiunclassified

“…Kromozom 5q31-33, T hepler (Th) 2 sitokinlerden IL-3, IL-4, IL-5, IL-13 ve granulosit makrofaj koloni sitimulan faktör (GMKSF) ile ilişkili genleri içerir. 1,3,6 Kromozom bölgelerinden 3q21'in ve 5q31'in artmış serum IgE ve atopi ile ilişkisi bulunmuştur. Bu lokustaki genler T hücre aktivasyonu ve Th2 sitokinlerin ekspresyonunda görevli molekülleri kodlamaktadır.…”

Section: Genetik Faktörlerunclassified

Atopik Dermatit

Alper¹,

Türk²

2011

Turkderm

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ÖzetAtopik dermatit sanayileşmiş toplumlarda önemli bir sağlık sorunu olarak karşımıza çıkarken, gelişmekte olan ülkemizde ise sıklığı giderek artış göstermektedir. Sum maryAtopic dermatitis is one of the important public health problems of the industrialized communities, and the prevalence of the disease has been increasing in our developing country. In this paper, etiopathogenesis, clinical characteristics and current therapeutic approaches of atopic dermatitis is reviewed under highlights of recently published guidelines and the literature. (Turk derm 2011; 45: 168-73

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Depression, anxiety, and dermatologic quality of life in adolescents with atopic dermatitis

Cited by 118 publications

References 20 publications

Atopic Dermatitis: Skin-Directed Management

Atopic Dermatitis: Skin-Directed Management

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2011

Atopik Dermatit

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