Depression in Adolescents: Current Treatments, Suicidality and Evaluation of Novel Treatment Strategies

Smajkic, Amer

doi:10.17305/bjbms.2009.2768

Cited by 4 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Transcranial magnetic stimulation represents a non-invasive, feasible, effective, and safe treatment option for depression (55). There are no published reports that TMS increases suicide risk (56). However, there is only relatively few systematic research about the effect of rTMS on suicidality.…”

Section: Discussionmentioning

confidence: 99%

Anti-Suicidal Efficacy of Repetitive Transcranial Magnetic Stimulation in Depressive Patients: A Retrospective Analysis of a Large Sample

et al. 2020

View full text Add to dashboard Cite

Background: Suicide is a major public health problem. About 90% of suicide victims have one or more major psychiatric disorder, with a reported 20-fold increased risk for suicide in patients with affective disorders in comparison with healthy subjects. Repetitive transcranial magnetic stimulation (rTMS) has been established as an effective alternative or adjunctive treatment option for patients with depressive disorders, but little is known about its effects on suicide risk. Objective: For the assessment of the effectiveness of rTMS on suicidal ideation and behaviors, we performed a retrospective analysis of a large sample of patients with depressive disorders, who were treated with rTMS. Methods: We analyzed the records of 711 TMS in-and outpatients with depressive affective disorders in a tertiary referral hospital between 2002 and 2017. Out of these patients we were able to collect Hamilton depression rating scale (HAMD) data of 332 patients (180 females, 152 males; age range 20 to 79 years; mean age 47.3 ± 12.3) for which we analyzed the change of suicidal ideation by using item 3 (suicidality) of HAMD. Results: Out of all 711 patients treated with rTMS for their depression, one patient (0.1%) committed suicide during the TMS treatment. In the statistical analysis of the subsample with 332 patients there was an overall amelioration of depressive symptoms accompanied by a significant decrease in the suicidality item with a medium effect size. Decrease in suicidality was not inferior to changes in other items as indicated by effect sizes. Fortyseven percent of patients showed an amelioration in suicidality, 41.3% of patients did not show a change in their suicidality's scores, and 11.7% of patients showed an increase in suicidality's scores from baseline to final rating. Correlation of item 3 (suicidality) and item 7 (drive) demonstrated a significant positive association, revealing improved drive with a parallel decreased suicidality. Conclusion: Based on the proposed data, there is no evidence that rTMS increases the risk for suicide during the course of the treatment. Conversely, rTMS tends to reduce

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-Suicidal Efficacy of Repetitive Transcranial Magnetic Stimulation in Depressive Patients: A Retrospective Analysis of a Large Sample

et al. 2020

View full text Add to dashboard Cite

show abstract

“…There are many reasons for low rates of ECT for children and adolescents including fears related to the potential deleterious influence of the procedure on the human brain and in particular the developing brain. 8 Thus, according to published reports, only 1.5% (and less in most countries) of all ECT treatments are given to patients younger than 20 years. 9 Studies indicate that most child and adolescent psychiatrists lack sufficient education and training regarding ECT.…”

mentioning

confidence: 99%

“…The conclusions drawn by Rey and Walter 7 have received some criticism afterward as improvement rates for different diagnoses cannot be accurately measured because many studies did not report diagnosis. There are many reasons for low rates of ECT for children and adolescents including fears related to the potential deleterious influence of the procedure on the human brain and in particular the developing brain 8 . Thus, according to published reports, only 1.5% (and less in most countries) of all ECT treatments are given to patients younger than 20 years 9 .…”

mentioning

confidence: 99%

Electroconvulsive Therapy in Children and Adolescents

Døssing

Pagsberg

2021

J ECT

View full text Add to dashboard Cite

There is a lack of studies regarding the efficacy of electroconvulsive therapy (ECT) in children and adolescents. In this study, we aimed to assess benefits and harms of ECT in children and adolescents with major psychiatric diseases. We conducted a systematic search in PubMed, EMBASE, and PsycINFO for peer-reviewed articles written in English regarding the use of ECT as treatment for major psychiatric diseases in children and adolescents. This study consists of 192 articles, mostly case studies (n = 50), reviews and overview articles (n = 52), and retrospective studies (n = 30). We present an overview of evidence for ECT in children and adolescents with mood disorders, catatonia, schizophrenia, intellectual disability, self-injurious behavior, and other indications. This article is also a summary of international guidelines regarding the use of ECT in children and adolescents. We evaluated the overall quality of evidence by using Grading of Recommendations, Assessment, Development and Evaluations and found the overall level of evidence to be of low quality. There are no absolute contra indications for ECT in children and adolescents. Fears regarding cognitive dysfunction have not been reproduced in studies. Electroconvulsive therapy should be considered in severe, treatment-resistant mood disorders, catatonia, and schizophrenia, especially in older adolescents. High-quality studies are warranted to assess the efficacy of ECT, especially in these potentially life-threatening diseases.

show abstract

“…Therefore, there is a need for a more detailed evaluation of its efficient application in the pediatric population [37].…”

Section: Limitations Of Existing Studiesmentioning

confidence: 99%

Safety and Efficacy of Transcranial Magnetic Stimulation (TMS) in Pediatric Depression

Gupta¹,

Singh²,

Gupta³

et al. 2021

Journal of Indian Association for Child and Adolescent Mental H

View full text Add to dashboard Cite

Depression in Adolescents: Current Treatments, Suicidality and Evaluation of Novel Treatment Strategies

Cited by 4 publications

References 30 publications

Anti-Suicidal Efficacy of Repetitive Transcranial Magnetic Stimulation in Depressive Patients: A Retrospective Analysis of a Large Sample

Anti-Suicidal Efficacy of Repetitive Transcranial Magnetic Stimulation in Depressive Patients: A Retrospective Analysis of a Large Sample

Electroconvulsive Therapy in Children and Adolescents

Safety and Efficacy of Transcranial Magnetic Stimulation (TMS) in Pediatric Depression

Contact Info

Product

Resources

About