Depression in Association With Severe Obesity

Dixon, John; Dixon, Maureen Elizabeth; O'Brien, Paul Edmond

doi:10.1001/archinte.163.17.2058

Cited by 447 publications

(332 citation statements)

References 52 publications

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“…It has been pointed out that depression should be considered another comorbidity of obesity. 38 In the present study, high rates of depression cases were observed in both treatment groups before treatment. The estimated The SOS study: 10-year follow-up of quality of life J Karlsson et al prevalence according to the HAD depression scale was 2.7 and 4 times higher, respectively, in the conventional and surgical group than in the nonobese reference population.…”

Section: Discussionsupporting

confidence: 51%

“…In a prospective study, Beck Depression Inventory (BDI) was used to assess symptoms of depression in patients at yearly intervals up to 4 years after gastric banding. 38 High scores before treatment decreased with about one-half during the first year postsurgically and most of the positive effect remained in patients available for follow-up after 4 years; however, mean scores tended to increase between 1 and 4 years. In line with the present study, greater weight loss was associated with greater reduction of depression symptoms.…”

Section: Discussionmentioning

confidence: 90%

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Ten-year trends in health-related quality of life after surgical and conventional treatment for severe obesity: the SOS intervention study

et al. 2007

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Objective: To examine trends and effects of weight loss treatment on health-related quality of life (HRQL) in the severely obese over 10 years. Design: Swedish obese subjects (SOS) intervention study is a controlled, longitudinal trial of the health effects of weight loss in the severely obese. Subjects: A total of 655 of 851 surgically treated and 621 of 852 conventionally treated obese men (body mass index, BMIX34) and women (BMIX38) who completed 10 years of the study. Measurements: HRQL was assessed before treatment and after 0.5, 1, 2, 3, 4, 6, 8 and 10 years. Results: HRQL change during the 10-year observation period largely followed phases of weight loss, weight regain and weight stability. Improvements and deteriorations in HRQL were associated with the magnitude of weight loss or regain, except regarding anxiety. Peak improvements in the surgical group were observed during the first year of weight loss, whereas the weight regain phase (mainly between 1-and 6-year follow-up) was accompanied by a gradual decline in HRQL. The period from 6-to 10-year follow-up was characterized by relatively stable observations in both weight and HRQL. At 10 years, net gains were noted in all HRQL domains compared to baseline. Comparisons of treatment effects on HRQL in the surgical vs conventional group after 10 years showed significantly better outcome in the surgical group on current health perceptions, social interaction, psychosocial functioning and depression, whereas no significant differences were found for overall mood and anxiety. Long-term results of the study suggest that a maintained weight loss of about 10% is sufficient for positive long-term effects on HRQL, a limit that was reached in about two-thirds of the surgically treated patients who completed 10 years of the study. Conclusion: Long-lasting weight reduction in the severely obese has a general long-standing positive outcome on HRQL. Bariatric surgery is a favorable option for the treatment of severe obesity, resulting in long-term weight loss and HRQL improvements in a majority of patients. However, difficulties among some surgical patients to control and maintain weight loss over time should not be ignored. Future research should study if the long-term efficacy of bariatric surgery may be further enhanced by implementing lifestyle modification techniques in the postoperative management of patients.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 90%

Ten-year trends in health-related quality of life after surgical and conventional treatment for severe obesity: the SOS intervention study

et al. 2007

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“…Additional support for a causal pathway from obesity to psychiatric disturbance, most notably depression, comes from research on change in psychopathologic features among obese individuals as a function of weight loss after behavioral, dietary 18,19 or surgical 20,21 intervention. For example, Dixon et al 20 reported a significant and sustained drop in scores on the Beck Depression Inventory from 17.779.5 at baseline to 7.876.5 and 9.677.7 1 and 4 years later, respectively, following gastric-restrictive weight loss surgery. Nonetheless, obese individuals who enter weight reduction programs are reported to be more depressed or more anxious than obese individuals in the general population, and thus may be more likely to experience a decline in symptoms with weight loss.…”

Section: Introductionmentioning

confidence: 99%

Obesity and psychopathology in women: a three decade prospective study

et al. 2007

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Objective: To evaluate prospective associations between elevations in body mass index (BMI) at average age 27 and generalized anxiety disorder (GAD) and major depressive disorder (MDD) at average age 59 in a community sample of women. Design: Three waves of data collected over three decades were drawn from mothers in the Children in the Community (CIC) Study. Binary logistic regression was used to estimate predictive effects of two BMI cutpoints (X30 and X25) on GAD and MDD independent of other risks for psychopathology. Measurements: Information about height and weight was obtained by self-report in face-to-face interviews. GAD and MDD were assessed by structured interview covering DSM-IV diagnostic criteria. Other potential risk factors examined included age, race, education, prior depressive symptoms and marital status, chronic disease, social support and financial strain concurrent with GAD and MDD. Results: A baseline BMI X30 significantly increased the odds for subsequent GAD and MDD by 6.27 and 5.25 times, respectively, after adjusting for other significant risk factors. Odds of GAD also increased significantly given a baseline BMI X25 (by 2.44 times); however this association was not independent of other significant risk factors. Predictive associations between a baseline BMI X30 and MDD were not attenuated by attained BMI assessed at outcome. Conclusion: Findings extend existing evidence of the mental health consequences of obesity in a representative sample of mothers, and suggest that obesity may have long-term implications for mental distress in women at a clinical level over the adult years.

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“…A obesidade é a doença física mais comum e crônica na sociedade moderna e a depressão é a condição psicológica mais prevalente. Embora haja alta prevalência para essas duas condições, a exploração de qualquer associação entre elas tem sido limitada 6 .…”

Section: N T R O D U ç ã Ounclassified

Antidepressivos e alterações no peso corporal

et al. 2008

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A depressão é uma doença que pode levar a mudanças no peso, influenciadas por fatores específicos da doença, como alterações no apetite e na atividade física, ou pelos antidepressivos. Este artigo objetiva analisar os estudos que descrevem os efeitos dos antidepressivos em alterações do peso corporal. Realizou-se uma pesquisa nas bases de dados Medline, Lilacs e Cochrane, utilizando as palavras chaves "antidepressivo" e "peso". Foram selecionados os estudos que analisaram o tema em pacientes depressivos, priorizando-se aqueles relacionados às drogas mais utilizadas nos serviços de saúde no Brasil. A análise dos estudos indicou que a mudança de peso atribuída ao tratamento com antidepressivos apresenta resultados ainda controversos, sendo influenciada por fatores como o tempo de uso e a dosagem do medicamento, estudos com poder limitado, entre outros. Assim, estudos com maior poder, tendo como foco a ação das drogas antidepressivas nas alterações do peso corporal em pacientes depressivos, ainda são necessários. Termos de indexação:Antidepressivos. Ganho/Perda de peso. Peso corporal. A B S T R A C T Depression is a disorder that may affect patient's weight because of specific factors of the disease, such as changes in appetite and

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Depression in Association With Severe Obesity

Abstract: Severely obese subjects, especially younger women with poor body image, are at high risk for depression. We found sustained improvement with weight loss. These findings also support the hypothesis that severe obesity causes or aggravates depression.

Cited by 447 publications

References 52 publications

Ten-year trends in health-related quality of life after surgical and conventional treatment for severe obesity: the SOS intervention study

Ten-year trends in health-related quality of life after surgical and conventional treatment for severe obesity: the SOS intervention study

Obesity and psychopathology in women: a three decade prospective study

Antidepressivos e alterações no peso corporal

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