Depression in amyotrophic lateral sclerosis

Atassi, Nazem; Cook, Amanda; Pineda, Cristiana M.; Yerramilli-Rao, Padmaja; Pulley, Darlene; Cudkowicz, Merit

doi:10.3109/17482968.2010.536839

Cited by 84 publications

(85 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…23,24 Patients with ALS may be prescribed with antidepressants for reasons other than depression, such as excessive salivation where the anticholinergic side effect of antidepressants is desirable and emotional outbursts where the patients suddenly and without control cry or laugh. These possibilities likely explain the more pronounced risk increase for antidepressant use after ALS diagnosis, compared to depression diagnosis, as observed in the present study.…”

Section: Discussionmentioning

confidence: 99%

Depression in amyotrophic lateral sclerosis

et al. 2016

View full text Add to dashboard Cite

Objective: To examine the relative risk of depression among patients with amyotrophic lateral sclerosis (ALS), both in terms of depression diagnosis and use of antidepressant drugs, before and after diagnosis. Methods:We conducted a nested case-control study including 1,752 patients with ALS diagnosed from July 2005 to December 2010 and 8,760 controls based on the Swedish national health and population registers, to assess the associations of depression diagnosis and use of antidepressant drugs with a subsequent risk of ALS. We further followed the patients with ALS after diagnosis to estimate the association of an ALS diagnosis with the subsequent risk of depression and use of antidepressant drugs.Results: Before diagnosis, patients with ALS were at higher risk of receiving a clinical diagnosis of depression compared to controls (odds ratio [OR] 1.7, 95% confidence interval [CI] 1.3-2.3), and the highest risk increase was noted during the year before diagnosis (OR 3.5, 95% CI 2.1-5.6). Patients with ALS also had a highly increased risk of depression within the first year after diagnosis (hazard ratio 7.9, 95% CI 4.4-14.3). Antidepressant use was more common in patients with ALS than in controls, especially during the year before (OR 5.8, 95% CI 4.5-7.5) and the year after (hazard ratio 16.1, 95% CI 11.5-22.6) diagnosis. Approximately 30% of patients with amyotrophic lateral sclerosis (ALS) show mild cognitive impairment and 15% present with overt frontotemporal dementia (FTD). Conclusions:1,2 The overlap between ALS and FTD presents a continuum of symptoms such as memory impairment, apathy, and behavioral changes, 3,4 many of which mimic the typical symptoms of depression. 5The strong emotions evoked by receiving a serious diagnosis such as ALS may also lead to increased risk of mental illnesses, including depression. Multiple studies have shown that patients with ALS are more likely to develop depression than ALS-free individuals, although the reported prevalence of depression varies greatly.6-13 Different measurements of depression together with the varying representativeness of the patient samples used in previous studies may partly explain the different prevalences reported so far.The aim of the present study was to investigate the occurrence of depression diagnosis and use of antidepressants before and after ALS diagnosis in a nationwide sample of patients with ALS, using a matched random sample of the Swedish population as the reference.

show abstract

Section: Discussionmentioning

confidence: 99%

Depression in amyotrophic lateral sclerosis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…However, the reductionism of Combe's distinction clearly emerges from the clinical observation given that a wide range of nervous system's illnesses with different etiology shows both neurological and psychiatric symptoms. Emotional and behavioral disturbances with a polymorphic symptomatology are often connected to neurological disorders such as Multiple Sclerosis (MS) [1][2][3] , Parkinson' s Disease (PD) [4] , stroke [5] , dementia [6] , traumatic brain injury [7] , epilepsy [8,9] , Amyotrophic Lateral Sclerosis (ALS) and others Motor Neuron Diseases (MND) [10,11] , pain syndromes (like headaches) and can be observed even with or without "organic" neurological diseases, thus miming in some cases an idiopathic psychiatric disorder.…”

