Depression bei Patienten mit Acne inversa – eine häufige Komorbidität

Kurek, Agata; Peters, Eva M.J.; Sabat, Robert; Sterry, Wolfram; Schneider‐Burrus, Sylke

doi:10.1111/ddg.12067_suppl

Cited by 11 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…11 Considering the impairment of quality of life that arises even with moderate disease severity, as well as the significant proportion of HS patients who additionally suffer from depression due to their condition, this timeframe must be shortened for the benefit of patients. [14][15][16][17][18][19] To achieve this, the causes of the diagnos- tic delay must be understood, and potential improvements identified. 20 For this investigation, public internet posts from patients with HS were analyzed to better understand the patient pathway and experience beyond traditional clinical studies.…”

Section: Discussionmentioning

confidence: 99%

“…Recent research has revealed that it takes an average of ten years from the onset of the first symptoms of HS to the correct diagnosis 11 . Considering the impairment of quality of life that arises even with moderate disease severity, as well as the significant proportion of HS patients who additionally suffer from depression due to their condition, this timeframe must be shortened for the benefit of patients 14–19 . To achieve this, the causes of the diagnostic delay must be understood, and potential improvements identified 20 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic delay in Hidradenitis suppurativa investigated using data from social media and from statutory health insurances

Kirschner,

Kahn,

Papukchieva

et al. 2024

J Deutsche Derma Gesell

View full text Add to dashboard Cite

SUMMARYBackgroundThe chronic inflammatory skin disease hidradenitis suppurativa (HS) leads to severe pain and reduced quality of life. Nonetheless, it often takes years until a correct diagnosis is made. In this analysis, disease‐related experiences and pathways of patients with HS were investigated and compared with the physicians’ perspective.MethodsPublic posts on forums and social media as well as results of a survey conducted among dermatologists and their patients on the actual medical care reality of HS in Germany were analysed. Furthermore, claims data from German health insurance companies were evaluated.ResultsPatients with HS suffer from a 43.3% reduction in working ability. Dermatology (26.5%) was the most frequently consulted specialty, with HS diagnosed predominantly in the inpatient setting (43.8%). Abscesses were described as the most frequent alternative diagnosis in HS patients (53.2%). Patient‐reported changes of physicians in dermatology (34.1%) and surgery (42.4%) occurred predominantly within the specialty. Dermatology received most referrals from general practitioners (67.1%), but only 12.1% from surgeons.ConclusionThere is an urgent need to reduce the delay in diagnosis and the prolonged burden of disease in patients with HS. Therefore, awareness of the disease, its detection and treatment which goes beyond dermatology should be promoted, if possible as part of medical studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diagnostic delay in Hidradenitis suppurativa investigated using data from social media and from statutory health insurances

Kirschner,

Kahn,

Papukchieva

et al. 2024

J Deutsche Derma Gesell

View full text Add to dashboard Cite

show abstract

“…11 Betrachtet man die Beeinträchtigung der Lebensqualität, die bereits bei einer moderaten Krankheitsausprägung entsteht, sowie den großen Anteil an Patienten mit HS, die aufgrund ihrer Erkrankung zusätzlich an einer Depression leiden, muss diese Zeitspanne zum Wohle der Patienten verkürzt werden. [14][15][16][17][18][19] Dazu müssen die Ursachen für diese Diagnoseverzögerung verstanden und mögliche Verbesse-rungen identifiziert werden. 20 Für die Untersuchung wurden dazu öffentliche Internet-Beiträge von Patienten mit HS analysiert, um abseits klassischer klinischer Studien die Patientenwege der Betroffenen besser nachzuvollziehen.…”

Section: Diskussionunclassified

“…Aktuelle Forschungsarbeiten konnten zeigen, dass vom Auftreten der ersten Symptome der HS bis zur korrekten Diagnosestellung durchschnittlich zehn Jahre vergehen 11 . Betrachtet man die Beeinträchtigung der Lebensqualität, die bereits bei einer moderaten Krankheitsausprägung entsteht, sowie den großen Anteil an Patienten mit HS, die aufgrund ihrer Erkrankung zusätzlich an einer Depression leiden, muss diese Zeitspanne zum Wohle der Patienten verkürzt werden 14–19 . Dazu müssen die Ursachen für diese Diagnoseverzögerung verstanden und mögliche Verbesserungen identifiziert werden 20 .…”

Section: Diskussionunclassified

Diagnoseverzögerung bei Hidradenitis suppurativa untersucht mit Daten von sozialen Medien und gesetzlichen Krankenversicherungen

