Depression, body mass index, and chronic obstructive pulmonary disease &amp;ndash; a holistic approach

Catalfo, G.; Crea, Luciana; Castro, Tiziana Lo; Lio, F.M.; Minutolo, Giuseppe; Siscaro, Gherardo; Vaccino, Noemi; Crimi, Nunzio; Aguglia, Eugenio

doi:10.2147/copd.s84347

Cited by 8 publications

(8 citation statements)

References 49 publications

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“…Our findings are consistent with others who reported that elderly patients (whose mean age is 71 years) achieved a clinically significant reduction in depression following rehabilitation 30,31. Moreover, our findings are consistent with studies that concluded that patients over 71 attained similar alleviation from depression, but also that elderly patients should not be excluded from pulmonary rehabilitation 20.…”

Section: Discussionsupporting

confidence: 93%

Does pulmonary rehabilitation alleviate depression in older patients with chronic obstructive pulmonary disease

Alsaraireh

Aloush

2017

SMJ

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Objectives:To identify if pulmonary rehabilitation can achieve a clinically significant alleviation in the level of depression among chronic obstructive pulmonary disease (COPD) patients older than 70 years.Methods:We conducted a retrospective secondary analysis of the patients’ electronic records from a major pulmonary rehabilitation center in Cleveland, OH, United States between 2010 and 2014. Profiles of 105 participants who had completed more than 6 pulmonary rehabilitation sessions and were older than 70 years at the time of enrollment in the program were included. The Beck Depression Inventory scores at the baseline and the end of the pulmonary rehabilitation sessions were compared.Results:There was a statistically and clinically significant reduction in mean scores of depression from the baseline to the end of pulmonary rehabilitation: mean± SD: 104±5.6; p=0.00. The mean±SD depression score at the end was 9±4.3 compared with the baseline 17±7.8. Seventy-seven (73%) participants showed clinically significant improvement in depression; however, 20 participants (27%) had no clinically significant improvement, and 8 (8%) had worse depression at the end of pulmonary rehabilitation. Participants with higher depression scores at the baseline were 1.3 times more likely to achieve clinically significant alleviation in depression at the end of rehabilitation (odds ratio = 1.3, p=0.00).Conclusion:Pulmonary rehabilitation induced clinically significant alleviation in depression among participants with COPD aged over 70 years.

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Section: Discussionsupporting

confidence: 93%

Does pulmonary rehabilitation alleviate depression in older patients with chronic obstructive pulmonary disease

Alsaraireh

Aloush

2017

SMJ

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“…Characterizing disturbance of mood by the Impacts component score of the SGRQ may also be viewed as a possible shortcoming. Identification of depression based on the Diagnostic and Statistical Manual of Mental Disorders 5 may prove to be challenging as accompanying somatic symptoms could be secondary to either depression or COPD 43. Furthermore, utility of certain diagnostic instruments, for example, hospital anxiety and depression scale, has been questioned with respect to their accuracy in COPD patients 59.…”

Section: Discussionmentioning

confidence: 99%

Alteration of the irisin–brain-derived neurotrophic factor axis contributes to disturbance of mood in COPD patients

Papp¹,

Pák²,

Erdei³

et al. 2017

COPD

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COPD is accompanied by limited physical activity, worse quality of life, and increased prevalence of depression. A possible link between COPD and depression may be irisin, a myokine, expression of which in the skeletal muscle and brain positively correlates with physical activity. Irisin enhances the synthesis of brain-derived neurotrophic factor (BDNF), a neurotrophin involved in reward-related processes. Thus, we hypothesized that mood disturbances accompanying COPD are reflected by the changes in the irisin–BDNF axis. Case history, routine laboratory parameters, serum irisin and BDNF levels, pulmonary function, and disease-specific quality of life, measured by St George’s Respiratory Questionnaire (SGRQ), were determined in a cohort of COPD patients (n=74). Simple and then multiple linear regression were used to evaluate the data. We found that mood disturbances are associated with lower serum irisin levels (SGRQ’s Impacts score and reciprocal of irisin showed a strong positive association; β: 419.97; 95% confidence interval [CI]: 204.31, 635.63; P<0.001). This association was even stronger among patients in the lower 50% of BDNF levels (β: 434.11; 95% CI: 166.17, 702.05; P=0.002), while it became weaker for patients in the higher 50% of BDNF concentrations (β: 373.49; 95% CI: −74.91, 821.88; P=0.1). These results suggest that irisin exerts beneficial effect on mood in COPD patients, possibly by inducing the expression of BDNF in brain areas associated with reward-related processes involved in by depression. Future interventional studies targeting the irisin–BDNF axis (eg, endurance training) are needed to further support this notion.

