Depression as a determinant of frailty in late life

Borges, Marcus Kiiti; Aprahamian, Ivan; Romanini, C; Oliveira, Fabiana Maria Rodrigues Lopes de; Mingardi, Silvana Vieira Bandeira; Lima, Natália Almeida; Cecato, Juliana Francisca; Petrella, Marina; Voshaar, Richard C. Oude

doi:10.1080/13607863.2020.1857689

Cited by 31 publications

(26 citation statements)

References 52 publications

(66 reference statements)

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“…FP, classified as robust , pre-frail , and frail , was operationally defined as having reported weight loss, weakness, exhaustion, slowness, or low physical activity [ 2 ]. The level of frailty was determined using the number of criteria present ( robust , none; pre-frail, 1–2; frail , 3 or more criteria) described in Supplementary Table 1 using data elements available in KNHANES data similar to other published studies [ 5 , 19 ]. FP was considered missing for participants who had missing values for any of the five criteria; survey data from the years 2014, 2016, and 2018 were used because information on all five criteria was complete only in these years.…”

Section: Methodsmentioning

confidence: 99%

“…Frailty was also operationally defined using the FI, a ratio of health deficits present to the total number of health deficits considered, i.e., 44 deficit criteria described in Supplementary Table 2 selected and scored on a scale of 0 (absence of a deficit) to 1 (full expression of the deficit), according to a standard protocol [ 6 ] using data elements available in KNHANES data similar to other published studies [ 5 , 19 – 21 ]. The level of frailty was determined using previously reported cut-off values ( robust, FI ≤ 0.08; pre-frail , 0.08–0.25; frail, FI ≥ 0.25) [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

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Association between oral health and frailty: results from the Korea National Health and Nutrition Examination Survey

Kim

Lee

2022

BMC Geriatr

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Background Previous research has suggested that poor oral health is positively associated with frailty. The objective of this study was to explore associations of key oral diseases (periodontal disease, tooth loss), and oral hygiene and management behaviors with the level of frailty in community-dwelling older Korean adults using national representative survey data. Methods This study used cross-sectional, 6th and 7th Korea National Health and Nutrition Examination Survey (KNHANES VI, VII) data. Adults aged 50+ years were included. Frailty was measured using frailty phenotype (FP) and frailty index (FI). FP was determined using five frailty criteria, i.e., weight loss, weakness, exhaustion, slowness, or low physical activity, and the level of frailty was classified with the number of criteria present (robust, none; pre-frail, 1–2; frail, 3+). FI was determined using a 44-item FI constructed according to a standard protocol, and the level of frailty was classified as robust (FI: ≤ 0.08), pre-frail (FI: 0.08–0.25), and frail (FI: ≥ 0.25). Multiple ordinal regression analyses were conducted with each type of frailty as the outcome variable. Independent variables of interest were the periodontal status, number of teeth, and practices on oral hygiene and management. Analyses were additionally adjusted for participants’ socioeconomic, diet, and behavioral characteristics. Results The prevalence of frailty was 4.38% according to the FP classification (n = 4156), 10.74% according to the FI classification (n = 15,073). In the final adjusted model, having more teeth and brushing after all three meals were significantly associated with lower odds of being more frail (in both frailty models); no significant association was observed between periodontal disease and frailty. Conclusions Findings from this study show having more teeth and practicing adequate brushing are significantly associated with frailty. Due to limitations of the study design, well-designed longitudinal studies are needed to confirm these findings.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Association between oral health and frailty: results from the Korea National Health and Nutrition Examination Survey

Kim

Lee

2022

BMC Geriatr

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“…Depression is considered one of the most common mental illnesses in late life [ 37 , 38 ]. Among others, feelings of loneliness, lack of social support, negative life events, loss of loved ones, living alone, frailty, and illness or disability are aspects inherent to late life-triggering depressive symptoms [ 39 , 40 , 41 , 42 , 43 ]. In geriatric patients living in Europe or in the United States, prevalent rates of depressive symptoms vary widely from 10% to 65% [ 13 , 44 , 45 , 46 , 47 ].…”

