Depression in heart failure: Intricate relationship, pathophysiology and most updated evidence of interventions from recent clinical studies

Ghosh, Raktim; Ball, Somedeb; Prasad, Vinita; Gupta, Anjan

doi:10.1016/j.ijcard.2016.09.063

Cited by 66 publications

(66 citation statements)

References 117 publications

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“…It has been suggested that biological and behavioral pathways appear to be involved in this relationship. For example, depression and heart failure share the dysregulation of the hypothalamus–pituitary–adrenal axis, inflammation, and oxidative stress 33. Similar mechanisms have been described for social isolation 34.…”

Section: Discussionmentioning

confidence: 83%

Role of Depression and Social Isolation at Time of Waitlisting for Survival 8 Years After Heart Transplantation

Spaderna

Zittermann

Reichenspurner

et al. 2017

JAHA

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BackgroundWe evaluated depression and social isolation assessed at time of waitlisting as predictors of survival in heart transplant (HTx) recipients.Methods and ResultsBetween 2005 and 2006, 318 adult HTx candidates were enrolled in the Waiting for a New Heart Study, and 164 received transplantation. Patients were followed until February 2013. Psychosocial characteristics were assessed by questionnaires. Eurotransplant provided medical data at waitlisting, transplantation dates, and donor characteristics; hospitals reported medical data at HTx and date of death after HTx. During a median follow‐up of 70 months (<1–93 months post‐HTx), 56 (38%) of 148 transplanted patients with complete data died. Depression scores were unrelated to social isolation, and neither correlated with disease severity. Higher depression scores increased the risk of dying (hazard ratio=1.07, 95% confidence interval, 1.01, 1.15, P=0.032), which was moderated by social isolation scores (significant interaction term; hazard ratio = 0.985, 95% confidence interval, 0.973, 0.998; P=0.022). These findings were maintained in multivariate models controlling for covariates (P values 0.020–0.039). Actuarial 1‐year/5‐year survival was best for patients with low depression who were not socially isolated at waitlisting (86% after 1 year, 79% after 5 years). Survival of those who were either depressed, or socially isolated or both, was lower, especially 5 years posttransplant (56%, 60%, and 62%, respectively).ConclusionsLow depression in conjunction with social integration at time of waitlisting is related to enhanced chances for survival after HTx. Both factors should be considered for inclusion in standardized assessments and interventions for HTx candidates.

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Section: Discussionmentioning

confidence: 83%

Role of Depression and Social Isolation at Time of Waitlisting for Survival 8 Years After Heart Transplantation

Spaderna

Zittermann

Reichenspurner

et al. 2017

JAHA

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“…Patients were identified as CHF patients if they exhibited a clinical syndrome characterized by typical symptoms (e.g., breathlessness, ankle swelling and fatigue) that may be accompanied by signs (e.g., elevated jugular venous pressure, pulmonary crackles and peripheral oedema) [18]. The aetiology of CHF in all patients was assessed by echocardiography, cineventriculography, a radionuclide technique, cardiac magnetic resonance and coronary angiography [12]. Among the 110 patients with CHF, 25 patients underwent cardiac surgery, including 12 patients who underwent coronary artery bypass grafting (CABG) and 13 patients who underwent valvular replacement.…”

Section: Methodsmentioning

confidence: 99%

“…Congestive heart failure (CHF) is a complex clinical syndrome that results from any structural or functional impairment of the ventricular filling or ejection of blood [12]. The renin-angiotensin-aldosterone system (RAAS) plays a critical role in the regulation of sodium and water balance and stimulates myocardial and vascular fibrosis in CHF [13].…”

Section: Introductionmentioning

confidence: 99%

Association Between C1q/TNF-Related Protein-1 Levels in Human Plasma and Epicardial Adipose Tissues and Congestive Heart Failure

Yang¹,

Liu

Zhang

et al. 2017

Cell Physiol Biochem

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Background/Aims: C1q and tumour necrosis factor-related protein 1 (CTRP1) possesses anti-atherogenic and anti-inflammatory effects. This study investigated whether the CTRP1 levels in the plasma and epicardial adipose tissue (EAT) were associated with congestive heart failure (CHF) and to disclose possible molecular mechanisms. Methods: Plasma and tissue samples were obtained from subjects with or without CHF. Plasma levels of CTRP1 were measured by ELISA. The mRNA levels of CTRP1 and inflammatory cytokines were detected by RT-PCR. The protein levels of CTRP1, aldosterone synthase (CYP11B2) and mitogen-activated protein kinase were examined by Western blotting. Results: The levels of CTRP1 in the plasma and EAT were higher in the CHF patients than those in the controls. There were no differences in the CTRP1 levels in cardiomyocytes between the CHF group and the non-CHF group. An exploratory survival analysis showed that higher CTRP1 values at admission were associated with a worse prognosis after discharge. CTRP1 increased the IL-6 mRNA level in H295R cells. CTRP1 recruited ERK1/2 and Jak-2 for aldosterone release by modulating the CYP11B2 protein level, and brain natriuretic peptide repressed the CTRP1-induced aldosterone release through the JAK2-STAT3 signalling pathways. Conclusion: The CTRP1 levels in the plasma and EAT were increased in the CHF patients. CTRP1 is involved in the pathogenesis of CHF by modulating IL-6 levels and aldosterone release.

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“…Como es posible esperar en pacientes con este perfil de severidad, se observó un alto porcentaje de pacientes con hospitalizaciones previas. Particularmente importante es la elevada prevalencia de síntomas depresivos y la baja calidad de vida autoreportada, la que es marcadamente peor a la observada en otros estudios que evalúan población de pacientes hospitalizados [14][15][16][17] . Una explicación posible de estos hallazgos puede ser la prevalencia de fragilidad concomitante en nuestra población, comparable con la de otros estudios 18 , la cual se presenta en pacientes con síntomas depresivos y, además, disminuye la calidad de vida, sin embargo, la implicancia de estos hallazgos debe ser analizada en futuros estudios.…”

Section: Discussionunclassified

Galectina-3: experiencia en pacientes chilenos con diagnóstico de insuficiencia cardíaca descompensada

et al. 2017

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Background: Galectin-3 (Gal-3) is a mediator of myocardial fibrosis involved in cardiac remodeling and a potential new prognosis marker in heart failure (HF respectively, p = 0.025) and were hypertensive in a higher proportion (90.5% and 57.1% respectively, p = 0.021). Conclusions: In patients hospitalized for HF, Gal-3 levels are higher in older and hypertensive subjects. (Rev Med Chile 2017; 145: 734-740)

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Depression in heart failure: Intricate relationship, pathophysiology and most updated evidence of interventions from recent clinical studies

Cited by 66 publications

References 117 publications

Role of Depression and Social Isolation at Time of Waitlisting for Survival 8 Years After Heart Transplantation

Role of Depression and Social Isolation at Time of Waitlisting for Survival 8 Years After Heart Transplantation

Association Between C1q/TNF-Related Protein-1 Levels in Human Plasma and Epicardial Adipose Tissues and Congestive Heart Failure

Galectina-3: experiencia en pacientes chilenos con diagnóstico de insuficiencia cardíaca descompensada

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