Depression, anxiety, post-traumatic stress, and alcohol-related problems among veterans with chronic hepatitis C

Lehman, Cassandra L.; Cheung, Ramsey

doi:10.1111/j.1572-0241.2002.06042.x

Cited by 70 publications

(26 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One healthcare system in the United States that has extensively evaluated the impact of contraindications on initiation of HCV therapy is the Veterans Administration (VA) Medical System. Hepatitis C infection in this population is roughly 2–3 times more prevalent than in the general population and has been associated with high rates of psychiatric disorders and substance abuse . The VA has a relatively closed network that utilises large electronic databases to connect VA clinics throughout the United States.…”

Section: Introductionmentioning

confidence: 99%

“…While the impact of contraindications and treatment eligibility has been extensively evaluated in the VA system, limited data exist on the frequency of contraindications to PEG‐IFN/RBV in the general US population . The current analysis utilised a large nationwide electronic database to determine the percentage of patients in the general population with HCV who would be ineligible for therapy with PEG‐IFN plus RBV because of contraindications.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Absolute and relative contraindications to pegylated‐interferon or ribavirin in the US general patient population with chronic hepatitis C: results from a US database of over 45 000 HCV‐infected, evaluated patients

Talal

LaFleur

Hoop³

et al. 2013

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Absolute and relative contraindications to pegylated‐interferon or ribavirin in the US general patient population with chronic hepatitis C: results from a US database of over 45 000 HCV‐infected, evaluated patients

Talal

LaFleur

Hoop³

et al. 2013

Aliment Pharmacol Ther

View full text Add to dashboard Cite

show abstract

“…A correlation between the intensity of anxiety disorders and the occurrence of depression and alcoholism has been stated. 18 Czarnecki et al report an association between viremia, hepatic inflammation activity and the intensity of depression and anxiety disorders. 19 Pawłowski et al likewise stated a correlation between the level of depression, neuroticism and the viremia of HCV positive patients.…”

Section: Depression Anxiety Sleep Disordersmentioning

confidence: 99%

“…Increased levels of these hormones are characteristic of MDD (major depressive disorder) and anxiety disorders. 16,18 . Moreover, IFN is an activator of pro-inflammatory cytokines: IL-1, IL-6 and TNFα.…”

Section: Ifn and Daas Therapymentioning

confidence: 99%

“…Valproic acid requires liver functions monitoring, whereas carbamazepine and oxcarbazepine may result in bone marrow suppression, thus are contraindicated during IFN therapy. 18 Haloperidol, quetiapine and aripiprazole are regarded presumably safe antipsychotics. Risperidone requires liver functions monitoring, whereas olanzapine and clozapine are contraindicated.…”

Section: Psychopharmacology In Hcv Infectionmentioning

confidence: 99%

See 1 more Smart Citation

The neuropsychiatric aspect of the HCV infection

Więdłocha¹,

Marcinowicz²,

Sokalla³

et al. 2017

Adv Clin Exp Med

View full text Add to dashboard Cite

HCV infection is significantly more prevalent in the population of psychiatric patients, drug addicts and people tending to undertake risky sexual behaviors than in the general population. This article presents a spectrum of psychopathological symptoms and psychological dysfunctions, an outline of current theories on the neuropathology and psychiatric aspects of HCV infection treatment. The unspecific character of the psychopathological symptoms in the HCV infection makes the process of thorough diagnostics and adequate treatment difficult, thus the specific and characteristic features have been emphasized. The aim of this review is to shed light not only on the basic information concerning CNS pathology but also on the conclusions emerging from the studies of different authors, of various methodology, in diverse study groups and also to investigate current topics of research. The results of neuroimaging studies have been presented as well. Attention has also been dedicated separately to specific issues, like psychiatric aspects of co-infection with HCV and HIV viruses, the chronic fatigue in the course of HCV infection, the influence of substance use disorders and difficulties encountered during treatment with interferon. Undiagnosed psychiatric disorders, not only inevitably decrease the already rather low quality of life but also cause non-adherence with recommendations and medications regimes, contributing to a worse treatment outcome. Finally, the above disorders, when left untreated, result in higher rates of risk-taking behaviors among the infected, thus imposing a danger not only to patients themselves but also to the healthy population.

show abstract