Depression in Parkinson's disease

Aarsland, Dag; Cummings, Jeffrey L.

doi:10.1034/j.1600-0447.2002.2e009.x

Cited by 12 publications

(4 citation statements)

References 14 publications

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“…The PDD, but not the DLB, patients showed a further significant increase in depression scores when compared with the PIGD‐PD cases (Tables 1 and 4), but the mean scores were again modest. Multivariate analysis indicated that, in accordance with previous observations,49 cognitive impairment (as assessed by MMSE score) may influence depression rating. Our data are, however, generally consistent with previous observations, that affective disturbance is more common in PD patients with greater posture and balance problems 14, 29…”

Section: Discussionsupporting

confidence: 88%

Extrapyramidal features in Parkinson's disease with and without dementia and dementia with Lewy bodies: A cross‐sectional comparative study

et al. 2003

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Risk factors predicting an increased risk of dementia in Parkinson's disease (PD) are not fully established. The dementia associated with PD (PDD) closely resembles dementia with Lewy bodies (DLB). Based upon a high frequency of non-dopaminergic mediated clinical features in DLB, we predicted that a motor subtype comprising postural instability and balance problems would be more common in PDD. We examined extrapyramidal, cognitive, and affective features in 38 PD, 43 PDD, and 26 DLB patients in a cross-sectional study design. Motor subtype was subdivided into postural-instability gait difficulty (PIGD) or tremor (TD) dominant. The PIGD-subtype was more common in PDD (88% of cases) and DLB (69% of cases) groups compared with the PD group (38% of cases), in which TD and PIGD sub-types were more equally represented (P < 0.001). Although the mean depression scores overall were modest, PDD patients scored significantly higher than PD, but not DLB patients (Cornell; P = 0.006, and Geriatric Depression scale, GDS-15; P = 0.001), while within the PD group, those patients with a PIGD subtype had greater depression scores than the TD subtype (GDS-15; P < 0.05). We conclude that non-dopaminergic motor features are frequent in PDD. Neurodegeneration within the cholinergic system is likely to mediate many of these motor problems, as well as playing a significant role in determining the neuropsychiatric symptomatology of both PDD and DLB.

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Section: Discussionsupporting

confidence: 88%

Extrapyramidal features in Parkinson's disease with and without dementia and dementia with Lewy bodies: A cross‐sectional comparative study

et al. 2003

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“…The recent literature shows that the impact of non-motor symptoms on daily function in the patients with PD is notable [ 1 – 3 ]. Depression is one of the most prevalent neuropsychiatric symptoms in patients with PD [ 4 , 5 ]. Among non-motor symptoms, depression is one that has a great impact on the quality of life of patients with PD and their caregivers [ 3 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Test-retest reliability and minimal detectable change of the Beck Depression Inventory and the Taiwan Geriatric Depression Scale in patients with Parkinson's disease

Huang

Hsieh

et al. 2017

PLoS ONE

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BackgroundThe Beck Depression Inventory II (BDI-II) and the Taiwan Geriatric Depression Scale (TGDS) are self-report scales used for assessing depression in patients with Parkinson’s disease (PD) and geriatric people. The minimal detectable change (MDC) represents the least amount of change that indicates real difference (i.e., beyond random measurement error) for a single subject. Our aim was to investigate the test-retest reliability and MDC of the BDI-II and the TGDS in people with PD.MethodsSeventy patients were recruited from special clinics for movement disorders at a medical center. The patients’ mean age was 67.7 years, and 63.0% of the patients were male. All patients were assessed with the BDI-II and the TGDS twice, 2 weeks apart. We used the intraclass correlation coefficient (ICC) to determine the reliability between test and retest. We calculated the MDC based on standard error of measurement. The MDC% was calculated (i.e., by dividing the MDC by the possible maximal score of the measure).ResultsThe test-retest reliabilities of the BDI-II/TGDS were high (ICC = 0.86/0.89). The MDCs (MDC%s) of the BDI-II and TGDS were 8.7 (13.8%) and 5.4 points (18.0%), respectively. Both measures had acceptable to nearly excellent random measurement errors.ConclusionsThe test-retest reliabilities of the BDI-II and the TGDS are high. The MDCs of both measures are acceptable to nearly excellent in people with PD. These findings imply that the BDI-II and the TGDS are suitable for use in a research context and in clinical settings to detect real change in a single subject.

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“…Theoretically L-dopa may promote depression (especially in individuals with history of depression) while on the other hand L-dopa acts as an antidepressant by improving motor abilities [26,30]. The other predictive factors for depression are akinesia, coexisting cognitive dysfunction and the parkinsonian symptoms predominant on the right side of the body [1].…”

Section: Introductionmentioning

confidence: 99%

Factors associated with depression in Parkinson’s disease: a cross-sectional study in a Polish population

et al. 2006

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Depression in Parkinson's disease

Cited by 12 publications

References 14 publications

Extrapyramidal features in Parkinson's disease with and without dementia and dementia with Lewy bodies: A cross‐sectional comparative study

Extrapyramidal features in Parkinson's disease with and without dementia and dementia with Lewy bodies: A cross‐sectional comparative study

Test-retest reliability and minimal detectable change of the Beck Depression Inventory and the Taiwan Geriatric Depression Scale in patients with Parkinson's disease

Factors associated with depression in Parkinson’s disease: a cross-sectional study in a Polish population

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