Depression in Alzheimer’s Disease: Epidemiology, Mechanisms, and Treatment

Huang, Yu-Yuan; Gan, Yi-Han; Yang, Liu; Cheng, Wei; Yu, Jin-Tai

doi:10.1016/j.biopsych.2023.10.008

Cited by 18 publications

(2 citation statements)

References 125 publications

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“…It is well-established that aberrant splicing and metabolism of the APP, leading to the production of beta-amyloid, constitutes the critical pathological basis for Alzheimer’s disease. An accumulating body of evidence suggests the existence of a shared genetic foundation between MDD and Alzheimer’s disease [ 38 , 39 ]. These findings illustrate that APP also plays a pivotal role in the pathogenic mechanisms underlying depressive disorders.…”

Section: Discussionmentioning

confidence: 99%

Mining key circadian biomarkers for major depressive disorder by integrating bioinformatics and machine learning

Shi,

Zhu,

Hou

et al. 2024

Aging

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Section: Discussionmentioning

confidence: 99%

Mining key circadian biomarkers for major depressive disorder by integrating bioinformatics and machine learning

Shi,

Zhu,

Hou

et al. 2024

Aging

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“…Alzheimer’s disease (AD) is the prevailing form of dementia, primarily distinguished by three prominent syndromes: diminished cognitive function [ 1, 2 ], impaired daily living capacity [ 3 ], and mental behavioral abnormalities [ 4 ]. These manifestations significantly impact the physical and mental well-being as well as the overall quality of life experienced by affected individuals.…”

Section: Introductionmentioning

confidence: 99%

Visualization of Microcirculation at Acupoints in vivo of Alzheimer’s Disease Animal Model with Photoacoustic Microscope: A Pilot Study

Jiang,

Wang,

et al. 2024

Journal of Alzheimer's Disease Reports

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Background: Alzheimer’s disease may be effectively treated with acupoint-based acupuncture, which is acknowledged globally. However, more research is needed to understand the alterations in acupoints that occur throughout the illness and acupuncture treatment. Objective: This research investigated the differences in acupoint microcirculation between normal mice and AD animals in vivo. This research also examined how acupuncture affected AD animal models and acupoint microcirculation. Methods: 6-month-old SAMP8 mice were divided into two groups: the AD group and the acupuncture group. Additionally, SAMR1 mice of the same month were included as the normal group. The study involved subjecting a group of mice to 28 consecutive days of acupuncture at the ST36 (Zusanli) and CV12 (Zhongwan) acupoints. Following this treatment, the Morris water maze test was conducted to assess the mice’s learning and memory abilities; the acoustic-resolution photoacoustic microscope (AR-PAM) imaging system was utilized to observe the microcirculation in CV12 acupoint region and head-specific region of each group of mice. Results: In comparison to the control group, the mice in the AD group exhibited a considerable decline in their learning and memory capabilities (p < 0.01). In comparison to the control group, the vascular in the CV12 region and head-specific region in mice from the AD group exhibited a considerable reduction in length, distance, and diameter r (p < 0.01). The implementation of acupuncture treatment had the potential to enhance the aforementioned condition to a certain degree. Conclusions: These findings offered tangible visual evidence that supports the ongoing investigation into the underlying mechanisms of acupuncture’s therapeutic effects.

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