Depression in Older Adults With Schizophrenia Spectrum Disorders: Prevalence and Associated Factors

Diwan, Shilpa; Cohen, Carl I.; Bankole, Azziza; Vahia, Ipsit V.; Kehn, Michelle; Ramírez, Paul

doi:10.1097/jgp.0b013e31815ae34b

Cited by 60 publications

(44 citation statements)

References 27 publications

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“…We noted that the effect of citalopram on negative symptoms was partly mediated by improvements in symptoms of depression, even though depression and negative symptoms have been demonstrated as distinct clinical dimensions of schizophrenia. [26] This finding is consistent with observations of a degree of overlap between negative and depressive symptom domains,[14] and is encouraging in suggesting that improvement in both domains may be seen with citalopram treatment. Since negative symptoms have been associated with worse functioning[27] and quality of life,[28] improving this important dimension of schizophrenia with anti-depressants may produce a cascading chain of benefits resulting in improved functioning and quality of life.…”

Section: Discussionsupporting

confidence: 88%

Adding antidepressants to antipsychotics for treatment of subsyndromal depressive symptoms in schizophrenia: Impact on positive and negative symptoms

Vahia

Lanouette

Golshan

et al. 2013

Indian J Psychiatry

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Objectives:It remains unclear how augmenting anti-psychotic medications with anti-depressants impacts primary positive and negative symptoms of schizophrenia. In this study, we used data collected from a randomized trial comparing citalopram to placebo for management of subsyndromal depression (SSD) in schizophrenia and schizoaffective disorder, to assess the effects of antidepressant augmentation on positive and negative symptoms.Materials and Methods:Participants in this study conducted at the University of California, San Diego and the University of Cincinnati, were persons with schizophrenia or schizoaffective disorder aged 40 or older and who met study criteria for SSD. Patients were randomly assigned to flexible-dose treatment with citalopram or placebo augmentation of their current anti-psychotic medication. Analysis of covariance was used to compare changes in positive and negative syndrome scale (PANSS) scores between treatment groups. We also assessed mediating effects of improvement in depression and moderating effects of multiple factors on positive and negative symptoms.Results:There was significant improvement in PANSS negative symptoms scores in the citalopram group, which was partially mediated by improvement in depressive symptoms. There was no effect on PANSS positive scores.Conclusions:In patients with schizophrenia/schizoaffective disorder, treating depressive symptoms with citalopram appears to carry the added benefit of improving negative symptoms.

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Section: Discussionsupporting

confidence: 88%

Adding antidepressants to antipsychotics for treatment of subsyndromal depressive symptoms in schizophrenia: Impact on positive and negative symptoms

Vahia

Lanouette

Golshan

et al. 2013

Indian J Psychiatry

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“…La prévalence des patients dépressifs chez le sujet schizophrène âgé rejoint celle des sujets plus jeunes [3,4,12]. On retrouve une association entre symptômes dépressifs et positifs [3,4,5,12].…”

Section: Comparaison Avec Les Sujets D'âge Moyen Souffrant De Schizopunclassified

“…On retrouve une association entre symptômes dépressifs et positifs [3,4,5,12]. Ces résultats sont cohérents avec la littérature.…”

Section: Comparaison Avec Les Sujets D'âge Moyen Souffrant De Schizopunclassified

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Schizophrénie, vieillissement et dépression

Ortega¹,

Bazile²,

Pontonnier³

et al. 2009

Annales Médico-psychologiques, revue psychiatrique

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A c c e p t e d M a n u s c r i p t The authors thus give a progress report on the question of depression in schizophrenic old patients. The six descriptive studies studied concerning the depressive symptoms at the schizophrenic old patient show that the frequency of the depressive disorders seems more important in this group of patient than in the general population of the same age. The depressive symptoms seem to be more often associated with the positive symptoms than with the negative symptoms. It is not found of association in the studies between depressive symptoms and antipsychotic dose, negative and neurologic symptoms, and deterioration of neurocognitive functioning. We find in this category of patients some of depression's predictive variables of the old general population. The coming out of depressive disorders seems to be associated with severity of schizophrenia's disease and with bad everyday functioning.

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“…La prévalence de la dépression dans la population âgée avec une schizophrénie est élevée (approximativement 1,5 à 3 fois le taux dans la population générale de même âge) [8], [5,8,10,14,17].…”

Section: Qualité De Vie Et Symptômes Psychiatriquesunclassified

Qualité de vie, schizophrénie et avancée en âge

Roblin¹,

Vaille-Perret²,

Tourtauchaux³

et al. 2009

Annales Médico-psychologiques, revue psychiatrique

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RésuméAu-delà de 65 ans, la prévalence de la schizophrénie est estimée entre 0,1 % et 0,5 %.La majorité des sujets âgés avec une schizophrénie ont développé la maladie avant l'âge de AbstractAfter 65 years old, the prevalence of schizophrenia is included into 0.1 % to 0.5 %.Most older people with schizophrenia will have developed the illness before the age of 45 and 85 % of them live in the community. Although about one in seven persons with schizophrenia is aged 65 and older and the number of elderly with schizophrenia will increase in the next years, only 1% of literature on schizophrenia is dedicated to questions related to aging.Schizophrenia, a real mental disability, has an important repercussion on global functioning and particularly on quality of life (QOL). QOL of aging persons with schizophrenia is determined by many factors and doesn't only limit to symptoms presented by the patient.

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Depression in Older Adults With Schizophrenia Spectrum Disorders: Prevalence and Associated Factors

Cited by 60 publications

References 27 publications

Adding antidepressants to antipsychotics for treatment of subsyndromal depressive symptoms in schizophrenia: Impact on positive and negative symptoms

Adding antidepressants to antipsychotics for treatment of subsyndromal depressive symptoms in schizophrenia: Impact on positive and negative symptoms

Schizophrénie, vieillissement et dépression

Qualité de vie, schizophrénie et avancée en âge

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