BackgroundNo available measure of anxiety and depression exists for illiterate non-English speaking Igbo Nigerians who have one of the greatest global burden of back pain. This study translated, culturally adapted and psychometrically tested the hospital anxiety and depression scale (HADS) in rural and urban Nigerian populations with chronic low back pain (CLBP). MethodsHADS was translated forwards and backwards by clinical and non-clinical translators; appraised by an expert review committee; and pre-tested among twelve rural Nigerian dwellers with CLBP. Cronbach’s alpha, intraclass correlation coefficient, Bland–Altman plots and minimal detectable change were investigated amongst 50 rural and urban Nigerian dwellers with CLBP. Construct validity was investigated using Roland Morris Disability Questionnaire, World Health Organisation Disability Assessment Schedule, Fear Avoidance Beliefs Questionnaire and eleven-point box scale of pain intensity; and exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) using randomly selected 200 adults with CLBP in rural Nigeria. ResultsThere was difficulty achieving cross-cultural equivalence with western idioms. Internal consistency, intra class correlation coefficients, standard error of measurements, and minimal detectable change were good. Igbo-HADS correlated at least moderately with generic self-reported disability, self-reported back pain-specific disability, fear avoidance beliefs and pain intensity. The EFA produced a two-factor structure and cross-loading of items. The CFA showed no good fit indices for the Igbo-HADS EFA structure, and the original two-factor and one-factor structures identified in the literature. ConclusionIgbo-HADS measures emotional distress. However, the suitability of the HADS for assessing anxiety and depression, or emotional distress in this particular population is doubtful.