Kirschner,

Kahn,

Papukchieva

et al. 2024

J Deutsche Derma Gesell

View full text Add to dashboard Cite

ZusammenfassungHintergrundDie chronisch‐entzündliche Hauterkrankung Hidradenitis suppurativa (HS) führt bei Betroffenen zu ausgeprägten Schmerzen und verminderter Lebensqualität. Trotzdem vergehen oft mehrere Jahre bis zur korrekten Diagnosestellung. In dieser Analyse sollten krankheitsbedingte Erfahrungen und Wege der Patienten mit HS untersucht und der ärztlichen Sicht gegenübergestellt werden.Patienten und MethodikFür die Studie wurden Ergebnisse einer Befragung von Dermatologen und deren Patienten zur Versorgungsrealität bei HS in Deutschland sowie öffentliche Beiträge auf Internet‐Foren und in sozialen Medien analysiert. Zusätzlich wurden Abrechnungsdaten deutscher Krankenkassen ausgewertet.ErgebnissePatienten mit HS haben eine um 43,3% reduzierte Arbeitsfähigkeit. Die Dermatologie (26,5%) war der am häufigsten konsultierte Fachbereich, die Diagnose HS wurde dabei überwiegend im stationären Bereich (43,8%) gestellt. Als häufigste alternative Diagnose bei HS‐Patienten wurden Abszesse angegeben (53,2%). Die Analyse von Wechseln zu anderen Behandlern ergab, dass diese in der Dermatologie (34,1%) und der Chirurgie (42,4%) vorwiegend innerhalb des Fachbereiches erfolgen. Überweisungen erhielt die Dermatologie mehrheitlich aus dem hausärztlichen Bereich (67,1%) allerdings nur 12,1% von Chirurgen.SchlussfolgerungenDie Diagnoseverzögerung und die dadurch verlängerte Krankheitsbelastung von Patienten mit HS muss dringend reduziert werden. Dazu sollte, möglichst schon als Teil des Medizinstudiums, ein über die Dermatologie hinaus reichendes Bewusstsein für die Erkrankung, ihre Erkennung und Behandlung gefördert werden.

show abstract

Isotretinoin update

Marson

Baldwin

2021

Dermatological Reviews

View full text Add to dashboard Cite

Background Acne is a common, chronic inflammatory condition seen in nearly all teenagers and many adult females, with a global lifetime prevalence between 70‐85%. While a majority of individuals with acne can be appropriately managed with a combination of topical therapies, oral antibiotics, and/or oral anti‐androgens, 10‐20% of individuals will have acne severe enough to warrant isotretinoin. When necessary, isotretinoin is highly effective and the only drug to offer the likelihood of a durable response. Aims To review the literature regarding known adverse effects of isotretinoin therapy and nuances during and post‐isotretinoin therapy important to patient care. Materials and Methods A literature search was conducted for original, English‐language case reports, case series, original studies and/or meta‐analyses published between 1982‐2021 on isotretinoin, related adverse effects, and laboratory assessment and treatment nuances during and after a course of isotretinoin. Results Adverse events categories include mucocutaneous (e.g., xerosis, cheilitis, epistaxis), ocular (xerophthalmia, nyctalopia, blepharitis, conjunctivitis), non‐specific gastrointestinal, musculoskeletal (myalgia, pre‐mature epiphyseal plate closure, DISH), neurologic (idiopathic intracranial hypertension, hearing loss, tinnitus). Most adverse events are mild, self‐limiting, and/or resolve with drug discontinuation. Teratogenicity is of utmost concern especially given the risk of patient nonadherence to iPLEDGE precautions. Laboratory testing at baseline and after month 2 of therapy or upon reaching maximum daily dose may be sufficient. Utilizing creatine kinase and gamma‐glutamyl transferase in lieu of aspartate aminotransferase and alanine aminotransferase may better assess hepatic function during treatment. Improved formulations of isotretinoin may improve absorption and decrease reliance on patient adherence to a high‐fat diet. Dermabrasion and fully ablative laser procedures should be avoided in the immediate post‐isotretinoin period. Discussion Although adverse events associated with isotretinoin therapy are common, a majority of side effects are limited, self‐resolving (with completion of treatment course) without long‐term implications, and/or easily managed. Unfortunately, the advent of the internet and social media has given a platform to misleading law‐firm claims and medical pseudoscience inaccuracies that may frighten patients in need of treatment, ultimately delaying or even preventing therapy. Conclusion It is important that physicians are knowledgeable about the nuances of isotretinoin therapy, including efficacy, real potential adverse events, and appropriate laboratory monitoring. By honing this expertise, physicians may confidently counsel and guide patients through a course of isotretinoin to achieve a more permanent solution for their acne and improve their quality of life.

show abstract

Depression bei Patienten mit Acne inversa – eine häufige Komorbidität

Abstract: Patients with AI have a higher risk of developing depression. Physicians should be alert to the possible development of depression when treating patients with this disorder.

Cited by 11 publications

References 40 publications

Diagnostic delay in Hidradenitis suppurativa investigated using data from social media and from statutory health insurances

Diagnostic delay in Hidradenitis suppurativa investigated using data from social media and from statutory health insurances

Diagnoseverzögerung bei Hidradenitis suppurativa untersucht mit Daten von sozialen Medien und gesetzlichen Krankenversicherungen

Isotretinoin update

Contact Info

Product

Resources

About