Section: Introductionmentioning

confidence: 99%

Religious Coping Styles and Depressive Symptoms in Geriatric Patients: Understanding the Relationship through Experiences of Integrity and Despair

Desmet

Dezutter

Vandenhoeck

et al. 2022

IJERPH

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Older persons are often confronted with challenging events in their lives. Religion can offer them a way to deal with these challenges. The study of religious coping styles helps us to understand how people find support in their religion or wrestle with aspects of their religion when they are confronted with difficulties. Especially when older adults face illness and hospitalization, religious coping styles might be triggered. Despite the fact that the public role of religion, especially Christianity, is diminishing in West European societies, a large group of Belgian geriatric patients call themselves religious. Previous studies have shown that there is a link between positive/negative religious coping styles and the depressive symptoms that often occur in older adults. More recently, some scholars have emphasized that this relationship is more complex. Therefore, this paper investigates the role of one possible underlying mechanism between positive/negative religious coping styles and depressive symptoms in geriatric patients, namely the developmental process of integrity and despair as two factors within this mechanism. One hundred thirty-nine geriatric inpatients from three hospitals in Belgium who reported to feel religiously affiliated were involved in this study. Our results indicate that experiences of integrity and despair function as an explanatory pathway in the relationship between negative religious coping styles and depressive symptoms. Further, a direct link was found between both when accounting for experiences of integrity and despair. For positive religious coping styles, no direct or indirect relationship with depressive symptoms was found. In healthcare, geriatric caregivers need to be aware of the interaction between positive and negative religious coping styles, the developmental process of integrity and despair, and depressive symptoms.

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“…An association between psychological factors such as cognitive impairment and depression, and physical conditions such as sarcopenia, has been reported [ 9 , 11 ]. In addition, frailty and depression are important conditions affecting older adults, and their relationship resulted to be robust ([ 12 , 13 ]).…”

Section: Introductionmentioning

confidence: 99%

Association between Perceived Health-Related Quality of Life and Depression with Frailty in the FRASNET Study

Zotti

Citterio

Farinone

et al. 2022

IJERPH

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Frailty is a major challenge facing the aging world. The phenotype of the frail subject is still far from being satisfactorily defined. We report data on mood, cognition, and quality of life (QoL) in relation to anamnestic factors, health, and socio-economic status in the FRASNET geriatric population (1204 subjects in stable health conditions), which is an observational cohort study that includes fairly balanced groups of Italian frail (421, 35%), pre-frail (449, 37.3%) and robust (334, 27.7%) subjects. A conditional inference tree analysis revealed a substantial influence of psychological variables on frailty. The physical indicator of QoL (Short Form Survey-36-Physical Component Summary, SF-36-PCS) was the predominant variable in the full model (threshold at 39.9, p < 0.001): higher frailty was found in subjects with a caregiver and lower SF-36-PCS. Frailty was also associated with the mental indicator of QoL (Short Form Survey-36-Mental Component Summary, SF-36-MCS), depression (Geriatric Depression Scale, GDS-15), leisure activities, and level of education. In support of the prominent role of inflammation in aging and mental illness, the SF-36-PCS score was correlated with the blood concentration of C-X-C motif chemokine ligand 10 (CXCL10) (r Pearson −0.355, p = 0.015), a critical signal in cell senescence and inflammaging, while the rs7567647 variant in FN1 gene encoding a glycoprotein in the extracellular matrix was significantly associated with frailty in a multivariable model (p = 0.0006). The perception of health-related QoL and subclinical depression contribute to frailty. Their assessment could improve the identification of older patients at increased risk of adverse outcomes.

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Depression as a determinant of frailty in late life

Cited by 31 publications

References 52 publications

Association between oral health and frailty: results from the Korea National Health and Nutrition Examination Survey

Association between oral health and frailty: results from the Korea National Health and Nutrition Examination Survey

Religious Coping Styles and Depressive Symptoms in Geriatric Patients: Understanding the Relationship through Experiences of Integrity and Despair

Association between Perceived Health-Related Quality of Life and Depression with Frailty in the FRASNET Study

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