Introduction: Athletes experience the same mental health disorders as the general population. When mental health symptoms or disorders are experienced more acutely, there may be occasions when the treating team needs to decide if it is in the best interest of the athlete to be removed from the sport environment for treatment and recovery. If an athlete has been away from the sport environment due to mental health symptoms or disorders, the treating team should be deliberate and collaborative in guiding their return. Removal-from-play (RFP) and return-to-play (RTP) decisions involving an athlete who has experienced mental health challenges can be complex. Methods: The literature around athlete mental health was reviewed to explore contributing and mitigating factors to mental health challenges in this population. General psychiatric recovery trajectories for selected mental illnesses were reviewed to inform RTP planning through and beyond illness episodes. The literature related to RFP and RTP for athletes in terms of specific physical factors (concussion and musculoskeletal injury) and mental health factors (specifically, depression, anxiety, and eating disorders) was also reviewed. Results: A scoping overview of athlete- and sport-specific factors yielded a framework that can be used to guide athlete support, RFP and RTP planning through and beyond mental health-related sport interruption. Conclusion: When mental health symptoms and disorders are present, decisions guiding RFP and RTP should be guided by clinical assessment of safety, stability and function. Due to the complex nature of mental disorders and the interaction of sport elements, it is recommended that sports psychiatrists are involved in the assessment and management process.