Depression, Apathy, Anhedonia, and Fatigue in Parkinson’s Disease

Abstract

Depression in PD Defi nition and Pathophysiology Defi nitionDepression is a common neuropsychiatric disorder characterized by the persistence and pervasiveness of a spectrum of symptoms that can variously aggregate. These symptoms include: depressed mood, loss of interest/pleasure, loss or gain in weight or appetite, insomnia or hypersomnia, psychomotor agitation, fatigue, feelings of worthlessness or guilt, diminished ability to think or concentrate, indecisiveness, thoughts of death, and suicidal ideation.