Depression following traumatic brain injury

Rosenthal, Mitchell; Christensen, Bruce K.; Ross, Thomas P.

doi:10.1016/s0003-9993(98)90215-5

Cited by 233 publications

(117 citation statements)

References 81 publications

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“…These events are rites of passage that have traditionally marked the transition from adolescence to adulthood in western society (Erikson, 1950;Levinson, 1978). Males who, as a result of TBI, cannot achieve these rites of passage, report feeling a sense of lost male adulthood, or gender role strain (Gutman and Napier-Klemic, 1996;Gutman, 1997Gutman, , 1998Hernandez et al, 1997;Rosenthal et al, 1998).…”

Section: Treatment Guidelinesmentioning

confidence: 99%

“…In western society -as in most cultures -adulthood is a status to be achieved (Grimes, 1995). When males who sustain TBI cannot achieve the rites of passage that are commonly accepted as indicators of adulthood in the larger society, they report feeling a lowered societal status (Gutman, 1998;Rosenthal et al, 1998). This lowered societal status is often reflected in their rehabilitation services -particularly long-term residential care facilities that often assume a parental guardian role (Tridon et al, 1983;Gutman, 1998).…”

mentioning

confidence: 99%

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The transition through adult rites of passage after traumatic brain injury: preliminary assessment of an occupational therapy intervention

Gutman

1999

Occupation Therapy Intl

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Section: Treatment Guidelinesmentioning

confidence: 99%

mentioning

confidence: 99%

The transition through adult rites of passage after traumatic brain injury: preliminary assessment of an occupational therapy intervention

Gutman

1999

Occupation Therapy Intl

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“…Other signs and symptoms include headaches, fatigue, and sleep disturbances. In addition, secondary neurologic disorders such as mood disorders and post-traumatic epilepsy can occur following TBI and disrupt health-related quality of life (Rosenthal, Christensen, and Ross, 1998;Hart, Brenner, Clark, Bogner, Novack, Chervoneva, NkaseRichardson, and Arango-Lasprilla, 2011;Lowenstein, 2009;Agrawal, Timothy, Pandit, and Manju, 2006). The scientific literature also suggests that TBI increases the risk for neurodegenerative disorders, such as dementia.…”

Section: Tbi Health Effectsmentioning

confidence: 99%

Prospective study of myelin water fraction changes after mild traumatic brain injury in collegiate contact sports

Spader

Dean

LaFrance

et al. 2019

Journal of Neurosurgery

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OBJECTIVEMild traumatic brain injury (mTBI) in athletes, including concussion, is increasingly being found to have long-term sequelae. Current imaging techniques have not been able to identify early damage caused by mTBI that is predictive of long-term symptoms or chronic traumatic encephalopathy. In this preliminary feasibility study, the authors investigated the use of an emerging magnetic resonance imaging (MRI) technique, multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT), in visualizing acute and chronic white matter changes after mTBI in collegiate football and rugby players.METHODSThis study was a nonrandomized, nonblinded prospective trial designed to quantify changes in the myelin water fraction (MWF), used as a surrogate MRI measure of myelin content, in a group of male collegiate football and rugby players, classified here as a contact sport player (CSP) cohort, at the time of mTBI diagnosis and 3 months after injury when the acute symptoms of the injury had resolved. In addition, differences in the MWF between the CSP cohort and a control cohort of noncontact sport players (NCSPs) were quantified. T-tests and a threshold-free cluster enhancement (TFCE) statistical analysis technique were used to identify brain structures with significant changes in the MWF between the CSP and NCSP cohorts and between immediately postinjury and follow-up images obtained in the CSP cohort.RESULTSBrain MR images of 12 right-handed male CSPs were analyzed and compared with brain images of 10 right-handed male NCSPs from the same institution. A comparison of CSP and NCSP baseline images using TFCE showed significantly higher MWFs in the bilateral basal ganglia, anterior and posterior corpora callosa, left corticospinal tract, and left anterior and superior temporal lobe (p < 0.05). At the 3-month follow-up examination, images from the CSP cohort still showed significantly higher MWFs than those identified on baseline images from the NCSP cohort in the bilateral basal ganglia, anterior and posterior corpora callosa, and left anterior temporal lobe, and also in the bilateral corticospinal tracts, parahippocampal gyrus, and bilateral juxtapositional (previously known as supplemental motor) areas (p < 0.05). In the CSP cohort, a t-test comparing the MWF at the time of injury and 3 months later showed a significant increase in the overall MWF at follow-up (p < 0.005). These increases were greatest in the bilateral basal ganglia and deep white matter. MWF decreases were seen in more superficial white matter (p < 0.005).CONCLUSIONSIn this preliminary study, MWF was found to be increased in the brains of CSPs compared with the brains of controls, suggesting acute/chronic MWF alterations in CSPs from previous injuries. Increases in the MWF were also demonstrated in the brains of CSPs 3 months after the players sustained an mTBI. The full clinical significance of an increased MWF and whether this reflects axon neuropathology or disorderly remyelination leading to hypermyelination has yet to be determined.

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“…As a result, treatment goals to reestablish meaningful social and occupational roles are compromised. Theories attempting to explain the nature of the relationship between TBI and depression include pre-existing depression, pre-injury personality type, social integration after injury, family support, neurochemical imbalances, and site of anatomical damage (Jean-Bay, 2000;Rosenthal, et al, 1998;Ownsworth and Oei, 1998). A review of the research by Rice, et al (1980) indicated that people who are satisfied with work also tend to be satisfied with other domains of life and with life as a whole.…”

Section: Satisfaction With Life Following Tbimentioning

confidence: 99%

The Impact of Intensive Community Based Rehabilitation on Community Participation and Life Satisfaction Following Severe Traumatic Brain Injury

Wheeler¹

2012

Brain Injury - Functional Aspects, Rehabilitation and Prevention

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Depression following traumatic brain injury

Cited by 233 publications

References 81 publications

The transition through adult rites of passage after traumatic brain injury: preliminary assessment of an occupational therapy intervention

The transition through adult rites of passage after traumatic brain injury: preliminary assessment of an occupational therapy intervention

Prospective study of myelin water fraction changes after mild traumatic brain injury in collegiate contact sports

The Impact of Intensive Community Based Rehabilitation on Community Participation and Life Satisfaction Following Severe Traumatic Brain Injury

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