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“…In puberty, significant changes in body composition occur and need to be taken into account for the longitudinal examination of youth with BSD ( 48 ). A positive association between fat mass and depressive symptoms exists ( 98 , 99 ). Among many pathways, depressive symptoms may cause lipid dysregulation resulting in increased fat accumulation ( 82 ).…”

Section: Body Composition and Mood Disordersmentioning

confidence: 99%

Bipolar Spectrum Disorders in Male Youth: The Interplay between Symptom Severity, Inflammation, Steroid Secretion, and Body Composition

Walther

Penz

Ijacic³

et al. 2017

Front. Psychiatry

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The morbidity and societal burden of youth bipolar spectrum disorders (BSD) are high. These disorders are multisystemic in that adult populations there are clear interactions with inflammatory processes and steroidal physiological systems. There are much less data concerning these areas of study in youth populations with BSD. This is surprising given the association of youth-onset BSD with puberty and its associated physiological changes. In this mini-review, we overview the theoretical role of inflammatory processes and steroidal physiological systems in youth BSD, describe the greater literature in adult populations, detail the literature in youth populations when available, and overview current proposed molecular mechanistic pathways and interaction effects based on the available data. We also attend to the interplay of this complex system with body composition and weight gain, an especially important consideration in relation to the role of second generation antipsychotics as the first line treatment for youth with BSD in major clinical guidelines. A developmental model of early onset BSD for boys is hypothesized with pubertal hormonal changes increasing risk for first (hypo-)manic/depressive episode. The dramatic androgen rise during puberty might be relevant for first onset of BSD in boys. A shift from general hypercortisolism driven by glucocorticoid resistance to hypocortisolism with further disease progression is assumed, while increased levels of inflammation are functionally associated with endocrine dysregulation. The interacting role of overweight body habitus and obesity in youth with BSD further indicates leptin resistance to be a central moderator of the dynamic neurobiology of BSD in youth. The intent of this mini-review is to advance our knowledge of youth BSD as multisystemic disorders with important contributions from endocrinology and immunology based on a developmental perspective. This knowledge can influence current clinical care and more importantly inform future research.

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Depression, body mass index, and chronic obstructive pulmonary disease – a holistic approach

Cited by 8 publications

References 49 publications

Does pulmonary rehabilitation alleviate depression in older patients with chronic obstructive pulmonary disease

Does pulmonary rehabilitation alleviate depression in older patients with chronic obstructive pulmonary disease

Alteration of the irisin–brain-derived neurotrophic factor axis contributes to disturbance of mood in COPD patients

Bipolar Spectrum Disorders in Male Youth: The Interplay between Symptom Severity, Inflammation, Steroid Secretion, and Body Composition

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Depression, body mass index, and chronic obstructive pulmonary disease &ndash; a holistic approach

Cited by 8 publications

References 49 publications

Does pulmonary rehabilitation alleviate depression in older patients with chronic obstructive pulmonary disease

Does pulmonary rehabilitation alleviate depression in older patients with chronic obstructive pulmonary disease

Alteration of the irisin&ndash;brain-derived neurotrophic factor axis contributes to disturbance of mood in COPD patients

Bipolar Spectrum Disorders in Male Youth: The Interplay between Symptom Severity, Inflammation, Steroid Secretion, and Body Composition

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Depression, body mass index, and chronic obstructive pulmonary disease – a holistic approach

Alteration of the irisin–brain-derived neurotrophic factor axis contributes to disturbance of mood in COPD patients