Depression in Dercum’s disease and in obesity: A case control study

Hansson, Emma; Svensson, Henry; Brorson, Håkan

doi:10.1186/1471-244x-12-74

Cited by 13 publications

(10 citation statements)

References 16 publications

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“…A case control study on depression in Dercum’s disease was published by Hansson et al [15]. They investigated 111 women with the disease and applied the Montgomery Åsberg Depression Rating Scale.…”

Section: Clinical Presentationmentioning

confidence: 99%

Dercum’s disease (adiposis dolorosa): a review of clinical presentation and management

Kucharz¹,

Kopeć-Mędrek²,

Kramza³

et al. 2019

Reumatologia

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Dercum's disease (adiposis dolorosa) is a rare disease of unknown etiology characterized by painful subcutaneous adipose tissue deposits with various localization over the body. The deposits occur histologically as lipomas and are associated with overweight or obesity and a variety of psychiatric disturbances (anxiety, depression, sleep disturbances). Classification of Dercum's disease is related to size and location of adipose nodules (generalized diffuse, generalized nodular, localized nodular and juxta-articular forms). Diagnosis in based on clinical presentation and exclusion of a number of other disorders associated with lipomas. There is no generally accepted management of the patients. Liposuction or lidocaine application has been reported successful in some cases. Other therapeutic methods have been reported but their effectiveness is based on anecdotal descriptions only, and were not confirmed in clinical trials.

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Section: Clinical Presentationmentioning

confidence: 99%

Dercum’s disease (adiposis dolorosa): a review of clinical presentation and management

Kucharz¹,

Kopeć-Mędrek²,

Kramza³

et al. 2019

Reumatologia

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“…Accompanying signs such as vascular fragility (ecchymotic tendency) and neuropsychic disorders (anxiety, sleep disorders, memory impairment, and depression (as seen in 55% of a series of 111 women with Dercum’s disease [ 28 ])) are frequent. Less specific disorders such as digestive symptoms (constipation, bloating, and chronic abdominal pain), tachycardia, shortness of breath, asthenia, generalized muscle weakness, arthralgia [ 29 ], and repeated infections (vaginitis) have been reported.…”

Section: Dercum’s Diseasementioning

confidence: 99%

“…Modulation of the neuropeptides involved in the pain signal was demonstrated in the serum and cerebrospinal fluid (CSF) of 53 DD patients with respect to substance P, neuropeptide Y, and ß-endorphin. In the CSF, substance P and neuropeptide Y levels were lower, and the ß-endorphin level was higher than in the obese control group [ 28 ]. Of note is that these three substances are involved in food intake and are associated with obesity [ 39 , 40 ].…”

Section: Dercum’s Diseasementioning

confidence: 99%

Rare Forms of Lipomatosis: Dercum’s Disease and Roch-Leri Mesosomatous Lipomatosis

Lemaître

Aubert

Chevalier³

et al. 2021

JCM

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In contrast to obesity, which is very frequent, lipomatosis and lipodystrophy syndromes are rare diseases of adipose tissue. Lipodystrophy syndromes are characterized by metabolic abnormalities associated with partial or generalized lipoatrophy. Lipomatosis is defined by the presence of several body lipomas without lipoatrophy. Dercum’s disease (DD) and Roch-Leri mesosomatous lipomatosis (RLML) are rare and poorly characterized forms of lipomatosis. They have raised little clinical interest despite the non-negligible consequences of DD on quality of life. The main clinical presentation of these diseases includes multiple lipomas, which are painful in DD (in contrast to RLML). The two diseases are frequently associated with obesity and metabolic syndrome, with hypertension, diabetes, or dyslipidemia. The long-term course of the diseases remains poorly described. DD affects mainly women, whereas RLML mostly affects men. In both diseases lipomas are found on the back and thighs, as well as on the abdomen in DD and the forearms in RLML. The painful lipomas tend to recur after surgery in DD (in contrast to RLML). Most cases are sporadic. No specific treatment has been identified, as the pathophysiology remains unknown. Nevertheless, low-grade fat inflammation and specific abnormalities such as hyperbasophilia deserve further investigation. The aim of this review is to analyze the available literature on the topic.

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“…Depression was observed in 55 % of 111 patients with lipomatosis dolorosa, so that psychiatric co‐treatment is often advisable .…”

Section: Lipomatosis Dolorosa (Dercum's Disease)mentioning

confidence: 99%

Lipomatoses

Ghazal

Grönemeyer

Schön

2018

J Deutsche Derma Gesell

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Lipomatoses are benign proliferations of adipose tissue, often with typical distribution patterns, which usually occur without clear causes. In contrast to circumscribed lipomas, they develop diffusely and symmetrically and are not surrounded by a fibrous pseudocapsule. The most common form is benign symmetric lipomatosis (BSL; Launois-Bensaude syndrome), of which four types are distinguished based on the distribution pattern of hyperplastic adipose tissue. The etiology and pathogenesis of the disease are still largely unknown, although some forms appear to have a hereditary basis or to be associated with increased alcohol consumption. In some cases, mitochondrial dysfunctions have been detected. Lipomatoses may be solitary, but may also be associated with other symptoms or illnesses (comorbidity). Effective drug therapies are not known, but surgical procedures can alleviate the symptoms. Lipomatosis dolorosa, which can be distinguished from BSL, occurs predominantly in middle-aged women and is characterized by proliferation of adipose tissue and severe pain in the affected areas. Various differential diagnoses and concomitant illnesses need to be considered, in particular depression. There are no evidence-based recommendations for therapy. Repetitive lidocaine infusions can achieve temporary improvement. Recurrence after surgical intervention is not uncommon, but long-term success is also possible.

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Depression in Dercum’s disease and in obesity: A case control study

Cited by 13 publications

References 16 publications

Dercum’s disease (adiposis dolorosa): a review of clinical presentation and management

Dercum’s disease (adiposis dolorosa): a review of clinical presentation and management

Rare Forms of Lipomatosis: Dercum’s Disease and Roch-Leri Mesosomatous Lipomatosis

Lipomatoses

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