Section: Neurology and Psychiatrymentioning

confidence: 99%

Effects of music and music therapy on mood in neurological patients

Raglio

Attardo

Gontero

et al. 2015

WJP

164

View full text Add to dashboard Cite

Mood disorder and depressive syndromes represent a common comorbid condition in neurological disorders with a prevalence rate that ranges between 20% and 50% of patients with stroke, epilepsy, multiple sclerosis, and Parkinson's disease. Notwithstanding, these conditions are often under-diagnosed and under-treated in the clinical practice and negatively affect the functional recovery, the adherence to treatment, the quality of life, and even the mortality risk. In addition, a bidirectional association between depression and neurological disorders may be possible being that depressive syndromes may be considered as a risk factor for certain neurological diseases. Despite the large amount of evidence regarding the effects of music therapy (MT) and other musical interventions on different aspects of neurological disorders, no updated article reviewing outcomes such as mood, emotions, depression, activity of daily living and so on is actually available; for this reason, little is known about the effectiveness of music and MT on these important outcomes in neurological patients. The aim of this article is to provide a narrative review of the current literature on musical interventions and their effects on mood and depression in patients with neurological disorders. Searching on PubMed and PsycInfo databases, 25 studies corresponding to the inclusion criteria have been selected; 11 of them assess the effects of music or MT in Dementia, 9 explore the efficacy on patients with Stroke, and 5 regard other neurological diseases like Multiple Sclerosis, Amyotrophic Lateral Sclerosis/motor neuron disease, Chronic quadriplegia, Parkinson's Disease, and Acquired Brain dysfunctions. Selected studies are based on relational and rehabilitative music therapy approaches or concern music listening interventions. Most of the studies support the efficacy of MT and other musical interventions on mood, depressive syndromes, and quality of life on neurological patients.

show abstract

“…Systematic reviews concluded that major depression is uncommon, affecting between 6 and 12% of patients [12,13]. Recent studies report estimates of 6% for major and 29% for mild depression [14], of 22% for major and minor depression altogether [15]. In 13.5% of patients depression followed ALS diagnosis [16] and in 20% an antidepressant treatment preceded ALS [17].…”

Section: Introductionmentioning

confidence: 99%

“…The relation with the site of onset [14,18], gender [14,18,19], time since diagnosis [14,17,19,20] and physical impairment [14,15,18,21] is also controversial. Methodological problems, including small sample size and cross-sectional design, partly explain these inconsistencies.…”

Section: Introductionmentioning

confidence: 99%

The Use of Antidepressant Medication before and after the Diagnosis of Amyotrophic Lateral Sclerosis: A Population-Based Cohort Study

et al. 2015

View full text Add to dashboard Cite

Background: The prevalent use of antidepressants (ATDs) in patients with Amyotrophic Lateral Sclerosis (ALS) varies across cross-sectional and clinic-based published studies. This population-based cohort study assesses the real-world prevalence of the use of ATDs, its trajectory and the association of incident use with clinical characteristics. Methods: All patients with incident ALS in the Friuli Venezia Giulia region, Italy, from 2002 to 2009, were identified through multiple sources including health databases. Diagnosis was validated through clinical documentation review. ATDs prescriptions from 2000 to 2011 were obtained from regional database. The trajectory was estimated through generalized estimating equations for repeated measures logistic regression and the Hazard ratio (HR) of initiating ATDs through multivariate proportional hazard Cox regression. Results: In this cohort of 261 ALS cases, age-, sex-adjusted prevalence of the use of ATDs was 37.3%, higher than in general population. The trajectory increased by 16% in 1-year period across diagnosis. Age ≤67 years at diagnosis (HR 1.28, 95% CI 0.84-1.95) and bulbar onset (1.43, 95% CI 0.90-2.26) were positively associated with initiating ATDs after diagnosis. Conclusions: More than one-third of patients used ATDs. Depression may occur more frequently than previously reported. Depression may precede motor alterations and be related to both ALS diagnosis and progression.

show abstract

Depression in amyotrophic lateral sclerosis

Cited by 84 publications

References 17 publications

Depression in amyotrophic lateral sclerosis

Depression in amyotrophic lateral sclerosis

Effects of music and music therapy on mood in neurological patients

The Use of Antidepressant Medication before and after the Diagnosis of Amyotrophic Lateral Sclerosis: A Population-Based Cohort Study

Contact Info

Product

Resources

About