Depression in Later Life: An Overview with Treatment Recommendations

Ellison, James M.; Kyomen, Helen H.; Harper, David G.

doi:10.1016/j.psc.2012.01.003

Cited by 35 publications

(34 citation statements)

References 116 publications

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“…It has been also recently reported that LLD may result in increased risks of comorbidity [7], polypharmacy [8], frailty [9], and also all-cause mortality [10], thus becoming a major public health concern for the next future [1,11,12]. Despite these data, LLD is still under recognized in clinical practice, with less than 10 % of older subjects that have formal evaluation and treatment for this condition [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Klotho Gene and Selective Serotonin Reuptake Inhibitors: Response to Treatment in Late-Life Major Depressive Disorder

et al. 2016

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Klotho protein, encoded by the Klotho gene (KL) at locus 13q12, is an antiaging hormone-like protein playing a pivotal role in cell metabolism homeostasis and associated to longevity and age-related diseases. In particular, altered cell metabolism in central nervous system may influence the behavior of serotoninergic neurons. The role of KL in the response to treatment with selective serotonin reuptake inhibitors (SSRIs) in late-life depressive syndromes and late-life major depressive disorder (MDD) is unclear. We genotyped three single-nucleotide polymorphisms (SNPs) of KL in 329 older patients with diagnosis of late-life MDD, treated with SSRIs and evaluated with the Hamilton Rating Scale for Depression 21-items (HRSD-21) at baseline and after 6 months. A reduction ≥50 and <10 % in HDRS-21 score was considered as response or nonresponse to therapy, respectively, and the values of reduction between 10 and 49 % as poor responders. After 6 months of SSRI treatment, 176 patients responded, 54 patients did not respond and 99 patients showed a poor response. Ordinal logistic models showed a significant association between mutation of SNP rs1207568 and responders and, similarly, for each unitary risk allele increase overlapping results were found. Conversely, a significantly higher frequency of the minor genotype of SNP rs9536314 was found in nonresponders. Considering the pre-post differences of HRSD-21 scores as a continue variable, we confirmed a significant improvement of depressive symptoms after treatment in patients carrying at least one minor allele at rs1207568 and a worse response in patients homozygous for the minor allele at rs9536314. Our results were the first that suggested a possible role of KL in the complex pathway of SSRI response in late-life MDD.

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Section: Introductionmentioning

confidence: 99%

Klotho Gene and Selective Serotonin Reuptake Inhibitors: Response to Treatment in Late-Life Major Depressive Disorder

et al. 2016

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“…Although rates of major depression are lower than in young populations, depressive symptoms can be psychosocially debilitating to older adults, and are associated with increased morbidity and health care utilization. 42 The presence of depression may adversely impact postoperative recovery, and has been associated with:…”

Section: Depressionmentioning

confidence: 99%

Operative Risk Stratification in the Older Adult

Scandrett

Zuckerbraun

Peitzman

2015

Surgical Clinics of North America

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“…Diese äußern sich z. B. in einem unspezifischen Verlust körperlicher und psychischer Dynamik ("allgemeiner Abbau") ebenso wie in einer atypischen psychopathologischen Symptomatik, wie etwa demenzähnlichen Bildern oder durch Dysphorie und Somatisierungstendenzen geprägten Zuständen [7,8]. Besondere Beachtung verdienen wahnhaft depressive Syndrome, die typischerweise mit Symptomen wie Krankheits-, Verarmungs-oder Schuldwahn einhergehen und aufgrund ihrer Schwere und deutlich erhöhten Suizidgefährdung nicht übersehen werden dürfen.…”

Section: Depression Im Alterunclassified

Depression im Alter

Hewer

Kopf

2013

Z Gerontol Geriat

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Depression in Later Life: An Overview with Treatment Recommendations

Cited by 35 publications

References 116 publications

Klotho Gene and Selective Serotonin Reuptake Inhibitors: Response to Treatment in Late-Life Major Depressive Disorder

Klotho Gene and Selective Serotonin Reuptake Inhibitors: Response to Treatment in Late-Life Major Depressive Disorder

Operative Risk Stratification in the Older Adult

Depression im Alter

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